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Drug Loading of Donor Corneas for Corneal Transplantation
Advantages Provides a preventative approach to improving vision and reducing post-procedure complications Does not compromise or change donor tissue quality or viability Can be accomplished with a variety of techniques available in the market Drug dose and release can be controlled to meet patient specific needs Summary Partial and full thickness...
Published: 5/28/2025   |   Inventor(s): Christopher Passaglia, Edgar Espana, Emily Checchio
Keywords(s): Ophthalmology, Organ Transplantation
Category(s): Technology Classifications > Medical > Surgery, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Therapeutics
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Novel PCR-Based Blood Test to Predict Mortality and Monitor Treatment Response for Idiopathic Pulmonary Fibrosis
Advantages Prognostic biomarker assay: Easy PCR blood tests to determine 6-gene signature as an accurate method to stratify IPF patient severity and predict mortality Potential for Precision-Based Therapies: gene-signature panel opens avenues to test targeted therapeutic interventions Identification of Drug Candidates: Identified several drug categories...
Published: 5/22/2025   |   Inventor(s): Jose Herazo-Maya, Theodoros Karampitsakos
Keywords(s): Medical Diagnostics, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Pharmaceuticals
Novel Combination Treatment for Glioblastoma
Advantages: Temozolomide (TMZ), Cannabidiol (CBD), and CCR6/CCL20 inhibitors work together to overcome Glioblastoma resistance and enhance efficacy Targeted CCL20/CCR6 inhibition blocks survival pathways in glioblastoma, reducing resistance and relapse while improving outcomes Enhances CD8+ T cells and rewires immunity, offering powerful, lasting...
Published: 4/30/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Ryan Green, Karthick Mayilsamy
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells
Advantages: Minimally invasive secretome therapy enhances Schlemm’s canal function, offering a non-surgical alternative to glaucoma treatment Secretome therapy promotes cellular repair and wound healing, addressing TM damage beyond Increased Intraocular Pressure (IOP) reduction Secretome therapy enhances aqueous outflow by upregulating tight...
Published: 4/17/2025   |   Inventor(s): Rong Du, Yiqin Du, Enzhi Yang
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Chemistry
Novel Potential Treatment for Glioblastoma Multiforme (GBM) via Potent Inhibitor of Atypical Protein Kinase C-iota
Advantages: ICA-1S uniquely inhibits aPKC-ι and Connexin 43, critical proteins in Glioblastoma Multiforme progression Significantly reduces glioblastoma cell proliferation, demonstrating superior efficacy compared to current chemotherapy agents Overcome therapeutic resistance by targeting Connexin 43, enhancing responsiveness to treatment Addressing...
Published: 5/29/2025   |   Inventor(s): Mildred Acevedo-Duncan, Grazielly Teodoro
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Ketone for Weight Loss Maintenance
Advantages: R/S 1,3-butanediol diacetoacetate clinically demonstrated superior weight loss compared to standard rodent chow or ketogenic diet Long-lasting weight maintenance suggests metabolic adaptations compared to typical diet-based approaches Scalable and cost-effective single-agent solution, offering a financial advantage over existing options Summary: Achieving...
Published: 2/26/2025   |   Inventor(s): Dominic D'Agostino, Angela Poff, Andrew Koutnik
Keywords(s): Nutrition / Diet Health
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry
Antimicrobial Terpenes From a Deep-Sea Irish Coral
Advantages: A novel structural diversity (anthoteibinenes A-Q) offers bioactive scaffolds, absent in standard combinatorial chemistry libraries Anthoteibinenes I and J have demonstrated activity against multiple Candida strains, indicating possible antibacterial efficacy Selective bioassay- and NMR-guided isolation provides a more targeted approach...
Published: 2/21/2025   |   Inventor(s): Bill Baker, Stine Olsen, Mark Johnson, Louise Allcock, Sam Afoullouss, Ezequiel Rosa, Ryan Young
Keywords(s):  
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical, Technology Classifications > Medical > Pharmaceuticals
Prevention of Abnormal Uterine Bleeding Caused by Progestin-Only Long-Acting Reversible Contraceptives
Advantages: 15dPGJ2 blocks the proliferation of human endometrial endothelial cells, thereby preventing pLARC-induced aberrant endometrial angiogenesis, a major cause of unexpected uterine bleeding 15dPGJ2 enhances progestin responsiveness and prevents pLARC-induced inflammation, another contributor to uterine vascular instability, effectively reducing...
Published: 2/19/2025   |   Inventor(s): Charles Lockwood, Ozlem Guzeloglu-Kayisli, Umit Kayisli
Keywords(s): Women’s Health
Category(s): Technology Classifications > Medical, Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals
Anti-Thrombin Nanoparticles and Therapeutics to Treat Necrotizing Enterocolitis
Advantages: Bivalirudin-tagged nanoparticles bind and neutralize nascent thrombin in clots, minimizing systemic anticoagulant effects Anti-thrombin nanoparticle confines its anticoagulant activity to sites of clot formation, limiting excessive systemic coagulation inhibition Dual therapeutic and diagnostic potential allows clinicians to treat NEC...
Published: 2/5/2025   |   Inventor(s): Akhil Maheshwari, Samuel Wickline, Koppenruncholan Namachivayam, Hua Pan
Keywords(s): Gastrointestinal / Digestive Health, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals
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