Search Results - weiming+luo

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Therapeutics for Neurodegenerative Disorders and Cancer Using Lenalidomide Analogs

Abstract: Inflammatory processes associated with the over-production of tumor necrosis-alpha (TNF-alpha), a potent activator of the immune system accompany numerous neurodegenerative diseases. TNF-alpha has been validated as a drug target with the development of the inhibitors Enbrel and Remicade (fusion antibodies) as prescription medications. Both,...

Published: 4/8/2024 | Inventor(s): Nigel Greig, Weiming Luo, David Tweedie, Harold Holloway, Qian-sheng Yu, Edward Goetzl

Keywords(s): CNS, Holloway, Immunomodulatory Agents, Inflammation, Lenalidomide, National Institute on Aging, Neurodegenerative Disorders, NIA, THALIDOMIDE, TNF-alpha, Tumor Necrosis-alpha

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Thalidomide Analogs that Inhibit Inflammation and Angiogenesis

Abstract: Thalidomide and its close analogs (lenalidomide and pomalidomide) are widely used to treat a variety of diseases, such as multiple myeloma and other cancers as well as the symptoms of several inflammatory disorders. However, thalidomide is known for its teratogenic adverse effects when first clinically introduced in the 1950s, and is associated...

Published: 4/8/2024 | Inventor(s): Nigel Greig, Weiming Luo, David Tweedie, Nell Vargesson, Shaunna Beedle, William Figg

Keywords(s): anti-angiogenesis, ANTI-INFLAMMATORY, Lenalidomide, Pomalidomide, THALIDOMIDE

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability

Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...

Published: 9/25/2023 | Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA

Keywords(s): Drug Discovery, Immunology

Category(s): Technology Classifications > Medical > Biotechnology

2014-9AG Wide-Field Computational Imaging of Pathology Slides Using Lensfree On-Chip Microscopy

Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a wide field-of-view (FOV) computational imaging method using lens-free on-chip microscopy to efficiently and cost-effectively scan biological samples such as pathology slides. Background: Wide field-of-view (FOV) and high-resolution imaging is crucial...

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Alon Greenbaum, Yibo Zhang, Alborz Feizi, Wei Luo

Category(s): Life Science Research Tools, Electrical, Electrical > Imaging, Life Science Research Tools > Microscopy And Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Medical Devices > Medical Imaging

2016-802 Demosaiced Pixel Super-Resolution for Multiplexed Holographic Color Imaging

SUMMARYUCLA researchers have developed a new high-resolution color microscopy technique termed Demosaiced Pixel Super-Resolution (D-PSR), which significantly improves the performance of holographic high-resolution color imaging.BACKGROUNDDigital holography refers to the acquisition and processing of holograms with a digital sensor array, typically a...

Published: 7/19/2023 | Inventor(s): Yibo Zhang, Aydogan Ozcan, Wei Luo, Yichen Wu

Keywords(s):

Category(s): Life Science Research Tools > Microscopy And Imaging, Medical Devices > Medical Imaging

2016-175 PIXEL SUPER-RESOLUTION USING WAVELENGTH SCANNING

Pixel Super-Resolution Using Wavelength ScanningSUMMARYUCLA researchers have developed a novel way to significantly improve the resolution of an undersampled or pixelated image.BACKGROUNDHigh-resolution imaging across a wide field-of-view (FOV) is essential for various applications in different fields. Current solutions either require imaging systems...

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Wei Luo

Keywords(s):

Category(s): Software & Algorithms > Image Processing

2015-153 SINGLE MOLECULE IMAGING AND SIZING OF DNA ON A MOBILE-PHONE

Single Molecule Imaging and Sizing of DNA on a Cell PhoneSUMMARYUCLA researchers in the Department of Electrical Engineering have developed a light-weight and cost-effective fluorescence microscope installed on a cell phone.BACKGROUNDOptical methods for imaging single biomolecules allow for exploration of their individual behavior and properties at...

Published: 7/19/2023 | Inventor(s): Aydogan Ozcan, Qingshan Wei, Wei Luo

Keywords(s):

Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging

Hybrid Plasmonic Platform for Directing and Controlling Nanostructure Growth

Low-Heat, Bottom-Up Approach Can Produce Metal, Polymer or Bio-Molecule Structures for Catalysis, Biosensors, Electronic Devices and MoreThis surface plasmon mediated chemical solution deposition method uses surface plasmon resonance to deposit nanoparticles in the liquid phase at room temperature to direct and control nanostructure growth. Plasmonic...

Published: 6/27/2021 | Inventor(s): Wei Wei, Jingjing Qiu

Keywords(s): Catalysts, nanoparticle synthesis, Plasmonic, Thin Films

Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials

Network-Coded Multiple Access

[Licensing negotiation in progress] [Invitation for Expression of Interest - Deadline: 16 June 2016] Systems and methods include a first wireless local area network (WLAN) system that jointly exploit physical-layer network coding (PNC) and multi-user decoding (MUD) to boost system throughput. This multiple access mode is referred to as Network-Coded...

Published: 1/29/2024 | Inventor(s): Soung Chang Liew, Lu LU, Lizhao You

Keywords(s): Network Coding, Wireless Local Area Network

Category(s): Information and Communications Technology

Erythropoietin-Derived Short Peptide and Its Mimics as Immuno/Inflammatory Modulators

Invention Summary: Erythropoeitin (Epo) is a hematopoietic growth factor widely used in the treatment of anemia and has been claimed to have direct neuroprotective effects. However, long-term Epo therapy can lead to the excessive elevation of platelets and red blood cells in non-anemic individuals. A short Epo-derived peptide has recently been shown...

Published: 5/9/2024 | Inventor(s): Rui Rong Yuan, Peter Dowling, Bo Wang, Wei Lu

Keywords(s): Neurological disorder & neuropathic pain

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics