Search Results - andrew+diamos

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Increasing the Antigenic Insertion Sites on the Recombinant Immune Complex Platform
Recombinant protein subunit vaccines offer an improved safety profile compared to live attenuated or inactivated vaccines, making them a promising vaccine strategy. These vaccines can further enhance immunogenicity through fusion with IgG-based protein scaffolds, such as immune complex (RIC) platforms. RIC consists of an antibody and antigen complex...
Published: 9/18/2023   |   Inventor(s): Hugh Mason, Mary Pardhe, Andrew Diamos
Keywords(s):  
Category(s): Vectors/Constructs/Plasmids, Vaccines/Antimicrobials, Non-Cancer Therapeutics, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Protein/Pharma Production in Plants
Novel Vectors which Spread from Cell-to-Cell in Plants
Plants are a promising platform for rapid production of biologics as they offer many advantages over traditional systems, including safety, speed, versatility and cost. Geminiviruses are a group of small plant viruses that have been studied and used extensively in such plant-based production systems. Because geminiviruses replicate in nuclei, their...
Published: 2/23/2023   |   Inventor(s): Hugh Mason, Andrew Diamos
Keywords(s):  
Category(s): Agriculture/Animal Health, Life Science (All LS Techs), Pharmaceuticals, Vectors/Constructs/Plasmids, Protein/Pharma Production in Plants
Modified Geminiviral Vectors to Reduce Cell Death & Enhance Expression
Plants are a promising platform for rapid production of biologics as they offer many advantages over traditional systems, including safety, speed, versatility and cost. And the demonstration of plant-made pharmaceuticals that have been glycoengineered to have authentic human N-glycans further underscores their promising potential. However, high accumulation...
Published: 2/23/2023   |   Inventor(s): Hugh Mason, Andrew Diamos
Keywords(s):  
Category(s): Agriculture/Animal Health, Pharmaceuticals, Protein/Pharma Production in Plants, Vectors/Constructs/Plasmids, Life Science (All LS Techs)
Vaccine for Preventing Necrotic Enteritis in Poultry
Necrotic enteritis (NE), caused by type A strains of the bacterium Clostridium perfringens, results in a global economic loss of over 2 billion dollars, annually, to the poultry industry. C. perfringens causes chronic sub-clinical intestinal mucosal damage, leading to a reduction in the ability of birds to benefit from nutrients in food and reduced...
Published: 2/23/2023   |   Inventor(s): Kenneth Roland, Hugh Mason, Andrew Diamos
Keywords(s):  
Category(s): Agriculture/Animal Health, Life Science (All LS Techs), Vaccines/Antimicrobials