Search Results - hanwen+zhang

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Electronic Fringe Scanning for the Improvement of Medical Imaging Technology
This technology includes an electronic method for fringe scanning in grating-based phase-contrast imaging, which enhances x-ray phase-contrast imaging. Traditional methods use high-density gratings and require fine grating fringes, finer than the detector's resolution, necessitating fringe scanning to obtain phase-contrast information. This process...
Published: 8/12/2024   |   Inventor(s): Han Wen
Keywords(s):  
Category(s): Application > Medical Devices, Collaboration Sought > Licensing, ResearchProducts > Research Equipment
Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery
Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells. Problem: In recent times, the delivery of mRNA has become a major focus for therapeutics. Intracellular delivery is the major challenge. Intracellular delivery requires ionizable lipids for mRNA delivery. In addition to this, these constituents...
Published: 2/6/2024   |   Inventor(s): Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang
Keywords(s): Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Hybrid Computer Tomography Scanning System
The invention relates to a combination hybrid computer tomography (CT) system that is particularly suited for elucidating stages in pulmonary diseases, notably cystic fibrosis and lung cancer. Improved visualization of lung parenchyma and the margins of lung cysts (non-invasive “virtual biopsy”) may provide sufficient detail to distinguish the types...
Published: 10/28/2024   |   Inventor(s): Han Wen
Keywords(s): AA3B6X, AA3CXX, CT, HYBRID, lung cancer, Lung Disease, Lung-Targeted, Pulmonary, PULMONARY FIBROSIS, WBXXXX, XFXXXX, X-RAY, YAXXXX
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Medical Devices, Application > Non-Medical Devices, Application > Software / Apps
A Novel X-ray Grating to Enhance Phase Contrast Imaging
The present invention relates to improving x-ray phase contrast imaging. The invention discloses a novel grating interferometer for phase contrast imaging with hard x-rays that overcomes limitations in the level of sensitivity by utilizing the advantages of far-field interferometers. The novel design and fabrication process can easily acquire absolute...
Published: 10/28/2024   |   Inventor(s): Han Wen
Keywords(s): AA3XXX, Balanced, GRATING, INTERFEROMETER, Two-arm, VCXXXX, VDXXXX, WBXXXX, WIXXXX, XDXXXX, XFXXXX, X-RAY, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Software / Apps, Application > Medical Devices, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Oncology
A Novel Demodulation System in X-ray Imaging
In various x-ray imaging methods, including scattering correction and phase contrast imaging, intensity modulation in space is introduced into the projection images by the use of masks, gratings, or apertures. The present invention relates to a process to demodulate the modulation. The current demodulation processes are either to remove the modulation...
Published: 10/28/2024   |   Inventor(s): Houxun Miao, Han Wen
Keywords(s): AA3XXX, Demodulation, IMAGING, INTENSITY, Modulation, VCXXXX, VDXXXX, VEXXXX, VPXXXX, WBXXXX, WIXXXX, XDXXXX, XFXXXX, X-RAY, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Software / Apps, TherapeuticArea > Neurology, Application > Research Materials, Application > Diagnostics, Application > Medical Devices
Multilayer X-Ray Transmission Grating Array for Phase-Contrast Imaging and Tomography
Classical X-ray Computed Tomography (CT) and radiography are based on X-ray absorption and cannot show soft tissue structures as well as Magnetic Resonance Imaging (MRI). Detecting the phase delay/advance of X-rays that travel through the body could enhance soft tissue contrast 10 - 100 times. Submicron-period X-ray transmission gratings for medical...
Published: 4/8/2024   |   Inventor(s): Han Wen
Keywords(s): AA3XXX, AAXXXX, ARRAY, AXXXXX, GRATING, IMAGING, MICRO, Multilayer-coated, PHASE, SENSITIVE, X-RAY
Category(s): Collaboration Sought > Collaboration
Fluorescent Nanodiamonds as Fiducial Markers for Microscopy
The invention relates to fluorescent nanodiamonds (FNDs) and their uses as fiducial markers for microscopy. FNDs are bright fluorescent probes that do not blink or bleach and have broad fluorescence excitation and emission peaks. The fluorescence intensity can be readily controlled by the size of the FND, the number of fluorescent centers produced...
Published: 4/8/2024   |   Inventor(s): Han Wen, Jennifer Hong, Chang Yi, Ambika Bumb, Susanta Sarkar, Lawrence Samelson, Asit Manna, Keir Neuman
Keywords(s): AC2XXX, AC3XXX, AC4XXX, FIDUCIAL, Fluorescence, fluorescent, IMAGING, MICROSCOPY, Nanodiamonds, nanotechnology, PXXXXX, WIXXXX, XFXXXX, XGXXXX, XHXXXX, YBXXXX
Category(s): Collaboration Sought > Collaboration, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products, Application > Software / Apps, ResearchProducts > Research Equipment, Application > Medical Devices, Application > Research Materials, Application > Diagnostics
Rapid Motion Perception MRI Navigator Method
Available for licensing and commercial development is a non-breathhold flow sensitive navigator technique for reducing respiratory motion artifacts in magnetic resonance (MR) images. The method, called Rapid Motion Perception (RaMP), tracks bulk translational motion of the heart in real-time. The position of the blood volume is a direct representation...
Published: 10/28/2024   |   Inventor(s): Vinay Pai, Han Wen
Keywords(s): AA3AXX, AA3B1X, AA3BXX, AA3XXX, AAXXXX, AXXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Mapping Internal and Bulk Motion of an Object with Phase Labeling in Magnetic Resonance Imaging
Current MRI methods for tracking the motion of an object over a relatively long period of time requires the use of precisely defined grid points that may be inexact because of limited image resolution or the size of the element being tracked. Phase contrast velocity mapping generally provides high spatial resolution and simple data processing. However,...
Published: 10/28/2024   |   Inventor(s): Anthony Aletras, Han Wen
Keywords(s): AA3AXX, AA3B1X, AA3BXX, AA3XXX, AAXXXX, AXXXXX
Category(s): Collaboration Sought > Licensing
Ultrasound-Hall Effect Imaging System And Method
The invention provides for a novel ultrasound-based imaging modality that is based on the interaction of a static magnetic field and conductive moieties in the imaged sample under electrical excitation. The invention also provides a novel ultrasound-based imaging modality that provides a contrast mechanism which reflects the conductivity distribution...
Published: 4/8/2024   |   Inventor(s): Han Wen
Keywords(s): AA3B4X, AA3BXX, AA3XXX, AAXXXX, AXXXXX
Category(s): Collaboration Sought > Licensing
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