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Highly sensitive pressure sensor for diverse applications
A flexible, highly sensitive pressure sensor combines resistive and capacitive elements using a porous carbon nanotube–Eco flex material. It accurately detects a wide range of pressures, is easy to fabricate, and suits diverse applications like medical monitoring and environmental sensing. Background Pressure sensing technology plays a crucial...
Published: 1/8/2025   |   Inventor(s): Nanshu Lu, Kyoung-Ho Ha
Keywords(s):  
Category(s): Life sciences > Medical technology
Overcoming the Blood-Brain Barrier with Peptide-Functionalized Lipid Panoparticles
Peptide-functionalized lipid nanoparticles (pLNPs) for targeted messenger RNA (mRNA) delivery to the brain. Problem: Ionizable lipid nanoparticles (LNPs) have emerged as clinically advanced delivery vehicles for nucleic acids. However, as LNPs typically accumulate to the liver, tissue-specific delivery remains challenging, and systemic LNP delivery...
Published: 1/7/2025   |   Inventor(s): Michael Mitchell, Emily Laura Han
Keywords(s): Bioengineering, Drug Delivery, Neurodegenerative Diseases
Category(s): Technology Classifications > Therapeutics
Space Shuttle-Inspired Branched Lipid Nanoparticles As Potent mRNA Transporters
Lipid nanoparticles (LNPs) with reversibly attached branched lipid tails for the delivery of mRNA for gene therapy. Problem: Delivery of mRNA to target cells enables the expression of engineered proteins but mRNA is unstable and negatively charged, necessitating a delivery vehicle to ensure its entry into cells. LNPs can ferry mRNA across the cell...
Published: 11/26/2024   |   Inventor(s): Michael Mitchell, Xuexiang Han
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Nanotechnology, Obesity Metabolic Disease and Diabetes, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Solutions for endotracheal tube (ETT) management in ICU patients
Background/problem Patients in the Intensive Care Unit (ICU) often require prolonged mechanical ventilation via an Endotracheal Tube (ETT). The ETT must be correctly posi­tioned in the trachea and secured to prevent migration. However, factors such as patient movement, oral/nasal secretions, and adhesive deterioration often lead to ETT malpositioning....
Published: 12/16/2024   |   Inventor(s): Daniel Stromberg, Sung Hoon Jung, Chloe Ihonvbere, Rose Anconetani, Scott Davenport, Justine Le
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices
S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use
Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Neurology/Neurosurgery, Oncology, Therapeutics
LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases
Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Neurology/Neurosurgery, Therapeutics
Adjuvanted Lipid Nanoparticles (LNPs) Enhance Protective Immunity Imparted by SARS-CoV-2 mRNA Vaccine
A lipid nanoparticle formulation that elicits a strong innate immune response for improved vaccine protection Problem: Lipid nanoparticle (LNP)-formulated mRNA vaccines have revolutionized modern vaccinology through their ability to deliver mRNA vaccines with remarkable manufacturing flexibility. However, the modified (pseudouridylated) mRNA used in...
Published: 10/1/2024   |   Inventor(s): Michael Mitchell, Xuexiang Han, Drew Weissman, Mohamad Alameh
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Immunology, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Materials, Technology Classifications > Vaccines
Non-contact railway inspection
VALUE PROPOSITION Rail transportation is periodically marred by accidents, highlighting ongoing safety challenges. There is a need for effective rail inspection methods. Current techniques are hindered by limitations such as low detection accuracy and sensitivity, particularly at high speeds. This technology introduces a novel method for high-speed,...
Published: 9/27/2024   |   Inventor(s): Yiming Deng, Sunil Chakrapani, Ming Han, Zebadiah Miles
Keywords(s):  
Category(s): Analytical Instruments, Test and Measurement, Transportation
Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer
Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...
Published: 9/18/2024   |   Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji
Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics
Advanced PAI contrast agents for early cancer detection
This technology involves creating biodegradable nanoparticles (nanocapsules) that selectively target diseased cells, such as cancer cells, for imaging and treatment. These nanocapsules contain indocyanine green (ICG) dye aggre­gates, which are stable and offer high contrast when using near-infrared photo­acoustic imaging, enabling the detection...
Published: 8/2/2024   |   Inventor(s): Keith Johnston, Thomas Truskett, Ehsan Moaseri, Konstantin Sokolov, Sangheon Han, Behzad Changalvaie
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Therapeutics > Small molecule
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