Search Results - richard+heller

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Multiphasic Localized in vivo Molecular Delivery
Advantages: Asymmetric biphasic pulses significantly reduced stimulation of skeletal muscle contractions in vivo and enhanced gene delivery Enables delivery of insulin and glucokinase to replace daily injections with long-term, non-immunogenic protein expression in skeletal muscle Higher-efficiency gene therapies avoid immunogenicity and off-target...
Published: 2/21/2025   |   Inventor(s): Anna Bulysheva, Mark Jaroszeski, Richard Heller
Keywords(s): Cancer Treatment, Drug Delivery Systems, Medical Therapeutics Gene Therapy, Wound and Tissue Healing
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Cancer, Technology Classifications > Medical > Biomedical Engineering
Novel Device for Applying Electrically Based Therapeutics
­Advantages: Novel device to perform electrically based therapies for: soft tissue ablation (irreversible electroporation; IRE), Drug Delivery (electrochemotherapy; ECT), Gene delivery (gene electro transfer; GET). Modular array technology integrates temperature modulation to reduce voltage requirements, impedance monitoring to control applied...
Published: 8/27/2024   |   Inventor(s): Richard Heller, Mark Jaroszeski
Keywords(s):  
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Biomedical Engineering
Dual-mechanism PD1 (programmed death receptor 1) DNA Vaccine as a Checkpoint Inhibitor Therapy
Competitive Advantages Significant reduction of cost and number of treatments Provides a more personalized treatment Comparatively fewer side effects Summary­ Checkpoint inhibitor therapy involves infusion of antibodies against one or more checkpoints. This therapy is expensive and has potential side effects. The invention disclosed here...
Published: 7/11/2023   |   Inventor(s): Loree Heller, Richard Heller
Keywords(s): Antibodies, Biotechnology, Plasmids
Category(s): Technology Classifications > Medical > Biotechnology