Search Results - kevin+yehl

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DNAzyme Nanoparticles for the Cleavage of RNA
Application Site-selective RNA splicing nanozyme for cleaving and ligating RNA. Key Benefits Can cleave virtually any RNA stem loop. Removes a 19 nucleotide segment from a 67 nucleotide RNA loop with up to 66% efficiency. Technical Summary Modulating RNA can be useful for studying RNA biology, gene knockdown, and regulating RNA splicing. Scientists...
Published: 3/6/2025   |   Inventor(s): Jessica Petree, Kevin Yehl, Khalid Salaita
Keywords(s): Enzyme and Protein Research, Gene Therapy and Editing
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Micro and Nanotechnology
DNA Machines Enhance SNP Analysis Efficiency
Application DNA-based machines that roll rather than walk and can be used for single nucleotide polymorphism (SNP) analysis. Key Benefits Unique "rolling" cogwheel-like mechanism allows directional motion without a track or external guidance. Micron-sized cargo travels large distances; can be visualized using a smartphone camera equipped with...
Published: 2/13/2025   |   Inventor(s): Khalid Salaita, Kevin Yehl
Keywords(s): Chemistry, Enzyme and Protein Research
Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Research Tools
Therapeutic DNAzyme-Nanoparticle Conjugates for Gene Regulation
Application Catalytic DNA molecules (DNAzymes) conjugated to gold nanoparticles for use as therapeutics to treat cancers, infections or other applications of gene therapy. Key Benefits DNAzyme-gold nanoparticles regulate gene expression through an RNAi independent mechanism. Each DNAzyme-gold nanoparticle is more catalytically active than a free...
Published: 3/6/2025   |   Inventor(s): Khalid Salaita, Kevin Yehl
Keywords(s): Gene Therapy and Editing, Microbiology and Infectious Disease Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics