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Search Results - zzcardiology
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A Novel Immunomodulatory Strategy for Treating Heart Failure in Aging Populations
Advantages Novel Mechanism of Action: Targets the Th17/IL17A signaling axis Validated Target: IL17A is already clinically validated in other inflammatory diseases (e.g., psoriasis, psoriatic arthritis), with FDA-approved therapies like secukinumab Strong Preclinical POC: transcriptomic, histological, and functional cardiac assessments showing reversal...
Published: 8/25/2025
|
Inventor(s):
Wanling Xuan
,
Srinivas Tipparaju
Keywords(s):
Cardiological Diseases Treatment
,
Cardiovascular Diseases
,
Drug Discovery
Category(s):
zzCardiology
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Therapeutics
Novel Nampt Activators and Synthesis Method to Treat Inflammation and Wound Healing
Advantages: Therapeutic Applications: 2-Aminothiazole scaffold is known for its wide range of therapeutic properties, including antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. Compounds showed increased Nampt enzymatic activity Efficient Synthesis: efficient one-pot synthetic route using resorcinarene cavitand glycoconjugates...
Published: 4/22/2025
|
Inventor(s):
Kirpal Bisht
,
Srinivas Tipparaju
Keywords(s):
Category(s):
zzCardiology
,
Technology Classifications > Medical > Pharmaceuticals