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Potent Nucleotide Inhibitors of Ecto-5'-Nucleotidase (CD73)
These small molecules are novel nucleotide derivatives, containing either a purine or pyrimidine nucleobase, that competitively block the enzyme CD73, also known as ecto-5'-nucleotidase. This enzyme converts extracellular AMP (not a potent activator of adenosine receptors) to adenosine (the native activator of 4 subtypes of adenosine receptors. CD73...
Published: 10/28/2024   |   Inventor(s): Christa Mueller, Anna Junker, Kenneth Jacobson
Keywords(s): CB5EXX, CD73, Ecto-5-nucleotidase, Inhibitors, Nucleotide, POTENT
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics