Search Results - biological+nanotechnology

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SiMPLE: A Low-Cost, Scalable Method for High-Density DNA Origami Nanoarray Fabrication
Single-molecule techniques make it possible to digitally count even extremely rare biomarker molecules, providing greatly improved sensitivity for early disease detection. However, in standard setups, there is a necessary balance: if the concentration is too high, molecules overlap and become unreadable; if too low, there are not enough events for robust...
Published: 9/2/2025   |   Inventor(s): Prathamesh Chopade, Rizal Hariadi, Deeksha Satyabola, Aaron Sakai
Keywords(s):  
Category(s): Biological Nanotechnology, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Nucleic Acid/Peptide/Protein Therapies
Brain-Targeted Nanoparticles for Delivering Agents to the Brain
The blood brain barrier (BBB) is a highly selective semipermeable complex, and only about 2% of small molecules in the blood can penetrate it. Because of this, drug delivery to the brain is fairly ineffective. Research into receptors expressed on the BBB is promising, however, many receptors (glucose transporter 1, transferrin receptor, LDL-receptor...
Published: 8/27/2025   |   Inventor(s): Shu Wang, Zhaoyang Fan
Keywords(s):  
Category(s): Biological Nanotechnology, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs), Pharmaceuticals, Medical Imaging, Non-Cancer Therapeutics
Photoacoustic Nanosensor Probes for Imaging Neurotransmitter Dynamics
The ability to monitor spatiotemporal dynamics of neurotransmitter release is crucial for understanding the basis of brain function. The precise cognitive operations supported by the changes in cortical neuromodulatory activity have not been fully recognized, largely due to the limitations of current methods which have trade-offs between spatial, temporal,...
Published: 8/26/2025   |   Inventor(s): Heather Clark
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biological Nanotechnology, Life Science (All LS Techs), Imaging, Medical Devices, Medical Imaging
Nucleic Acid-Triggered Gated Pore Formation for Sensing and Signal Amplification
Cells have developed various means for transporting molecules across membranes as well as cellular compartments separated by membranes. Channels and pores can be formed with different protein assemblies to enable the regulated passage of molecules in and out of cells, which has led to them being exploited as molecular sensors for characterizing biomolecules...
Published: 6/23/2025   |   Inventor(s): Rizal Hariadi, Ranjan Sasmal
Keywords(s):  
Category(s): Biological Nanotechnology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices
DNA/RNA Origami Assembly Mediated by Functional Peptides
DNA and RNA nanostructures, e.g., DNA Origami, have great potential in biological applications, including extracellular matrix scaffolds and delivery vehicles for drugs and gene therapies. While folding DNA origami under physiological conditions is plausible, significant challenges and limitations remain. For example, isothermal annealing of DNA origami...
Published: 4/2/2025   |   Inventor(s): Di Liu, Bing Xu, Zhishang Li, Jiaqi Guo
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biological Nanotechnology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Nucleic Acid/Peptide/Protein Therapies
High-Throughput DNA Origami Nanoarrays
Traditional bulk diagnostic assays suffer from signal dilution and averaging, making it difficult to detect rare biomarkers and subtle molecular variations critical for early disease diagnosis. Microarrays address this limitation by enabling high-throughput, multiplexed analysis with improved specificity and sensitivity. Their structured array format...
Published: 3/27/2025   |   Inventor(s): Prathamesh Chopade, Rizal Hariadi
Keywords(s): DNA nanotechnology, Lithography, MicroArray, Nanofabrication, Nucleic Acid, Single Molecule
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Biological Nanotechnology, Diagnostic Assays/Devices, Life Science (All LS Techs)
Metabolically-fit Immunotherapies Portfolio
M23-139L – Inducing or Rescuing Glycolysis in Cancer Cells. Compositions that selectively block glycolysis in cancer cells while simultaneously enable glycolysis in non-cancer cells, such as macrophages, T cells, NK cells, etc. Vaccine formulations have been developed and tested on mice with positive results. Please see the published PCT (WO2024151709A1)...
Published: 2/13/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Biological Nanotechnology, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Vaccines/Antimicrobials