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Regenerative Extracellular Vesicle (EV) Therapy for Sarcopenia: A Cell-Free Solution for Muscle Aging
Advantages Rejuvenates aged muscle tissue: restoring to youthful state while enhancing muscle mass and strength. Reduces muscle fiber degeneration and inflammation: healthier and more effective muscle regeneration. Effectively reverses age-associated alterations in muscle stem cells (MuSCs), outperforming PBS treatment in aged mice models. Summary Sarcopenia...
Published: 7/23/2025   |   Inventor(s): Wanling Xuan
Keywords(s): Drug Discovery, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Precision Peptides for Hearing and Beyond: Targeted Modulation of BK Channels
Advantages Crosses the blood-brain barrier High Specificity and Potency with an IC₅₀ in the low picomolar range Shows reduced side effects associated with anti-BK channel activity Possesses multiple pharmacological activities Summary Age-related hearing loss (ARHL) or presbycusis, affects over 50% of individuals aged 75 and older, impairing...
Published: 7/18/2025   |   Inventor(s): Luisa Scott, Joseph Walton
Keywords(s): Auditory/Hearing
Category(s): Technology Classifications > Medical > Pharmaceuticals
Multivalent Immunogens Against Clostridium Difficile
Advantages Effective against new and recurrent C. difficile infection Targets both C. difficile virulent factors TcdA and TcdB Prevents C. difficile colonization Vaccinations with fusion proteins protect animals against infection with an epidemic C. difficile strain Summary Globally, CDI remains an urgent public health problem. In the United...
Published: 6/12/2025   |   Inventor(s): Xingmin Sun
Keywords(s):  
Category(s): Technology Classifications > Medical > Pharmaceuticals
Novel Malaria Vaccine Candidates: CSP- Nanoparticle Vaccine Candidates for Plasmodium vivax
Advantages Enhanced Immunogenicity: Nanoparticles (NPs) boost immune responses compared to conventional subunit vaccines Broad Protection: Focusing on conserved regions of CSP, the vaccine elicits cross-reactive antibodies that may protect against multiple P. vivax strains Functional Efficacy: Generated antibodies inhibit sporozoite invasion of...
Published: 6/6/2025   |   Inventor(s): Francis Ntumngia, John Adams
Keywords(s): Vaccines
Category(s): Technology Classifications > Medical > Pharmaceuticals
Drug Loading of Donor Corneas for Corneal Transplantation
Advantages Provides a preventative approach to improving vision and reducing post-procedure complications Does not compromise or change donor tissue quality or viability Can be accomplished with a variety of techniques available in the market Drug dose and release can be controlled to meet patient specific needs Summary Partial and full thickness...
Published: 5/28/2025   |   Inventor(s): Christopher Passaglia, Edgar Espana, Emily Checchio
Keywords(s): Ophthalmology, Organ Transplantation
Category(s): Technology Classifications > Medical > Surgery, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Therapeutics
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Novel PCR-Based Blood Test to Predict Mortality and Monitor Treatment Response for Idiopathic Pulmonary Fibrosis
Advantages IPF Biomarker assay: 6-gene transcriptomic signature strongly correlates with disease severity and mortality across multiple patient cohorts and sample types Non-Invasive Testing: PCR test requires only a blood sample Potential for Precision-Based Therapies: gene-signature panel opens avenues to test targeted therapeutic interventions Identification...
Published: 6/2/2025   |   Inventor(s): Jose Herazo-Maya, Theodoros Karampitsakos
Keywords(s): Medical Diagnostics, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Pharmaceuticals
Novel Combination Treatment for Glioblastoma
Advantages: Temozolomide (TMZ), Cannabidiol (CBD), and CCR6/CCL20 inhibitors work together to overcome Glioblastoma resistance and enhance efficacy Targeted CCL20/CCR6 inhibition blocks survival pathways in glioblastoma, reducing resistance and relapse while improving outcomes Enhances CD8+ T cells and rewires immunity, offering powerful, lasting...
Published: 4/30/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Ryan Green, Karthick Mayilsamy
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells
Advantages: Minimally invasive secretome therapy enhances Schlemm’s canal function, offering a non-surgical alternative to glaucoma treatment Secretome therapy promotes cellular repair and wound healing, addressing TM damage beyond Increased Intraocular Pressure (IOP) reduction Secretome therapy enhances aqueous outflow by upregulating tight...
Published: 4/17/2025   |   Inventor(s): Rong Du, Yiqin Du, Enzhi Yang
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Chemistry
Novel Potential Treatment for Glioblastoma Multiforme (GBM) via Potent Inhibitor of Atypical Protein Kinase C-iota
Advantages: ICA-1S uniquely inhibits aPKC-ι and Connexin 43, critical proteins in Glioblastoma Multiforme progression Significantly reduces glioblastoma cell proliferation, demonstrating superior efficacy compared to current chemotherapy agents Overcome therapeutic resistance by targeting Connexin 43, enhancing responsiveness to treatment Addressing...
Published: 7/7/2025   |   Inventor(s): Mildred Acevedo-Duncan, Grazielly Teodoro
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Oncology
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