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Search Results - barry+falgout
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Dengue Tetravalent Vaccine Containing a Common 30 Nucleotide Deletion in the 3'-UTR of Dengue Types 1, 2, 3, and 4
The invention relates to a dengue virus tetravalent vaccine containing a common 30-nucleotide deletion (delta30) in the 3'-untranslated region (UTR) of the genome of dengue virus serotypes 1, 2, 3, and 4. The previously identified delta30 attenuating mutation, created in dengue virus type 4 (DEN4) by the removal of 30 nucleotides from the 3'-UTR, is...
Published: 10/28/2024
|
Inventor(s):
Brian Murphy
,
Lewis Markoff
,
Barry Falgout
,
Kathryn Hanley
,
Joseph Blaney
,
Stephen Whitehead
Keywords(s):
3'-UTR
,
ANTIGENIC
,
chimeric
,
Chromosome 7, monosomy
,
DA4BXX
,
DA4XXX
,
DAXXXX
,
DB4BXX
,
DB4XXX
,
DBXXXX
,
DC5BXX
,
DC5XXX
,
DCXXXX
,
Deletion
,
Deletion 7
,
DENGUE
,
Dengue (Flaviviridae)
,
DXXXXX
,
Nucleotide
,
Tetravalent
,
UAXXXX
,
UBXXXX
,
Vaccine
,
Viruses
Category(s):
Collaboration Sought > Licensing
,
TherapeuticArea > Rare / Neglected Diseases
,
Application > Diagnostics
,
TherapeuticArea > Infectious Disease
,
Application > Therapeutics
,
Application > Vaccines