Search Results - abhinav+acharya

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Metabolic Reprogramming of Immune for Autoimmune Disorders Prevention/Reversal
Antigen-specific immune suppression or tolerance is a highly attractive strategy to prevent inflammation-induced tissue damage in rheumatoid arthritis (RA). Although there is insufficient knowledge about autoantigens in human RA, generating and expanding synovium-specific regulatory T cells, and suppressing synovium-specific follicular T-helper cells,...
Published: 2/19/2025   |   Inventor(s): Abhinav Acharya, Joslyn Mangal
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Non-Cancer Therapeutics, Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals
Neutrophil based CAR Therapies for Treatment
Chimeric antigen receptor (CAR)-T-cell-based immunotherapies have dramatically improved survival in cancer patients. Unfortunately, CAR-T cell therapies are associated with severe neurotoxicity, adverse events during clinical trials, and cytokine storm syndrome among others. Therefore, there is a great need to develop strategies that can keep the benefits...
Published: 2/19/2025   |   Inventor(s): Abhinav Acharya, Mamta Wankhede
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Pharmaceuticals, Nucleic Acid/Peptide/Protein Therapies
Metabolite Delivery for Modulating Metabolic Pathways of Cells
There is a great need to deliver metabolites intracellularly without modifying the metabolite itself and rescue immune cells against metabolic exhaustion. In cancer therapy, metabolic pathway inhibitors are used that starve both cancerous cells as well as non-cancerous cells. Therefore, the ability to target specific immune cells and deliver metabolites...
Published: 2/19/2025   |   Inventor(s): Abhinav Acharya
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer Therapeutics, Cancer, Life Science (All LS Techs), Pharmaceuticals, Nucleic Acid/Peptide/Protein Therapies
Central Carbon Metabolite Based Polymers for Immunotherapy
Inhibition of glycolysis or glutaminase pathway is an effective strategy to prevent cancer cell growth in vitro and in vivo. However, these pathways are also utilized by immune cells to mount responses against cancer cells, and therefore, utilizing, immunotherapies in the presence of such inhibitors is challenging. Thus, there is a need for technologies...
Published: 2/19/2025   |   Inventor(s): Abhinav Acharya, Sahil H Inamdar
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals
Central Carbon Metabolite Based Polymers for Tissue Regeneration
There is a rich history of successful drug delivery carriers made of biodegradable biomaterials. Biomaterials may degrade into metabolic by-products, which are capable of modulating the function of immune cells, including alpha-ketoglutarate (aKG), which induces alternative activation (immunosuppressive phenotype) in macrophages through metabolic reprogramming....
Published: 2/19/2025   |   Inventor(s): Abhinav Acharya, Kaushal Rege
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Non-Cancer Therapeutics, Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals, Cancer
Rescue from Glycolysis and mRNA Based Vaccines
Glycolysis inhibition in cancer cells has long been recognized as a viable strategy to prevent cancer cell growth. Cancer cells are known to have a high glucose consumption rate as a metabolism adaptation mechanism called the Warburg effect. Activated immune cells also rely on glycolysis for their energy needs. For example, glycolysis is essential for...
Published: 2/19/2025   |   Inventor(s): Abhinav Acharya
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Life Science (All LS Techs), Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals, Vaccines/Antimicrobials, Cancer, Cancer Therapeutics, Biomaterials
Formulations to Prevent Neurological Diseases and Disorders, including TBI
Traumatic brain injury (TBI) is a major source of death and long-term physical, cognitive and mental disability worldwide, with roughly 27 million new cases each year. In the U.S. alone, this results in almost 70,000 deaths, annually. Although TBIs can affect people of all ages, the risk of getting a TBI is greatest in adolescents, young adults and...
Published: 2/13/2025   |   Inventor(s): Abhinav Acharya, Sarah Stabenfeldt
Keywords(s):  
Category(s): Vaccines/Antimicrobials, Pharmaceuticals, Non-Cancer Therapeutics, Neurodegenerative Disease Technologies, Life Science (All LS Techs)
Covalent Organic Frameworks for Biomedical Applications
­ Nitric oxide (NO), and other gases, are utilized by the body to modulate immune responses in wound repair, tissue engineering, infection treatment and more. Much research has been spent developing materials that can deliver such gases in vivo, yet their labile nature makes delivery in a controlled fashion and with release of clinically relevant...
Published: 2/13/2025   |   Inventor(s): Abhinav Acharya, Arezoo Esrafili
Keywords(s):  
Category(s): Life Science (All LS Techs), Advanced Materials/Nanotechnology, Biomaterials, Pharmaceuticals
Cell-based Arrays for Screening Combination Drug Efficacy for Personalized Cancer Therapy
Arrays Require Just a Small Number of Rare Cells to Determine Best Combination of Drugs for Patient TreatmentThese cell-based arrays use a small sampling of cells to help isolate and identify a patient’s sensitivity to chemotherapeutic drugs in vitro, potentially personalizing treatment of cancer. The cancer stem cell hypothesis postulates that...
Published: 6/27/2021   |   Inventor(s): Edward Scott, Benjamin Keselowsky, Abhinav Acharya, Emina Huang, Matthew Carstens
Keywords(s):  
Category(s): Technology Classifications > Others > Others
Microarray for Efficient, Inexpensive Testing on Rare Patient-Derived Cells
Reduces Costs by Allowing Researchers to Test Multiple Agents SimultaneouslyThis cell-based microarray allows testing of a wide range of biological or pharmaceutical agents on small numbers of cells from rare populations. Patient-derived cells such as cancer cells, stem cells and precancerous cells are difficult and expensive to obtain. Inefficient...
Published: 6/27/2021   |   Inventor(s): Edward Scott, Benjamin Keselowsky, Abhinav Acharya, Emina Huang, Matthew Carstens
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Others