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Microneedle array coating technology for enhanced stability and targeted delivery of mRNA and biologics

A microneedle-based system uses cryogenically pre-cooled needles coated via thin-film freeze-coating to preserve mRNA stability, enabling efficient, multi-therapeutic intradermal delivery of temperature-sensitive drugs. Background The field of advanced drug delivery systems has grown substantially as the biomedical industry grapples with the complexities...

Published: 1/27/2026 | Inventor(s): Zhengrong Cui, Michael Sandoval, Robert Williams, Drew Weissman, Qin Li

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug discovery

Contact Lens Design

This technology is a novel specialty soft contact lens that helps align the eyes in children with intermittent exotropia type strabismus, while preventing any adverse myopia progression, offering both vision correction and cosmetic improvement without worsening nearsightedness. Background: Strabismus, particularly exotropia, is a condition characterized...

Published: 1/27/2026 | Inventor(s): Zi Rui Li

Keywords(s): Technologies

Category(s): Campus > SUNY College of Optometry, Technology Classifications > Healthcare

Lipid nanoparticles for targeted delivery of therapeutic agents in acute lung injury

This technology uses lung-targeting lipid nanoparticles to deliver a combination of anti-inflammatory and immune-modulating drugs directly to the lungs, offering a more effective and targeted treatment for acute lung injury and acute respiratory distress syndrome. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...

Published: 1/15/2026 | Inventor(s): Yamin Li, Yuqin Men, Robert Cooney, Qinghe Meng

Keywords(s): acute lung injury, anti-inflammatory therapeutic, drug delivery, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery

Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells

This technology uses specially designed sulfonium lipid nanoparticles to deliver mRNA directly to lung cells through the nose, offering a non-invasive, more effective and targeted treatment for pulmonary diseases like asthma and cystic fibrosis. Background: The field of pulmonary medicine faces significant challenges in the treatment of diseases...

Published: 1/9/2026 | Inventor(s): Yamin Li, Yuqin Men

Keywords(s): active pharmaceutical ingredient, chemicals, drug delivery, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery

Resonant Excitation of Compression Mechanical Modes in a Mechanical Resonator with an Optical Gradient Force

1. Technology Overview The invention introduces ultracoherent GHz diamond spin-mechanical Lamb wave resonators (LWRs) protected by a phononic band gap. These resonators enable coherent interactions between single phonons and spins, providing a robust platform for quantum spin-mechanics. The technology leverages all-optical excitation and detection...

Published: 1/8/2026 | Inventor(s): Hailin Wang, Jens Noeckel, Xinzhu Li

Keywords(s):

Category(s): Communications, Nanoscience & Microtechnologies, Physical Science

Transgenic Mouse Model for Marfan Syndrome Research

Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...

Published: 12/23/2025 | Inventor(s): Li Li, Shichao Wu, Jiawei Zhao

Keywords(s):

Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic

Portable Thermal Nitric Oxide Generation Technology

Novel chemical composition that enables pure NO gas release upon heat. Technology Summary This technology enables safe, efficient, and portable generation of medical-grade nitric oxide (NO) by thermally activating a bench-stable solid-state NO-releasing molecule embedded in a porous polymer matrix. FDA approved Inhaled nitric...

Published: 12/16/2025 | Inventor(s): James Bour, Shuxiao Li

Keywords(s):

Category(s): Technology Category, Technology Category > Medical Devices, Technology Category > Drug Delivery, Technology Category > Driving Lifelong Health, Technology Category > Life Science

Low-Cost High-Performance 3D LiDAR Imaging System

Description: This innovative 3D imaging system uses time-of-flight measurement of photons with a conventional global shutter CMOS camera to generate accurate distance data converted into brightness levels. It includes a laser source, camera, delay generator, master trigger, and electronic control unit (ECU) which together capture and average multiple...

Published: 12/16/2025 | Inventor(s): Wen Li, Suk Kyoung Lee, Blessed Oguh, Sulaiman Abubakar

Keywords(s):

Category(s): Technology Category > Automotive & Transportation, Technology Category > Physical Sciences, Technology Category > Image Analysis (Cameras & Software), Technology Category > Revolutionizing Mobility

Monitoring Structural Health Using Diffractive Optical Processors (Case No. 2025-201)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel structural health monitoring system that is highly accurate and cost effective, addressing limitations in current infrastructure and civil health monitoring and a rise in public safety concerns. Background: The need for structural health monitoring...

Published: 12/5/2025 | Inventor(s): Aydogan Ozcan, Ertugrul Taciroglu, Yuntian Wang, Yuhang Li

Keywords(s): 3D structures, Adaptive Optics, AI-generated images and content, all-optical diffractive computing, all-optical transformation, analog computing, analog optical computing, Analogue Electronics, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, artificial-intelligent materials, civil engineering, civil infrastructure, civil monitoring, computational imaging, computational imaging task, Construction, deep diffractive network, Diffraction, diffractive design, diffractive image reconstruction, diffractive network, diffractive processor, diffractive surface, digital image reconstruction, electromagnetic spectrum, Electro-Optics, Image Analysis, Image Processing, Image Resolution, image restoration, image signal processing, Imaging, Infrastructure, Lens (Optics), linear optics, Nanostructure, optical processor, optically-guided structural monitoring, Optics, passive light-matter interactions, security imaging, Signal Reconstruction, Structural health monitoring, structural health monitoring (SHM), structure monitoring, Structures

Category(s): Electrical, Electrical > Signal Processing, Electrical > Imaging, Materials, Materials > Construction Materials, Electrical > Visual Computing, Electrical > Computing Hardware, Electrical > Instrumentation, Energy & Environment, Energy & Environment > Energy Efficiency, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Software & Algorithms > Programs

Sulfonyl-purine probes for covalent targeting of lysine and tyrosine in drug discovery

Background A significant portion of the human proteome remains inaccessible to traditional drug discovery approaches, particularly proteins lacking reactive cysteines or well-defined binding pockets. These so-called “undruggable” targets present major challenges for small molecule therapeutics, limiting the development of treatments for...

Published: 1/13/2026 | Inventor(s): Ku-Lung Hsu, Zhihong Li

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Research tools > Reagent

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