Search Results - anna+bulysheva

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Non-Contact, Painless Electroporation and Molecular Transfer Method
Advantages: Permeabilizes cell membranes and tissues without applying a current minimizes the risk of ventricular fibrillation, pain, muscle contractions, and twitching Achieves molecular delivery and cell ablation solely through voltage application, reducing treatment complexity and potential medication side effects Safer modality suitable for...
Published: 3/25/2025   |   Inventor(s): Anna Bulysheva, Alex Otten, Jacob Hensley
Keywords(s): Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Therapeutics
Multiphasic Localized in vivo Molecular Delivery
Advantages: Asymmetric biphasic pulses significantly reduced stimulation of skeletal muscle contractions in vivo and enhanced gene delivery Enables delivery of insulin and glucokinase to replace daily injections with long-term, non-immunogenic protein expression in skeletal muscle Higher-efficiency gene therapies avoid immunogenicity and off-target...
Published: 2/21/2025   |   Inventor(s): Anna Bulysheva, Mark Jaroszeski, Richard Heller
Keywords(s): Cancer Treatment, Drug Delivery Systems, Medical Therapeutics Gene Therapy, Wound and Tissue Healing
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Cancer, Technology Classifications > Medical > Biomedical Engineering
Localized In Vivo Electro Gene Therapy for Type 1 Diabetes
­Advantages: Novel gene therapy for Type 1 Diabetes (T1D) focused on reprogramming skeletal muscle cells to modulate glucose levels in vivo. Nano plasmid DNA of insulin and glucokinase decreased glucose levels in vitro and in vivo and enhanced insulin expression and secretion. Groundbreaking treatment for long-lasting blood glucose control...
Published: 1/14/2025   |   Inventor(s): Anna Bulysheva
Keywords(s): Diabetes, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology