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A Vaccine Technology for Preventing Clostridioides difficile Infection Using Cell Wall Protein 2 (CWP 2)

Advantages: A recombinant Cwp2 protein that induces strong IgG and IgA antibody response in animal models. Decrease levels of C. difficile spores and toxins in feces and decrease mortality rates in immunized mice. Anti-Cwp2 antibodies delay the binding of C. difficile vegetative cells to human gut epithelial cells and prevent bacterial colonization....

Published: 9/17/2024 | Inventor(s): Xingmin Sun, Shaohui Wang

Keywords(s): Vaccines

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology

Novel Nampt Activators and Synthesis Method for Cardiovascular and Aging-Related Diseases

Advantages: 2-Aminothiazole scaffold compounds are synthesized in aqueous condition, a practical and green approach. 3-component one-pot synthesis route with high reaction yield, shorter reaction time, and mild reaction conditions. Compounds are non-cytotoxic Nampt activators effective in promoting in vitro wound closure. Potential treatment...

Published: 7/23/2024 | Inventor(s): Kirpal Bisht, Srinivas Tipparaju

Keywords(s):

Category(s): zzCardiology, Technology Classifications > Medical > Pharmaceuticals

Ophthalmological Formulations for the Prevention of a Coronavirus Infection

Advantages: Directly delivers remdesivir in ophthalmic drops to the eye cells potentially minimizing systemic side effects. Formulation is designed to prevent disease transmission via the eyes and to treat conjunctivitis caused by infection. Nanoparticulate formulation meets pharmaceutical delivery standards. Summary: COVID-19, caused...

Published: 7/17/2024 | Inventor(s): Vijaykumar Sutariya, Srinivas Tipparaju, Kevin Sneed, Manas Biswal, Ozlem Guzeloglu-Kayisli, Ramesh Ayyala, Radouil Tzekov

Keywords(s):

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics

Drugs That Regulate Heparan Sulfate Expression for Cancer Treatment

Advantages: Developed a novel assay for identifying repurposed drugs targeting HS-related gene expression Revealed a dose-dependent inhibition of the HS-related gene EXT1 with Vitamin D/ Calcitriol EXT1 stable cell line with luciferase reporter ensures specificity in identifying EXT1 regulators, minimizing off-target effects Summary: Heparan...

Published: 9/3/2024 | Inventor(s): Lianchun Wang

Keywords(s): Biotechnology, Cancer Treatment, Medical Therapeutics Gene Therapy

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

Genistein For Asthma Prevention And Treatment

Advantages: The research focuses on a tailored approach for managing asthma, specifically on individuals with high PAI-1 genotypes. The research underscores the therapeutic potential of genistein in mitigating asthma severity and associated complications. In vitro and animal data support the efficacy of genistein in reducing allergic inflammation...

Published: 8/14/2024 | Inventor(s): Seong Cho, Raj Kumar, Brett Anderson, Michael Kaytor

Keywords(s): Respiratory Diseases Treatment

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Biotechnology

Soy Isoflavones For Asthma Prevention

Advantages: This research identified specific genetic markers (PAI-1 polymorphisms) linked to a significant reduction in asthma risk with soy isoflavone treatment. The research incorporates soy isoflavones into asthma management, leveraging the nutritional benefits of this natural compound and a holistic dietary path to respiratory wellness....

Published: 1/4/2024 | Inventor(s): Seong Cho, Raj Kumar

Keywords(s): Genetics, Respiratory Diseases Treatment

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Food Sciences

Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer

Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...

Published: 7/11/2024 | Inventor(s): Wishrawana Ratnayake, Kirpal Bisht, Mildred Acevedo-Duncan, Sloan Breedy, Aaron Todman, Luke Lajmi

Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Cancer

Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer

Published: 7/11/2024 | Inventor(s): Wishrawana Ratnayake, Mildred Acevedo-Duncan, Kirpal Bisht

Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer, Technology Classifications > Medical > Pharmaceuticals

New natural product scaffolds with activity against respiratory syncytial virus from the Antarctic Sponge Suberites sp.

Advantages: This research introduces a novel class of compounds, including neosuberitenone, which demonstrates selectivity against respiratory syncytial virus (RSV). The research's focus on small molecules derived from a natural source, the Antarctic sponge Suberites sp., hints at the potential for cost-effective treatments. The identified...

Published: 3/20/2024 | Inventor(s): Bill Baker, Joe Bracegirdle, Stine Olsen, Michael Teng, Kim Tran, Charles Amsler, James McClintock

Keywords(s): Antiviral Therapeutics, Infectious Diseases Treatment, Respiratory Diseases Treatment

Targeting CREB-Heparan Sulfate Pathway for Cancer Treatment

Advantages: This research contributes to a better understanding of the molecular mechanisms underlying the development and progression of PCa. The study identifies a specific signaling pathway involving Pten loss, CREB, and HS that plays a crucial role in promoting prostate tumorigenesis. The study explores potential therapeutic interventions,...

Published: 9/19/2024 | Inventor(s): Hua Yang, Lianchun Wang

Keywords(s): Cancer Treatment

Category(s): Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics

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