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Machine-learning guided fast optimization of materials synthesis with high quality
A fast-convergence machine learning approach for materials synthesis optimization, with minimal training data Background: Materials synthesis is a complicated and lengthy process requiring a high degree of precision. At the same time, there is a constant need to develop new materials, adapt existing ones, and improve the quality of materials synthesis....
Published: 7/11/2025   |   Inventor(s): Swastik Kar, Xiaoning Jin, Guoyan Li, Yujia Wang
Keywords(s): 2D materials, Artificial intelligence, Experimental Design, Optimization
Category(s): Technology Classifications > 3. Computer Science > AI, Technology Classifications > 2. Physical Science > Manufacturing
Monitoring Structural Health Using Diffractive Optical Processors (Case No. 2025-201)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel structural health monitoring system that is highly accurate and cost effective, addressing limitations in current infrastructure and civil health monitoring and a rise in public safety concerns. Background: The need for structural health monitoring...
Published: 7/25/2025   |   Inventor(s): Aydogan Ozcan, Ertugrul Taciroglu, Yuntian Wang, Yuhang Li
Keywords(s): 3D structures, Adaptive Optics, AI-generated images and content, all-optical diffractive computing, all-optical transformation, analog computing, analog optical computing, Analogue Electronics, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence algorithms, artificial intelligence augmentation, artificial intelligence/machine learning models, artificial-intelligent materials, civil engineering, civil infrastructure, civil monitoring, computational imaging, computational imaging task, Construction, deep diffractive network, Diffraction, diffractive design, diffractive image reconstruction, diffractive network, diffractive processor, diffractive surface, digital image reconstruction, electromagnetic spectrum, Electro-Optics, Image Analysis, Image Processing, Image Resolution, image restoration, image signal processing, Imaging, Infrastructure, Lens (Optics), linear optics, Nanostructure, optical processor, optically-guided structural monitoring, Optics, passive light-matter interactions, security imaging, Signal Reconstruction, Structural health monitoring, structural health monitoring (SHM), structure monitoring, Structures
Category(s): Electrical, Electrical > Signal Processing, Electrical > Imaging, Materials, Materials > Construction Materials, Electrical > Visual Computing, Electrical > Computing Hardware, Electrical > Instrumentation, Energy & Environment, Energy & Environment > Energy Efficiency, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Software & Algorithms > Programs
Ease-of-manufacture Highly Transparent Thin Polyvinyl Alcohol Aerogel
Energy-efficient and cost-effective method for manufacturing transparent and robust PVA aerogels for green energy applications Background: Aerogels, particularly silica-based variants, have been widely used for their exceptional thermal insulation and transparency. However, their fragility has posed significant challenges for broader applications,...
Published: 6/13/2025   |   Inventor(s): Yi Zheng, Xiaoli Li
Keywords(s):  
Category(s): Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 2. Physical Science > Environmental/Clean tech
CBLs as a biomarker of and target to treat systemic lupus erythematosus (SLE)
SLE DIAGNOSTIC TOOL CBL protein levels used as a molecular diagnostic marker to diagnose and assess severity of Systemic Lupus Erythematosus (SLE) Systemic Lupus Erythematosus patient (photo: NCRD) UNMET NEED Systemic Lupus Erythematosus (SLE) is an autoimmune disease, especially prevalent in women, and without curative treatment. In addition,...
Published: 7/7/2025   |   Inventor(s): Xin Li, Zhe-Xiong Lian, Hua Gu
Keywords(s): Innovation
Category(s): Applications > Soins et santé > Diagnostic, English Applications > Health and care > Diagnostic-ENG, Secteurs > Sciences de la vie, Sectors > Life sciences, Objectifs de Développement Durable > ODD 03 : Bonne santé et bien-être, Sustainable Development Goals > Goal 03: Good Health and Well-Being
Hemodynamics Driven Magnetoelastic Vascular Graft (Case No. 2025-124)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel magnetoelastic vascular graft to provide real-time, wireless, and continuous stenosis monitoring. TITLE: Hemodynamics Driven Magnetoelastic Vascular Graft Background: Vascular grafts are commonly used to restore blood flow in patients with blocked or damaged blood...
