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Predictive Multi-Physics Smart Socket: Edge-AI Controlled Micro-Bladder Compression for Real-Time Prosthetic Comfort
Advantages Proactively prevents pain and tissue injury Reduces the need for frequent prosthetic refitting visits by 25-30% Enhances user mobility, stability, and overall quality of life through real-time, autonomous fit optimization Summary Nearly 30% of lower-limb amputees experience chronic pain or tissue injury due to poorly fitting prosthetic...
Published: 4/23/2026   |   Updated: 4/23/2026   |   Inventor(s): Trung Le, Evan Raketic, Carey Robinson
Keywords(s): Prosthetics
Category(s): Technology Classifications > Medical > Medical Prosthetics
Deep Learning-Enhanced Dual-Mode Multiplexed Optical Sensor for Point-Of-Care Diagnostics of Cardiovascular Diseases (Case No. 2026-178)
Summary: UCLA researchers in the Departments of Electrical and Computer Engineering and Bioengineering have developed a deep-learning-enhanced multiplexed optical biosensing platform that enables rapid, high sensitivity point-of-care quantification of multiple cardiac biomarkers for cardiovascular diagnostics. Background: Rapid and accessible cardiac...
Published: 3/24/2026   |   Updated: 3/24/2026   |   Inventor(s): Aydogan Ozcan, Dino Di Carlo, Gyeo-Re Han, Artem Goncharov, Merve Eryilmaz
Keywords(s): Biomarker, biomarkers, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular monitoring, cardiovascular therapeutic solution, Deep Learning, Deep learning-based sensing, deep neural networks (DNN), neural network, neural networks, Optics, Point Of Care, point-of-care, point-of-care testing
Category(s): Electrical, Optics & Photonics, Diagnostic Markers, Medical Devices > Cardiac, Medical Devices
OASIS-Net: An Obstetric Adversarial Semi-supervised Image Segmentation Network for Cervical and Fetal Head Ultrasound Imaging
Advantages Achieves over 96% Dice accuracy for cervical and fetal head segmentation with limited labeled data Enables near real-time performance (~19 FPS on GPU) suitable for clinical workflow integration Reduces dependence on large, annotated datasets through semi-supervised learning Improves boundary precision, lowering measurement errors in...
Published: 3/13/2026   |   Updated: 3/13/2026   |   Inventor(s): Tien Truong, Phat Huynh, Dang Nguyen, Minh Le, Thanh-Huy Nguyen, Nguyen Khanh Le
Keywords(s): Medical Imaging, Women’s Health
Category(s): Technology Classifications > Data/AI > D/AI Imaging, Technology Classifications > Medical > Medical Imaging, Technology Classifications > Medical > Womens Health
Fully Wearable Band for Long-Term Peripheral Ultrasound Neuromodulation in Pain Management
Wearable ultrasound neuromodulation device for peripheral nerve pain relief A wearable ultrasound armband uses a focused piezoelectric transducer and acoustic hydrogel to deliver low-intensity ultrasound pulses to peripheral nerves, noninvasively reducing chronic and neuropathic pain for several hours. Background Peripheral nerve stimulation has...
Published: 3/11/2026   |   Updated: 3/11/2026   |   Inventor(s): Huiliang Wang, William Barrera, Jinmo Jeong, Thomas Wynn, Xiang Qian, QiLiang Chen, Yaoyao Jia, Yiming Han
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices
Rapid Synthesis of Amidine-Incorporated Degradable Lipids for Non-Liver mRNA delivery
One-pot combinatorial chemistry for fast and facile synthesis of amidine-incorporated degradable cationic lipids for lipid nanoparticle formulation and non-liver nucleic acid delivery. Problem: Messenger RNA (mRNA)-based therapeutics and vaccines have broad applications for a variety of diseases but require safe and efficient delivery mechanisms. Lipid...
Published: 2/10/2026   |   Updated: 2/10/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Junchao Xu
Keywords(s): Bioengineering, Drug Delivery, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms
Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems. Problem: CRISPR therapies can permanently correct disease-causing genes, but today's CRISPR delivery systems are either too risky or not potent enough. Viral vectors raise red flags...
Published: 1/14/2026   |   Updated: 1/14/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Biomaterial-mediated Extracellular Vesicle Delivery CNS Regeneration
​ Reduction in cortical lesion volume post-TBI (a) and post-treatment (b); remyelination as shown by luxol fast blue-staining post-TBI (c) and post-treatment (d); and enhanced expression of occludin post treatment (f) as compared to post-TBI (e). Invention Summary: More than 3 billion people worldwide are affected by central nervous system...
Published: 4/15/2026   |   Updated: 10/3/2025   |   Inventor(s): Joshua Stein, Ki-Bum Lee, Inbo Han
Keywords(s): Bioengineering scaffolds, Biomaterials, Drug Delivery, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering
Nanocomposite Scintillators (Case No. 2024-203)
Summary UCLA researchers have developed a nanocomposite scintillator material combining high-atomic-number (high-Z) nanoparticles embedded in a plastic (polymer) matrix, with tunable nanoparticle loading, that delivers higher light output and ultrafast emission (nanosecond-scale) while maintaining low background radiation and environmental stability,...
Published: 9/15/2025   |   Updated: 9/15/2025   |   Inventor(s): Qibing Pei, Ziqing Han, Isabelle Winardi
Keywords(s):  
Category(s): Electrical, Electrical > Electronics & Semiconductors, Materials, Materials > Nanotechnology, Materials > Functional Materials, Optics & Photonics, Optics & Photonics > Spectroscopy
Fiber Gel Scaffold for Cartilage Repair
­ PAGE TITLE Fiber Gel Scaffold for Cartilage Repair PAGE SUMMARY Successful repair of knee cartilage relies on an ideal integration of surgical technique and supportive scaffolds promoting cartilage formation. Existing commercial scaffolds are often associated with poor implant integration, sub-optimal cellular environment, and open surgery,...
Published: 2/12/2026   |   Updated: 9/4/2025   |   Inventor(s): Li-Hsin (Leo) Han, John Lawrence, Maurizio Pacifici
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors
AI-Based Wearable Sensor for Dermatology (Case No. 2025-301)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a flexible, cost-effective, AI-enabled wearable sensor that facilitates early, non-invasive diagnosis of allergic contact dermatitis. Background: Allergic contact dermatitis (ACD) is a hypersensitivity reaction of the skin triggered by direct contact...
Published: 3/11/2026   |   Updated: 8/25/2025   |   Inventor(s): Aydogan Ozcan, Shannon Wongvibulson, Paloma Casteleiro Costa, Gyeo-Re Han, Yuzhu Li
Keywords(s): Artificial Intelligence, artificial intelligence augmentation, artificial intelligence/machine learning models, Artificial Neural Network, artificial-intelligent materials, Computer-Aided Diagnosis, deep neural networks (DNN), Dermatology, electrochemical sensors, Medical artificial intelligence (AI), Signal Processing, Signal-To-Noise Ratio, Skin, skin protection, wearable, wearable electronics, wearable medical device, wearable medical devices, wearable sensors, wearable sensors for health
Category(s): Electrical, Electrical > Flexible Electronics, Electrical > Sensors, Medical Devices > Monitoring And Recording Systems, Therapeutics > Dermatology, Diagnostic Markers
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