Search Results - vaccines%2fantimicrobials

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Rapid Tuberculosis and Mycobacteria Phenotypic Drug Susceptibility Testing
Mycobacterium tuberculosis (TB) remains a major global health threat, causing nearly 1.5 million deaths annually, making it the 13th leading cause of death. While TB is preventable and treatable, multidrug-resistant TB worsens the global health crisis, making diagnosis and treatment more complex. An even greater challenge is heteroresistance, where...
Published: 4/8/2025   |   Inventor(s): Shelley Haydel, Shaopeng Wang, Jiapei Jiang, Yannik Haller
Keywords(s):  
Category(s): Artificial Intelligence/Machine Learning, Vaccines/Antimicrobials, Life Science (All LS Techs), Imaging, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices
Rescue from Glycolysis and mRNA Based Vaccines
Glycolysis inhibition in cancer cells has long been recognized as a viable strategy to prevent cancer cell growth. Cancer cells are known to have a high glucose consumption rate as a metabolism adaptation mechanism called the Warburg effect. Activated immune cells also rely on glycolysis for their energy needs. For example, glycolysis is essential for...
Published: 2/19/2025   |   Inventor(s): Abhinav Acharya
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Life Science (All LS Techs), Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals, Vaccines/Antimicrobials, Cancer, Cancer Therapeutics, Biomaterials
Metabolically-fit Immunotherapies Portfolio
M23-139L – Inducing or Rescuing Glycolysis in Cancer Cells. Compositions that selectively block glycolysis in cancer cells while simultaneously enable glycolysis in non-cancer cells, such as macrophages, T cells, NK cells, etc. Vaccine formulations have been developed and tested on mice with positive results. Please see the published PCT (WO2024151709A1)...
Published: 2/13/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Biological Nanotechnology, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Vaccines/Antimicrobials
Formulations to Prevent Neurological Diseases and Disorders, including TBI
Traumatic brain injury (TBI) is a major source of death and long-term physical, cognitive and mental disability worldwide, with roughly 27 million new cases each year. In the U.S. alone, this results in almost 70,000 deaths, annually. Although TBIs can affect people of all ages, the risk of getting a TBI is greatest in adolescents, young adults and...
Published: 2/13/2025   |   Inventor(s): Abhinav Acharya, Sarah Stabenfeldt
Keywords(s):  
Category(s): Vaccines/Antimicrobials, Pharmaceuticals, Non-Cancer Therapeutics, Neurodegenerative Disease Technologies, Life Science (All LS Techs)
Drone Deployable Automated Pellet Dispensing System
Black-footed ferrets have become one of the most endangered animals in North America due to the emergence of the sylvatic plague, a flea-borne bacterial disease of wild rodents. To mitigate the loss of this species, a sylvatic plague vaccine (SPV) has been developed in combination with a peanut butter bait for oral administration to wildlife. Current...
Published: 2/13/2025   |   Inventor(s): Jnaneshwar Das, Devin Keating, Cole Brauer
Keywords(s):  
Category(s): Agriculture/Animal Health, Environmental, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Vaccines/Antimicrobials
Novel Vaccines and Therapeutics Against Melioidosis
Background Melioidosis, also commonly known as Whitmore’s disease, is an infection caused by the bacterium Burkholderia pseudomallei (B. pseudomallei) that currently has an estimated mortality rate of 54%. This bacteria lives in contaminated soil and surface water, and can be transmitted to humans or animals through direct contact. This bacterium...
Published: 2/13/2025   |   Inventor(s): Tung Hoang, Ian McMillan, Yun Heacock-Kang, Zhenxin (Amy) Sun, Jan Zarzycki-Siek, Michael Norris
Keywords(s):  
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Vaccines/Antimicrobials
Model for TCR Analysis and its Application to TCR-Epitope Binding Prediction and TCR Clustering
T cell receptors (TCRs) play an important role in the adaptive immune system. The ability to accurately predict or characterize binding interactions between TCRs and target antigens, partly because of the vast diversity of TCRs and epitopes, is challenging. While there has been progress in the development of computational models dedicated to this, the...
Published: 2/13/2025   |   Inventor(s): Heewook Lee, Pengfei Zhang, Michael Cai, Seojin Bang
Keywords(s):  
Category(s): Computing & Information Technology, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Vaccines/Antimicrobials
Increasing the Antigenic Insertion Sites on the Recombinant Immune Complex Platform
Recombinant protein subunit vaccines offer an improved safety profile compared to live attenuated or inactivated vaccines, making them a promising vaccine strategy. These vaccines can further enhance immunogenicity through fusion with IgG-based protein scaffolds, such as immune complex (RIC) platforms. RIC consists of an antibody and antigen complex...
Published: 2/13/2025   |   Inventor(s): Hugh Mason, Mary Pardhe, Andrew Diamos
Keywords(s):  
Category(s): Vectors/Constructs/Plasmids, Vaccines/Antimicrobials, Non-Cancer Therapeutics, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Protein/Pharma Production in Plants
Method for Production of Self-Replicating, Nucleic Acid-Loaded Virus-Like Particles in plants
Vaccines are an essential tool in preventing and controlling many diseases. Most approved vaccines are inactivated or live attenuated type, however, alternative platforms like mRNA and virus-like particles (VLPs) are being increasingly explored and approved because they generate potent immune responses with great safety profiles. VLPs are particularly...
Published: 2/13/2025   |   Inventor(s): Qiang Chen, Huafang Lai
Keywords(s):  
Category(s): Agriculture/Animal Health, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Vectors/Constructs/Plasmids, Protein/Pharma Production in Plants, Vaccines/Antimicrobials
Prediction Algorithm for MHC-bound Peptides & SARS-CoV-2 Peptides for Vaccines
T cell immunity is a fundamental component of the immune response to infections, cancer, and autoimmunity and is strongly impacted by polymorphisms in major histocompatibility complex (MHC) protein sequences. In particular, allelic MHC-I protein variants have been shown to influence patient outcomes to various viral infections, including SARS-CoV. While...
Published: 2/13/2025   |   Inventor(s): Karen Anderson, Abhishek Singharoy, Eric Wilson
Keywords(s):  
Category(s): Computing & Information Technology, Coronavirus, COVID-19, Life Science (All LS Techs), Pharmaceuticals, Vaccines/Antimicrobials, SARS-CoV-2, Proteomic Assays/Reagents/Tools, Intelligence & Security
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