Published: 7/3/2025   |   Inventor(s): Jun Chen, Song Li, Guorui Chen
Keywords(s): cardiovascular monitoring, Diagnostic Platform Technologies (E.G. Microfluidics), hemodynamic monitoring, Hemodynamics, magnetoelastic sensor, Medical diagnostics, Vascular therapy
Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Medical Devices > Monitoring And Recording Systems, Therapeutics > Autoimmune, Therapeutics > Immunology And Immunotherapy, Therapeutics > Transplant, Therapeutics > Hematology, Therapeutics > Cardiovascular
Diffractive Waveguides (Case No. 2025-012)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed innovative high performance diffractive waveguides adaptable to any task and that achieve desired specifications for applications spanning telecommunications, sensing, spectroscopy, and integrated photonics circuits. Background: Waveguides are crucial...
Published: 6/25/2025   |   Inventor(s): Aydogan Ozcan, Yuhang Li, Yuntian Wang
Keywords(s): Adaptive Optics, deep diffractive network, Deep Learning, Deep learning-based sensing, Diffraction, diffractive network, Dispersion (Optics), optimization, Phase (Waves), real-time sensing/monitoring/tracking, Waveguide, Waveguide (Electromagnetism), Waveguide Light, Waveguide Waveguide (Electromagnetism), Wavelength
Category(s): Electrical > Sensors, Electrical > Signal Processing, Electrical > Visual Computing > Diffractive Computing, Electrical > Imaging
PTH1R PROTAC
Project ID: TECH-2025-20 Background Every 16 mins a man will die of Prostate cancer. Bone metastasis is the predominant cause of morbidity and mortality in prostate cancer, with > 80 % of lethal cases exhibiting skeletal involvement. Parathyroid hormone-related protein (PTHrP), secreted by tumor cells, binds and activates PTH1R on osteoblasts and...
Published: 6/25/2025   |   Inventor(s): Xiaohong Li, Shang Su, Tim (Qingbin) Cui, Jian-Ting Zhang
Keywords(s):  
Category(s): Oncology
Design of Wireless Interrogated MEMS Capacitive Intraocular Pressure Sensors
Advantages Detects intraocular pressure changes with sub-0.1 mmHg resolution for superior clinical precision. Battery-free wireless design enables safe, continuous monitoring through inductive telemetry technology. Biocompatible materials ensure long-term implantation with minimal risk and high patient safety. MEMS-based fabrication allows cost-effective,...
Published: 6/3/2025   |   Inventor(s): Ramesh Ayyala, Liguan Li, Jing Wang
Keywords(s): Ophthalmic Equipment, Ophthalmology
Category(s): Technology Classifications > Medical > Ophthalmology
First in class Small Molecule Agonists of the mammalian Relaxin family receptor 1 (RXFP1) and use in treatment of cancer, fibrotic, and vascular disorders (HHS Ref No. E-145-2024-0-US-02)
It is well documented in literature that activation of RXFP1 by relaxin induces: 1) up-regulation of the endothelin system which leads to vasodilation; 2) extracellular matrix remodeling through regulation of collagen deposition, cell invasiveness, proliferation, and overall tissue homeostasis; 3) a moderation of inflammation by reducing levels of inflammatory...
Published: 5/30/2025   |   Inventor(s): Juan Marugan, Mark Henderson, Kenneth Wilson, Wenwei Huang, Wenjuan Ye, Noel Southall, Jiankang Jiang, Khalida Shamim, Bing Li, Alexander Agoulnik, Abhijeet Kapoor, Joshua Hutcheson, Ana Cabrera, Irina Agoulnik
Keywords(s):  
Category(s): Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Pulmonology, TherapeuticArea > Dermatology, TherapeuticArea > Reproductive Health, TherapeuticArea > Geriatrics
Nanocage Sensors
The molecular nanocage concept can verify the purity and authenticity of agricultural products and could detect environmental contaminants Background: Increasing globalization and competition has created large economic incentives to commit food fraud by adding adulterants, fillers, or other inauthentic ingredients to agricultural products. Consequently,...
Published: 5/21/2025   |   Inventor(s): Jianing Li, Severin Schneebeli, Mona Sharafi
Keywords(s):  
Category(s): Technology Classifications > Agriculture, Technology Classifications > Biomedical
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