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Novel Heart Failure Therapy: Farnesyltransferase Inhibition Targets Protein Aggregation in Cardiomyocytes
Advantages First-in-Class Mechanism: Targets a novel pathway—protein farnesylation—for heart failure treatment. Broad Therapeutic Potential: Effective in both HFrEF and HFpEF, addressing a major unmet need. Tested in multiple preclinical models: Danon disease cardiomyopathy (genetic model); HFpEF (diet-induced and hypertensive models);...
Published: 9/11/2025   |   Inventor(s): Kunhua Song, Congwu Chi, Amanda Conniff
Keywords(s): Cardiovascular Diseases, Drug Repurpose, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry
A Novel Immunomodulatory Strategy for Treating Heart Failure in Aging Populations
Advantages Novel Mechanism of Action: Targets the Th17/IL17A signaling axis Validated Target: IL17A is already clinically validated in other inflammatory diseases (e.g., psoriasis, psoriatic arthritis), with FDA-approved therapies like secukinumab Strong Preclinical POC: transcriptomic, histological, and functional cardiac assessments showing reversal...
Published: 8/25/2025   |   Inventor(s): Wanling Xuan, Srinivas Tipparaju
Keywords(s): Cardiological Diseases Treatment, Cardiovascular Diseases, Drug Discovery
Category(s): zzCardiology, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Spatiotemporal Drug Control in Autoimmune and Inflammatory Diseases: Photoswitchable JAK2 Inhibitors for Reversible Kinase Modulation
Advantages Precise spatiotemporal control and reversible modulation of kinase activity Reduced systemic toxicity and off-target effects Superior binding affinity and isomer selectivity than traditional Jak 2 inhibitor Summary Janus kinase 2 (JAK2), a key player in hematologic cancers and autoimmune diseases, is a particularly challenging target...
Published: 9/11/2025   |   Inventor(s): Shelby Kell, Chavdar Slavov
Keywords(s): Autoimmune Diseases, Inflammatory Diseases, Small Molecules, Therapeutics
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Methionine Sulfoxide Reductase A (MsrA) Gene Therapy for Retinal Degeneration
Advantaages Targeted Protection Against Oxidative Stress Dual-Vector Delivery System (AAV and Lenti) Simple and scalable plasmid design for efficient production Suitable for major ophthalmology indications: Age-related macular degeneration (AMD), Retinitis pigmentosa, other oxidative stress-related retinal degenerations Summary Oxidative stress...
Published: 8/18/2025   |   Inventor(s): Manas Biswal
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
FLR: A Triple-Target Fusion Vaccine Candidate Against Clostridioides difficile
Advantages Multi-Antigen Targeting for Broad Protection: targets three distinct virulence factors (FliC, LP2, RBD2) simultaneously Targeting Hypervirulent Strain Pathogenesis Significant protection from infection and weight loss Reduced fecal toxin and spore levels Summary Clostridioides difficile (C. difficile) is a bacterium that colonizes...
Published: 8/7/2025   |   Inventor(s): Xingmin Sun
Keywords(s): Infectious Diseases Treatment, Vaccines
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering
Regenerative Extracellular Vesicle (EV) Therapy for Sarcopenia: A Cell-Free Solution for Muscle Aging
Advantages Rejuvenates aged muscle tissue: restoring to youthful state while enhancing muscle mass and strength. Reduces muscle fiber degeneration and inflammation: healthier and more effective muscle regeneration. Effectively reverses age-associated alterations in muscle stem cells (MuSCs), outperforming PBS treatment in aged mice models. Summary Sarcopenia...
Published: 9/11/2025   |   Inventor(s): Wanling Xuan
Keywords(s): Drug Discovery, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Precision Peptides for Hearing and Beyond: Targeted Modulation of BK Channels
Advantages Crosses the blood-brain barrier High Specificity and Potency with an IC₅₀ in the low picomolar range Shows reduced side effects associated with anti-BK channel activity Possesses multiple pharmacological activities Summary Age-related hearing loss (ARHL) or presbycusis, affects over 50% of individuals aged 75 and older, impairing...
Published: 7/18/2025   |   Inventor(s): Luisa Scott, Joseph Walton
Keywords(s): Auditory/Hearing
Category(s): Technology Classifications > Medical > Pharmaceuticals
Multivalent Immunogens Against Clostridium Difficile
Advantages Effective against new and recurrent C. difficile infection Targets both C. difficile virulent factors TcdA and TcdB Prevents C. difficile colonization Vaccinations with fusion proteins protect animals against infection with an epidemic C. difficile strain Summary Globally, CDI remains an urgent public health problem. In the United...
Published: 6/12/2025   |   Inventor(s): Xingmin Sun
Keywords(s):  
Category(s): Technology Classifications > Medical > Pharmaceuticals
Novel Malaria Vaccine Candidates: CSP- Nanoparticle Vaccine Candidates for Plasmodium vivax
Advantages Enhanced Immunogenicity: Nanoparticles (NPs) boost immune responses compared to conventional subunit vaccines Broad Protection: Focusing on conserved regions of CSP, the vaccine elicits cross-reactive antibodies that may protect against multiple P. vivax strains Functional Efficacy: Generated antibodies inhibit sporozoite invasion of...
Published: 6/6/2025   |   Inventor(s): Francis Ntumngia, John Adams
Keywords(s): Vaccines
Category(s): Technology Classifications > Medical > Pharmaceuticals
Drug Loading of Donor Corneas for Corneal Transplantation
Advantages Provides a preventative approach to improving vision and reducing post-procedure complications Does not compromise or change donor tissue quality or viability Can be accomplished with a variety of techniques available in the market Drug dose and release can be controlled to meet patient specific needs Summary Partial and full thickness...
Published: 5/28/2025   |   Inventor(s): Christopher Passaglia, Edgar Espana, Emily Checchio
Keywords(s): Ophthalmology, Organ Transplantation
Category(s): Technology Classifications > Medical > Surgery, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Therapeutics
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