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Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer
Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...
Published: 9/18/2024   |   Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji
Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics
Advanced PAI contrast agents for early cancer detection
This technology involves creating biodegradable nanoparticles (nanocapsules) that selectively target diseased cells, such as cancer cells, for imaging and treatment. These nanocapsules contain indocyanine green (ICG) dye aggre­gates, which are stable and offer high contrast when using near-infrared photo­acoustic imaging, enabling the detection...
Published: 8/2/2024   |   Inventor(s): Keith Johnston, Thomas Truskett, Ehsan Moaseri, Konstantin Sokolov, Sangheon Han, Behzad Changalvaie
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Therapeutics > Small molecule
Photoactivated Selective Release (PHASR) of Droplets from Microwell Arrays
A photoresponsive polymer layer that can be integrated into microfluidic devices for selective release of unique droplets Problem: Droplet microfluidics are used for single molecule detection and analysis, such as isolation of protein biomarkers for monitoring of disease progression. Current techniques for recovering unique molecules or cells from droplet...
Published: 8/2/2024   |   Inventor(s): Daeyeon Lee, Junhyong Kim, Yongwon Choi, Syung-Hun Han
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)
Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...
Published: 6/24/2024   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyou-Arm Joung, Dino Di Carlo
Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays
Antibodies against CD5L for therapeutic and diagnostic uses
Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer. UTHealth Ref. No.: 2020-0016 Inventors: Dr. Zhiqiang An and Dr. Ningyan Zhang at UTHealth; Dr. Anil Sood at UT M.D. Anderson Cancer Center Patent Status: PCT application PCT/US2021/025429...
Published: 5/28/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang, Anil Sood
Keywords(s):  
Category(s): Biologics, Oncology, Therapeutics
Nanocomposite Scintillators (Case No. 2024-126)
Summary: UCLA researchers from the Department of Materials Science and Engineering have developed a novel nanocomposite material for high-efficiency radiation detection and monitoring. Background: Scintillators are materials that emit light when they absorb radiation, such as gamma rays or x-rays. The photons generated by the scintillators can...
Published: 5/15/2024   |   Inventor(s): Qibing Pei, Ziqing Han
Keywords(s): adhesive material, Algorithm Optical Coherence Tomography, anode material, artificial electromagnetic materials, artificial-intelligent materials, background radiation, Biomaterial, Biomaterial 3D Printing, bulk material, Composite Material, composite scintillators, Computed tomography, Computerized Tomography scan (CT), Diffraction Tomography, Drug Delivery Microporous Material, fast scintillators, gamma spectroscopy, High resolution computed tomography, high-Z organometallics, hole transporting material, Hyperelastic Material, intercalated materials, material characterization, Materials, meta materials, metal nanocomposites, microarchitectured materials, nanocomposite scintillators, Nanocomposites, Nanomaterials, Nanoparticle, Nanoparticles, nanostructured materials, neutrino detection, Optical Tomography, Optoelectronic materials, photonic materials, positron emission tomography (PET), radiation detection, Raw materials supplier, scintillators, second harmonic generation, Smart Material, Solar Cell Metamaterial, Surgical Instrument Optical Coherence Tomography, suturable biomaterial, X-Ray Computed Tomography
Category(s): Chemical, Chemical > Chemical Sensors, Materials, Materials > Functional Materials
Stretchable hybrid response pressure sensor
Background Electronic skins, e-skins for short, is innovative soft electronics technology that gives robots and devices tactile sensing capabilities like human touch and feel. Robots equipped with human touch sensitivity could be deployed in many different applications ranging from manufacturing and food handling/preparation to medical care and surgery,...
Published: 6/28/2024   |   Inventor(s): Nanshu Lu, Kyoung-Ho Ha
Keywords(s):  
Category(s): Life sciences > Medical technology, Life sciences, Life sciences > Biomaterials, Computer software > Digital health, Computer software > Robotics
Modified Ionic Liquids for Thermal Properties in CubeSats
Inventors: Pradip Bhowmik His expertise includes Organic and Polymer Synthesis, Nanomaterials Synthesis, Green Chemistry, Ionic Liquids, Anticancer Drugs. The Invention: NASA requires the improvement of thermal management systems to regulate heat transfer among components within space vehicles or small spacecraft such as CubeSate. This disclosure...
Published: 4/9/2024   |   Inventor(s): Pradip Bhowmik, Haesook Han, Kevin Yu, Maksudul Alam
Keywords(s):  
Category(s): All
Producing Isotropic Super-Resolution Images from Line Scanning Confocal Microscopy
This technology includes a microscopy technique that produces super-resolution images from diffraction-limited images obtained from a line scanning confocal microscope. First, the operation of the confocal microscope is modified so that images with sparse line excitation are recorded. Second, these images are processed to increase resolution in one...
Published: 8/12/2024   |   Inventor(s): Hari Shroff, Yicong Wu, Patrick La Riviere, Xiaofei Han
Keywords(s):  
Category(s): Application > Medical Devices, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment
Multiview Super-resolution Microscopy System and Methods for Research and Diagnostic Applications
This technology includes a microscopy technique that combines the strengths of multiview imaging (better resolution isotropy, better depth penetration) with resolution-improving structured illumination microscopy (SIM). The proposed microscope uses a sharp line-focused illumination structure to excite and confocally detect sample fluorescence from 3...
Published: 8/12/2024   |   Inventor(s): Hari Shroff, Yicong Wu, Patrick La Riviere, Xiaofei Han
Keywords(s):  
Category(s): Application > Medical Devices, Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment
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