Search Results - than+le

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Highly Accelerated and High-Resolution T1-Weighted MRI
This invention is for an accelerated, high-resolution T1-weighted magnetic resonance imaging (MRI) via modification of the three-dimensional magnetization-prepared rapid gradient echo (3D MP-RAGE) sequence. Through this modification, optimization is achieved by allowing for faster signal collection and shorter acquisition time with generation of optimal...
Published: 3/24/2025   |   Inventor(s): Silu Han, Nan-kuei Chen
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Radiology, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Healthcare Portfolios > Neurology
Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing (Case No. 2025-128)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a novel, high-sensitivity chemiluminescence vertical flow assay for rapid cardiac diagnostics, addressing current challenges in both modern and underserved healthcare settings. Background: Point-of-care (POC) testing is performed...
Published: 2/26/2025   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo, Merve Eryilmaz
Keywords(s):  
Category(s): Chemical, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Electrical > Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Therapeutics, Therapeutics > Cardiovascular
Intervertebral Disc Repair Using a 3D Porous Hybrid Protein Nanoscaffold
​ Histological analysis of rat intervertebral disc tissue prior to (left) and post injury (center) compared to 6 weeks post treatment (right). Invention Summary: Degeneration of fibrocartilaginous tissues, such as intervertebral discs (IVD), knee menisci, and other tendon-bone junctions, can lead to debilitating pain. IVD degeneration is the...
Published: 3/25/2025   |   Inventor(s): Ki-Bum Lee, Letao Yang, Inbo Han
Keywords(s):  
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Biomaterials
Defending Against Wi-Fi Spoofing Attacks Leveraging Physical-Layer Features
Advantages: Identifies Wi-Fi spoofing attacks by leveraging Doppler Effect and Symbol Timing Offset (STO) variations Protects against location manipulation, ensuring accurate navigation even in high-risk environments Improves navigation accuracy by differentiating legitimate and spoofed signals Cost-effective implementation with off-the-shelf...
Published: 1/22/2025   |   Inventor(s): Xiao Han, Yao Liu, Zhuo Lu
Keywords(s): Autonomous Vehicle, Cybersecurity , Telecommunication / Wireless Communication, Transportation
Category(s): Technology Classifications > Computer Science > C/S Cybersecurity, Technology Classifications > Computer Science > Algorithms
Highly sensitive pressure sensor for diverse applications
A flexible, highly sensitive pressure sensor combines resistive and capacitive elements using a porous carbon nanotube–Eco flex material. It accurately detects a wide range of pressures, is easy to fabricate, and suits diverse applications like medical monitoring and environmental sensing. Background Pressure sensing technology plays a crucial...
Published: 1/8/2025   |   Inventor(s): Nanshu Lu, Kyoung-Ho Ha
Keywords(s):  
Category(s): Life sciences > Medical technology
Overcoming the Blood-Brain Barrier with Peptide-Functionalized Lipid Panoparticles
Peptide-functionalized lipid nanoparticles (pLNPs) for targeted messenger RNA (mRNA) delivery to the brain. Problem: Ionizable lipid nanoparticles (LNPs) have emerged as clinically advanced delivery vehicles for nucleic acids. However, as LNPs typically accumulate to the liver, tissue-specific delivery remains challenging, and systemic LNP delivery...
Published: 1/7/2025   |   Inventor(s): Michael Mitchell, Emily Laura Han
Keywords(s): Bioengineering, Drug Delivery, Neurodegenerative Diseases
Category(s): Technology Classifications > Therapeutics
Space Shuttle-Inspired Branched Lipid Nanoparticles As Potent mRNA Transporters
Lipid nanoparticles (LNPs) with reversibly attached branched lipid tails for the delivery of mRNA for gene therapy. Problem: Delivery of mRNA to target cells enables the expression of engineered proteins but mRNA is unstable and negatively charged, necessitating a delivery vehicle to ensure its entry into cells. LNPs can ferry mRNA across the cell...
Published: 11/26/2024   |   Inventor(s): Michael Mitchell, Xuexiang Han
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Nanotechnology, Obesity Metabolic Disease and Diabetes, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Solutions for endotracheal tube (ETT) management in ICU patients
Background/problem Patients in the Intensive Care Unit (ICU) often require prolonged mechanical ventilation via an Endotracheal Tube (ETT). The ETT must be correctly posi­tioned in the trachea and secured to prevent migration. However, factors such as patient movement, oral/nasal secretions, and adhesive deterioration often lead to ETT malpositioning....
Published: 3/3/2025   |   Inventor(s): Daniel Stromberg, Sung Hoon Jung, Chloe Ihonvbere, Rose Anconetani, Scott Davenport, Justine Le
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices
S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use
Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Neurology/Neurosurgery, Oncology, Therapeutics
LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases
Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Neurology/Neurosurgery, Therapeutics
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