Search Results - nigel+greig

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Fluorophthalimides as Anti-inflammatory Agents for Systemic and Neurodegenerative Disorder
Summary: The National Institute on Aging (NIA) seeks research co-development partners and/or licensees for the pre-clinical and clinical development of the compounds as anti-inflammatory therapeutics for systemic and neurodegenerative disorders. Description of Technology: Numerous systemic, as well as neurological disorders, have a hallmark inflammatory...
Published: 5/2/2025   |   Inventor(s): Nigel Greig, Weiming Luo, David Tweedie, Michael Scerba, Daniela Lecca, Shih Chang Hsueh
Keywords(s):  
Category(s): TherapeuticArea > Neurology, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
4-Amino-2-(piperidin-3-yl)isoindoline-1,3-diones as Anti-inflammatory Agents for Systemic Degenerative and Neurodegenerative Disorders
Summary: The National Institute on Aging (NIA) seeks research co-development partners and/or licensees for the pre-clinical and clinical development of the compounds as anti-inflammatory therapeutics for systemic degenerative and neurodegenerative disorders. Description of Technology: The immunomodulatory imide drugs (IMiDs) thalidomide and its close...
Published: 5/2/2025   |   Inventor(s): Nigel Greig, Michael Scerba, David Tweedie
Keywords(s):  
Category(s): TherapeuticArea > Geriatrics, TherapeuticArea > Neurology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Therapeutics for Neurodegenerative Disorders and Cancer Using Lenalidomide Analogs
Abstract: Inflammatory processes associated with the over-production of tumor necrosis-alpha (TNF-alpha), a potent activator of the immune system accompany numerous neurodegenerative diseases. TNF-alpha has been validated as a drug target with the development of the inhibitors Enbrel and Remicade (fusion antibodies) as prescription medications. Both,...
Published: 4/22/2025   |   Inventor(s): Nigel Greig, Weiming Luo, David Tweedie, Harold Holloway, Qian-sheng Yu, Edward Goetzl
Keywords(s): CNS, Holloway, Immunomodulatory Agents, Inflammation, Lenalidomide, National Institute on Aging, Neurodegenerative Disorders, NIA, THALIDOMIDE, TNF-alpha, Tumor Necrosis-alpha
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Thalidomide Analogs that Inhibit Inflammation and Angiogenesis
Abstract: Thalidomide and its close analogs (lenalidomide and pomalidomide) are widely used to treat a variety of diseases, such as multiple myeloma and other cancers as well as the symptoms of several inflammatory disorders. However, thalidomide is known for its teratogenic adverse effects when first clinically introduced in the 1950s, and is associated...
Published: 4/22/2025   |   Inventor(s): Nigel Greig, Weiming Luo, David Tweedie, Nell Vargesson, Shaunna Beedle, William Figg
Keywords(s): anti-angiogenesis, ANTI-INFLAMMATORY, Lenalidomide, Pomalidomide, THALIDOMIDE
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics