Search Results - stephen+smith

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A microcontroller for easier whole-cell patch clamping on dendrites and axons
Summary The current technology is a microcontroller that allows for the application of controlled negative pressure and simultaneous electrical impulses to make it easier to obtain whole-cell patch clamp recordings on small cellular structures. Technology Overview Whole-cell patch clamping is a technique commonly employed to study the electrical...
Published: 1/30/2024   |   Inventor(s): Stephen Smith, Timur Tsintsadze
Keywords(s): Research Tools, Research Tools - Other
Category(s): Research Tools
Small Molecule Inhibitors of Drug Resistant Forms of HIV-1 Integrase
Abstract: Integrase strand transfer inhibitors (“INSTIs”) are currently in use as a component of prophylactic antiretroviral therapy for preventing HIV-1 infection from progressing to AIDS. Three INSTIs are approved by the FDA for inclusion in antiretroviral regiments: raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG). Clinicians have already...
Published: 5/22/2024   |   Inventor(s): Xue Zhao, Terrence Burke, Yves Pommier, Stephen Hughes, Mathieu Metifiot, Stephen Smith, Barry Johnson, Christophe Marchand
Keywords(s): dolutegravir, drug resistant HIV, elvitegravir, HIV therapy, Integrase, raltegravir, strand transfer
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing