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Novel Therapeutic Target to Promoting Cardiomyocyte Proliferation and Enhance Cardiac Regeneration for Myocardial Injury and Disease
Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...
Published: 11/22/2024   |   Inventor(s): Da-Zhi Wang, John Mably
Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals
Pyridinium-Based Cyclophanes as Synthetic Lectins and Their Use for Glucose Recognition and Sensing in Aqueous Solutions
Advantages: Highly sensitive glucose sensor with strong potential for use in biomedical diagnostics and continuous glucose monitoring. Flexible, adaptive binding pocket that selectively targets glucose’s functional groups, improving specificity and detection accuracy. Reversible, non-covalent binding to glucose, allowing real-time response...
Published: 11/8/2024   |   Inventor(s): Wenqi Liu
Keywords(s): Biotechnology, Diabetes, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical
Targeting mTOR-Related Autophagy Dysfunction to Treat Age-Related Hearing Loss with Rapamycin and Its Derivatives
Advantages: Novel Application of FDA approved drugs, rapamycin and its derivatives, for treating age-related hearing loss (ARHL). Targeting mTOR alleviates oxidative stress and inflammation in the cochlea, enhancing cellular health and resilience to age-related damage. Potential to Reverse or Delay Age-related hearing loss (ARHL) in patients. Summary: Age-related...
Published: 11/5/2024   |   Inventor(s): Robert Frisina, Xiaohua Zhu, Bo Ding, Xiaoxia Zhu
Keywords(s): Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices
Antiviral Properties of Deep-Sea Coral Metabolites
Advantages: A novel compound for developing new antiviral drugs extracted from the Irish deep-sea soft coral Anthoteibinene B exhibits significant antiviral activity against Respiratory Syncytial Virus (RSV) without cytotoxic effects N,N-dimethylaminoethyl substituents further enhance antiviral properties by improving solubility, bioavailability,...
Published: 11/7/2024   |   Inventor(s): Bill Baker, Stine Olsen, Sam Afoullouss, Kim Teng, Michael Teng, Louise Allcock, Mark Johnson
Keywords(s): Antiviral Therapeutics
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics
A Vaccine Technology for Preventing Clostridioides difficile Infection Using Cell Wall Protein 2 (CWP 2)
­Advantages: A recombinant Cwp2 protein that induces strong IgG and IgA antibody response in animal models. Decrease levels of C. difficile spores and toxins in feces and decrease mortality rates in immunized mice. Anti-Cwp2 antibodies delay the binding of C. difficile vegetative cells to human gut epithelial cells and prevent bacterial colonization....
Published: 9/17/2024   |   Inventor(s): Xingmin Sun, Shaohui Wang
Keywords(s): Vaccines
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Medical > Biotechnology
Novel Nampt Activators and Synthesis Method for Cardiovascular and Aging-Related Diseases
­Advantages: 2-Aminothiazole scaffold compounds are synthesized in aqueous condition, a practical and green approach. 3-component one-pot synthesis route with high reaction yield, shorter reaction time, and mild reaction conditions. Compounds are non-cytotoxic Nampt activators effective in promoting in vitro wound closure. Potential treatment...
Published: 7/23/2024   |   Inventor(s): Kirpal Bisht, Srinivas Tipparaju
Keywords(s):  
Category(s): zzCardiology, Technology Classifications > Medical > Pharmaceuticals
Ophthalmological Formulations for the Prevention of a Coronavirus Infection
­Advantages: Directly delivers remdesivir in ophthalmic drops to the eye cells potentially minimizing systemic side effects. Formulation is designed to prevent disease transmission via the eyes and to treat conjunctivitis caused by infection. Nanoparticulate formulation meets pharmaceutical delivery standards. Summary: COVID-19, caused...
Published: 7/17/2024   |   Inventor(s): Vijaykumar Sutariya, Srinivas Tipparaju, Kevin Sneed, Manas Biswal, Ozlem Guzeloglu-Kayisli, Ramesh Ayyala, Radouil Tzekov
Keywords(s):  
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics
Drugs That Regulate Heparan Sulfate Expression for Cancer Treatment
­Advantages: Developed a novel assay for identifying repurposed drugs targeting HS-related gene expression Revealed a dose-dependent inhibition of the HS-related gene EXT1 with Vitamin D/ Calcitriol EXT1 stable cell line with luciferase reporter ensures specificity in identifying EXT1 regulators, minimizing off-target effects Summary: Heparan...
Published: 11/25/2024   |   Inventor(s): Lianchun Wang
Keywords(s): Biotechnology, Cancer Treatment, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Genistein For Asthma Prevention And Treatment
­Advantages: The research focuses on a tailored approach for managing asthma, specifically on individuals with high PAI-1 genotypes. The research underscores the therapeutic potential of genistein in mitigating asthma severity and associated complications. In vitro and animal data support the efficacy of genistein in reducing allergic inflammation...
Published: 8/14/2024   |   Inventor(s): Seong Cho, Raj Kumar, Brett Anderson, Michael Kaytor
Keywords(s): Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Biotechnology
Soy Isoflavones For Asthma Prevention
­Advantages: This research identified specific genetic markers (PAI-1 polymorphisms) linked to a significant reduction in asthma risk with soy isoflavone treatment. The research incorporates soy isoflavones into asthma management, leveraging the nutritional benefits of this natural compound and a holistic dietary path to respiratory wellness....
Published: 1/4/2024   |   Inventor(s): Seong Cho, Raj Kumar
Keywords(s): Genetics, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Food Sciences
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