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Novel Potential Treatment for Glioblastoma Multiforme (GBM) via Potent Inhibitor of Atypical Protein Kinase C-iota
Advantages: ICA-1S uniquely inhibits aPKC-ι and Connexin 43, critical proteins in Glioblastoma Multiforme progression Significantly reduces glioblastoma cell proliferation, demonstrating superior efficacy compared to current chemotherapy agents Overcome therapeutic resistance by targeting Connexin 43, enhancing responsiveness to treatment Addressing...
Published: 3/25/2025   |   Inventor(s): Mildred Acevedo-Duncan, Grazielly Teodoro
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Ketone for Weight Loss Maintenance
Advantages: R/S 1,3-butanediol diacetoacetate clinically demonstrated superior weight loss compared to standard rodent chow or ketogenic diet Long-lasting weight maintenance suggests metabolic adaptations compared to typical diet-based approaches Scalable and cost-effective single-agent solution, offering a financial advantage over existing options Summary: Achieving...
Published: 2/26/2025   |   Inventor(s): Dominic D'Agostino, Angela Poff, Andrew Koutnik
Keywords(s): Nutrition / Diet Health
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry
Antimicrobial Terpenes From a Deep-Sea Irish Coral
Advantages: A novel structural diversity (anthoteibinenes A-Q) offers bioactive scaffolds, absent in standard combinatorial chemistry libraries Anthoteibinenes I and J have demonstrated activity against multiple Candida strains, indicating possible antibacterial efficacy Selective bioassay- and NMR-guided isolation provides a more targeted approach...
Published: 2/21/2025   |   Inventor(s): Bill Baker, Stine Olsen, Mark Johnson, Louise Allcock, Sam Afoullouss, Ezequiel Rosa, Ryan Young
Keywords(s):  
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals
Prevention of Abnormal Uterine Bleeding Caused by Progestin-Only Long-Acting Reversible Contraceptives
Advantages: 15dPGJ2 blocks the proliferation of human endometrial endothelial cells, thereby preventing pLARC-induced aberrant endometrial angiogenesis, a major cause of unexpected uterine bleeding 15dPGJ2 enhances progestin responsiveness and prevents pLARC-induced inflammation, another contributor to uterine vascular instability, effectively reducing...
Published: 2/19/2025   |   Inventor(s): Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical, Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals
Anti-Thrombin Nanoparticles and Therapeutics to Treat Necrotizing Enterocolitis
Advantages: Bivalirudin-tagged nanoparticles bind and neutralize nascent thrombin in clots, minimizing systemic anticoagulant effects Anti-thrombin nanoparticle confines its anticoagulant activity to sites of clot formation, limiting excessive systemic coagulation inhibition Dual therapeutic and diagnostic potential allows clinicians to treat NEC...
Published: 2/5/2025   |   Inventor(s): Akhil Maheshwari, Samuel Wickline, Koppenruncholan Namachivayam, Hua Pan
Keywords(s): Gastrointestinal / Digestive Health, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals
SLURP1 is a Novel Therapeutic Target for Ocular Surface Inflammatory Disorders
Advantages: Identification and validation of SLURP1 as a therapeutic target for treating ocular therapies SLURP1 enhances antioxidant defenses SLURP1 counteracts TGF-β-induced EMT in corneal epithelial cells Potential for Formulating eye care products with SLURP1 to mitigate oxidative stress and maintain corneal epithelial homeostasis (e.g....
Published: 1/24/2025   |   Inventor(s): Shivalingappa Swamynathan, Sudha Swamynathan, Satinder Kaur
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology
New Target for Heart Failure Therapies: Modifying MRPS5/ATF4 Signaling in Cardiomyocytes
Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...
Published: 1/17/2025   |   Inventor(s): Da-Zhi Wang, John Mably
Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals
Sensitive and Selective Synthetic Glucose Receptor Designed for Monitoring in Biomedical and Diagnostic Applications
Advantages: Highly sensitive glucose sensor with strong potential for use in biomedical diagnostics and continuous glucose monitoring. Flexible, adaptive binding pocket that selectively targets glucose’s functional groups, improving specificity and detection accuracy. Reversible, non-covalent binding to glucose, allowing real-time response...
Published: 1/17/2025   |   Inventor(s): Wenqi Liu
Keywords(s): Biotechnology, Diabetes, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical
Treating Age-Related Hearing Loss with Rapamycin and Its Derivatives
Advantages: Novel Application of FDA approved drugs, rapamycin and its derivatives, for treating age-related hearing loss (ARHL). Targeting mTOR alleviates oxidative stress and inflammation in the cochlea, enhancing cellular health and resilience to age-related damage. Potential to Reverse or Delay Age-related hearing loss (ARHL) in patients. Summary: Age-related...
Published: 1/17/2025   |   Inventor(s): Robert Frisina, Xiaohua Zhu, Bo Ding, Xiaoxia Zhu
Keywords(s): Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices
Antiviral Properties of Deep-Sea Coral Metabolites
Advantages: A novel compound for developing new antiviral drugs extracted from the Irish deep-sea soft coral Anthoteibinene B exhibits significant antiviral activity against Respiratory Syncytial Virus (RSV) without cytotoxic effects N,N-dimethylaminoethyl substituents further enhance antiviral properties by improving solubility, bioavailability,...
Published: 11/7/2024   |   Inventor(s): Bill Baker, Stine Olsen, Sam Afoullouss, Kim Teng, Michael Teng, Louise Allcock, Mark Johnson
Keywords(s): Antiviral Therapeutics
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics
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