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High-Throughput Approach to Identify New Lipid Nanoparticle Formulations for Vaccine and Drug Delivery
High-throughput in vivo screening method to identify lipid nanoparticle (LNP) formulations for local and systemic delivery for mRNA vaccines and cancer immunotherapies. Problem: Nucleic acid delivery is an attractive and rapidly growing area of research, particularly for the development of vaccines and cancer immunotherapy. Historically, viral vectors...
Published: 12/20/2024   |   Inventor(s): Michael Mitchell, Alex Hamilton
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Gene Therapy, Immunology, Immunoncology, Immunotherapy, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Testing & Measurement, Technology Classifications > Vaccines, Technology Classifications > Therapeutics
Protein Function Scanning by Mass Spectrometry
High throughput, highly controlled mutagenesis method to study protein function of full-length proteins for protein engineering and testing, drug and antibody development, protein interaction and binding studies. Problem: Understanding a protein's functions requires studying each mutation separately through separation-of-function mutations. Traditional...
Published: 12/19/2024   |   Inventor(s): Roberto Bonasio, Julia Tasca
Keywords(s): Bioengineering, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
An Adaptive, Language-Agnostic, and Generalizable Method to Determine the Hearing Level and Speech Perception Abilities of a Patient
This hearing test is tuned to a patient’s hearing level and changes based on performance to accurately diagnose hearing ability Problem: Currently, no single hearing evaluation can determine multiple facets of an individual’s hearing ability. For example, some tests may determine hearing awareness at specific frequencies, but gather no data...
Published: 8/12/2024   |   Inventor(s): Jason Brant, Tiffany Hwa
Keywords(s): Aging, Neurodegenerative Diseases, Software, Surgery
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Testing & Measurement
High-Throughput and Independent Temperature Regulation In Biological Samples
A device that provides independent thermal regulation for biological samples in a 96-well microwell plate. Problem: Thermal control of cellular processes allows for remote control through tissue or opaque media, allowing for precise targeting of therapies in the body as well as broad control of metabolic processes in bioreactors. However, current...
Published: 6/6/2024   |   Inventor(s): Lukasz Bugaj, Brian Chow, William Benman, Zikang (Dennis) Huang
Keywords(s): Bioengineering, Platform Technology
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
A Precise, Analytical Model to Measure Visual Function and Monitor Retinal Disease
A model to estimate the change in photoreceptor outer segment length that occurs upon light stimulation – a biomarker of cone function in the retina. Problem: Vision relies on the isomerization of photopigments within photoreceptors (cones and rods) by light. Traditionally, researchers and clinicians have relied on functional assessments of photoreceptor...
Published: 3/6/2024   |   Inventor(s): Jessica Morgan, David Brainard, Raymond Warner
Keywords(s): Neurology, Ophthalmology
Category(s): Technology Classifications > Imaging, Technology Classifications > Diagnostics, Technology Classifications > Testing & Measurement
Ultrasensitive, High-Throughput, Single-Scale Detection of Extracellular Vesicles
An optofluidic platform to detect extracellular vesicles (EVs) at the single-particle level by parallelizing droplet generation and analysis of EVs. Problem: Extracellular vesicles (EVs) are lipid bound nanomaterials carrying various molecular cargo that can be representative of their cells of origin. EVs play a critical role in intercellular communication...
Published: 2/26/2024   |   Inventor(s): David Issadore, Zijian Yang
Keywords(s): Bioengineering, Microfluidics, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Double Digital Assay for Isolation and Analysis of Single Extracellular Vesicles for Early Detection of Disease Biomarkers Including Cancer
An ultrasensitive diagnostic tool that isolates single extracellular vesicles (EVs) and measures their contents to single molecule resolution. Problem: EVs contain biomolecules that can identify a variety of disease states and, thus, have emerged as a promising source for diagnostics. Within the EV diagnostic field, there are two major challenges:...
Published: 10/16/2023   |   Inventor(s): Jina Ko, David Reynolds, Menghan Pan
Keywords(s): Bioengineering, Infectious Disease, Microfluidics, Oncology, Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Research Tools & Reagents, Technology Classifications > Hardware & Components, Technology Classifications > Testing & Measurement
Cellulose Nanofiber-Based Substrates For Fabricating High-Fidelity And Biodegradable, Printed Electronics
A method for manufacturing biodegradable nano-cellulose infiltrated paper (NCIP) substrates with low surface smoothness and low porosity for printed electronics and packaging applications. Problem: Electronics and sensors today are typically fabricated on non-biodegradable substrates, which means they are poorly suited for a range of important uses...
Published: 10/16/2023   |   Inventor(s): Kevin Turner, Gokulanand Iyer, Gnana Vankayalapati
Keywords(s): Electronic Materials, Internet of Things
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Testing & Measurement, Technology Classifications > Agriculture & Environment
Design Of Artificial Proteins As Ultrafast, Genetically Encoded Electrophysiological Reporters
Rationally, computationally-driven designed maquette technology is a versatile platform for sensing electrophysical signals with customizable properties. Problem: Recording neuronal activity in vivo using optical methods can help to distinguish between normal and diseased brains. An ideal electrophysiological sensor would have a customizable structure...
Published: 1/5/2024   |   Inventor(s): Brian Chow, Peter Leslie Dutton, Christopher Moser, Bohdana Discher, Nathan Ennist
Keywords(s): Bioengineering, Neurology, Optics & Photonics , Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Business Ideas, Technology Classifications > Testing & Measurement
Pico-Washing: High Throughput Droplet Fluid-Exchange for Microfluidic Platforms
Device that simultaneously injects fluid into and removes fluid from droplets in flow. Problem: Droplet microfluidic technology is rapidly developing, unlocking newer high-throughput approaches in various fields including single-cell transcriptomics, genomics, and proteomics. One unit operation that remains underdeveloped in droplet microfluidics...
Published: 10/16/2023   |   Inventor(s): David Issadore, Michael Siedlik
Keywords(s): Bioengineering, Immunology, Infectious Disease, Microfluidics, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Hardware & Components, Technology Classifications > Testing & Measurement
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