Search Results - formulation

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Formulation of a Modified Stable FGF-1 (TTHX1114) to Accelerate Corneal Endothelium Regeneration
This technology includes the use of a novel formulation for an engineered version of Fibroblast Growth Factor 1 (FGF1), TTHX1114, that can be used to accelerate regeneration of the corneal endothelium after surgical lesions. FGFs are well-established regulators of migration and proliferation of corneal endothelial cells (CECs).
Published: 7/25/2024   |   Inventor(s): Vinay Vyas, Hui Fang Dong, Asaf Alimardanov, Gautam ("George") Mitra, Trevor Broadt, David Eveleth
Keywords(s): FGF-1, FORMULATION, Modified, PRESERVATION, STABLE, TTHX1114, VPXXXX, WIXXXX, WKXXXX, XEXXXX
Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Ophthalmology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Research Materials, TherapeuticArea > Cardiology
Pre-Biotic Formulation of Topical Chemicals for Use on Human Skin
Atopic dermatitis (AD) is a common, recurrent, chronic inflammatory skin disease that is a cause of considerable economic and social burden. It is one of the most prevalent skin disorders, affecting ~25% of children in developed and developing countries and is expected to continue to escalate. This increased rate of incidence has changed the focus of...
Published: 7/25/2024   |   Inventor(s): Carlo Castillo, Ian Myles
Keywords(s): CHEMICALS, FORMULATION, Human, Pre-biotic, SKIN, TOPICAL
Category(s): Collaboration Sought > Collaboration
Co-polymer Stabilizers for Pressured Metered Dose Inhalers (pMDIs)
A series of novel co polymer surfactants with the general structure LAmEOnLAm were developed along with a Colloidal Probe Microscopy (CPM) method to optimize the surfactant composition using adhesion forces to improve stabilization of drug dispersions. This expands the range of biomolecules and micronized drug particles that can be formulated with pMDIs....
Published: 11/11/2021   |   Inventor(s): Sandro Da Rocha, Libo Wu
Keywords(s): Assay, Asthma, Compound, Device, Drug Delivery, Formulation, Instrumentation, Method, Pharmaceuticals, Process, Therapeutics
Category(s): Chemicals, Drug Delivery, Pharmaceuticals, Instrumentation, Materials
Nanoparticle Method to Stabilize Suspension-Based pMDI HFA Formulations
Novel nanoparticle-based drug compositions and methods that improve and expand therapeutic drug delivery to the lungs through pressurized meter-dose inhalers (pMDIs). A large variety of approaches have been developed at WSU aimed at improving the aerosol characteristics and expanding the range of target species deliverable. These improved formulations...
Published: 11/11/2021   |   Inventor(s): Sandro Da Rocha, Libo Wu
Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals
Category(s): Drug Delivery, Life Science, Nano-based, Therapeutics
Dual action nanocarrier combining CXCR4 antagonist and polyplex gene delivery for treatment of metastatic cancer and other diseases
Novel bio-reducible polymer compositions which combine the ability to act as a CXCR4 antagonist and simultaneously provide enhanced gene delivery through the formation of inert nanocarrier polyplexes have been developed. As would be expected for biodegradable polymers, the cytotoxicity of these nanocarrier compositions are very low with measured IC50...
Published: 11/11/2021   |   Inventor(s): David Oupicky, Jing Li
Keywords(s): Cancer, Cancer Therapies, Compound, Drug Delivery, Drug Target, Formulation, Imaging, Nanomaterials, Pharmaceuticals, Therapeutics
Category(s): Drug Delivery, Gene Therapy, Therapeutics, Life Science, Oncology, Nano-based, Metabolic disorders, Biologicals
Improved pDMI Inhaler Formulations
Novel biodegradable, non-toxic nanoparticles that act as stabilizing excipients with a wide variety of suspension drug candidates including polar & non-polar drug particles, bio-macromolecules (proteins/peptides), gene therapies (DNA/siRNA) as well as amorphous and crystalline therapeutics have been developed which provide a platform for improving...
Published: 11/11/2021   |   Inventor(s): Sandro Da Rocha, Libo Wu
Keywords(s): Asthma, Drug Delivery, Formulation, Nanomaterials, Pharmaceuticals, Therapeutics
Category(s): Drug Delivery, Life Science, Therapeutics, Nano-based