Search Results - chengyu+liu

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Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)
­Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...
Published: 9/12/2024   |   Inventor(s): Jianfeng Cai, Heng Liu
Keywords(s): Alzheimer's Disease, Biotechnology, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 6/5/2024   |   Inventor(s): Li Liu, Jingmin Shu
Keywords(s):  
Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices
Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
­Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023   |   Inventor(s): Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
Keywords(s): Drug Discovery, Infectious Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING Researchers at Stanford have developed a wearable patch that allows for continuous mental health monitoring via electroencephalogram (EEG) recording. EEG technology was developed during the advent of neuroscience nearly a century and a half ago. EEG technology...
Published: 8/17/2023   |   Inventor(s): Ada Poon, Cheng Chen, Joonseok Yang, Hui Wang
Keywords(s): EEG, Neurology, Wearable
Category(s): Technology Classifications > Engineering
Novel Anti-HIV Compounds Using Peptides or Peptide Mimetics
Abstract: The subject invention describes a new class of compounds (such as peptides or mimetics) that target viral RNAs and inhibit the viral life cycle by blocking the viral recognition process. More specifically, these compounds are the first against an RNA Target - currently there are no clinical drugs against RNA targets in the treatment of any...
Published: 4/8/2024   |   Inventor(s): Yun-Xing Wang, Liu Yu, Ping Yu, Ina O'Carroll
Keywords(s): Anti-Viral, HIV
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Use of Anti-CD47 Antibodies for the Treatment of Cancer
Abstract: High expression of CD47, a cell surface receptor on several types of cancer cells, has been identified as a ‘don’t eat me signal’ that inhibits their killing by macrophages or NK cells. Conversely, the CD47 antibody B6H12 that blocks SIRPα binding enhances macrophage-dependent clearance of tumors in several mouse models, although others have...
Published: 4/8/2024   |   Inventor(s): David Roberts, Sukhbir Kaur, Chengyu Liu
Keywords(s): CD47, Stem Cell
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Method and Device for Selectively Labeling RNA
Abstract: Current methods of labeling and synthesizing RNA do not allow for multiple labels or long RNA segments to be synthesized for large RNA on a milligram scale. Investigators at the NCI Structure Biophysics Lab and UT Health Science Center have developed a method to selectively label RNA at specific residues and/or segments using a hybrid solid-liquid...
Published: 4/8/2024   |   Inventor(s): Yun-Xing Wang, Liu Yu, Rui Sousa
Keywords(s): crystallography, Fluorophore labeling, FRET, Isotope labeling, Labeling sensor, NMR Spectroscopy
Category(s): Application > Diagnostics, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Thermal Drift Calibration of Whispering Gallery Mode Microcavities using Optical Frequency Domain Reflectometry
This technology utilizes optical frequency domain reflectometry (OFDR) to collect high resolution temperature measurements in biochemical applications. More specifically, accuracy of measurements is increased in the spatial domain via the OFDR technology being studied in conjunction with whispering gallery mode biochemical sensing. While temperature...
Published: 6/6/2024   |   Inventor(s): Tsu-Te Su, Cheng Li
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Telecommunications > Electro-Optic Devices
Real-Time RT-PCR Assay for the Rapid Detection of Rabies and Other Lyssaviruses
Rabies occurs in more than 150 countries and territories, resulting in at least 55,000 human deaths per year worldwide according to World Health Organization estimates. Rabies is a vaccine-preventable viral disease caused by numerous lyssaviruses that are found in a variety of animal species throughout the world. Rabies virus infects the central nervous...
Published: 7/25/2024   |   Inventor(s): Yu Li
Keywords(s): assay, DA4XXX, DDXXXX, Diagnostics, LYSSAVIRUSES, Modified, NCEZID, NCEZID-DHCPP, Non-rabies, Probe, rabies, REAL-TIME, RT-PCR, VLXXXX, VOXXXX, WBXXXX, WGXXXX, WHXXXX, WIXXXX, XEXXXX, YBXXXX, YGXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, Application > Research Materials, Application > Diagnostics
Universal Diagnostic Assay for Detection and Identification of Poxviruses in Clinical Samples
CDC researchers have developed an assay for detection and diagnosis of poxviruses within clinical samples or from lab culture-systems. The assay specifically targets chordopoxviruses (except avipoxviruses) for PCR-based identification; an improvement upon the current standard of cell culturing methodologies. Individual chordopoxvirus species can cause...
Published: 7/25/2024   |   Inventor(s): Inger Damon, Hui Zhao, Yu Li
Keywords(s): ASSAYS, CDC Docket Import, CDC Docket Import CDC Prosecuting, CHORDOPOXVIRUSES, DA4BXX, DA4XXX, DAXXXX, diagnostic, DXXXXX, OID-NCEZID-DHCPP, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Diagnostics, Application > Research Materials
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