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Novel Antifungal Agents with Dual Mechanism of Action
With a clear and growing unmet need, a novel mechanism of action, and demonstrated in vitro superiority over current standard-of-care agents, these novel boron-based antifungal agents represent a compelling early-stage opportunity with significant commercial and public health relevance. Background: Invasive fungal infections caused by opportunistic...
Published: 7/24/2026   |   Updated: 7/24/2026   |   Inventor(s): Bhaskar Das, Joshua Nosanchuk, Daniel Miranda
Keywords(s): Chemistry, Featured, Healthcare, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
Novel Small Molecule Anabolic Agents for Osteoporosis
-Analogs of a naturally occurring phytoestrogen that hold promise for the treatment of osteoporosis and other conditions impacting peri- and post-menopausal women. Background: Menopause significantly speeds bone loss and increases the risk of osteoporosis, a condition characterized by decreased bone mineral density and which impacts more than 200M...
Published: 7/24/2026   |   Updated: 7/7/2026   |   Inventor(s): Bhaskar Das, Hiranmoy Das
Keywords(s): Featured, Pharmaceutical, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
Novel Small Molecule Agents for Glioblastoma
Brain-penetrant small molecule agents possessing a dual targeting mechanism of action (LonP1 and CT-L proteasome inhibition) that may overcome resistance mechanisms that currently plague standard of care treatments for brain tumors such as glioblastoma. Background: Malignant astrocytomas, including glioblastoma (GBM), represent highly aggressive intracranial...
Published: 7/10/2026   |   Updated: 7/6/2026   |   Inventor(s): Bhaskar Das, Daniela Bota
Keywords(s): Chemistry, Nanotechnology, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
Transcription Factors in B cells as Targets for Therapeutic Modulation in SLE
This technology introduces a novel therapeutic approach for systemic lupus erythematosus (SLE) by modulating specific transcription factors in B cells to restore immune tolerance and prevent autoimmunity. Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of harmful autoantibodies from self-reactive...
Published: 6/29/2026   |   Updated: 6/24/2026   |   Inventor(s): Christopher Roman, Abhimanyu Amarnani
Keywords(s): autoimmune disease, autoimmunity, drug mechanism, gene expression analysis, immune disease, lupus, molecular pharmacology, targeted therapeutic delivery, Technologies
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Therapeutics and Vaccines
A novel SHIP1-selective inhibitor to induce blood cell recovery and stem cell engraftment
A32 is a highly selective small molecule that inhibits the SHIP1 enzyme, boosting blood cell growth factors and potentially improving recovery and immunity after chemotherapy, radiation, or stem cell transplantation, without affecting the related SHIP2 enzyme. Background: Hematopoiesis, the process by which blood cells are formed, is critical for...
Published: 6/29/2026   |   Updated: 6/24/2026   |   Inventor(s): William Kerr, Chiara Pedicone, Denzil Bernard
Keywords(s): bleeding disorders, Blood cell recovery, fungal infection, neutrophils, platelets, stem cell transplants, Technologies
Category(s): Technology Classifications > Therapeutics and Vaccines, Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
Utilize lipid nanoparticle-based CRISPR/Cas9 genome editing to delete the Pfkp gene for the treatment of head and neck cancer
This technology introduces a novel lipid nanoparticle-based CRISPR/Cas9 system designed to target the Pfkp gene for the effective treatment of head and neck cancer. Background: Head and neck cancer continues to pose a significant clinical challenge due to its aggressive nature and poor patient prognosis. A primary contributing factor is the overexpression...
Published: 6/22/2026   |   Updated: 6/21/2026   |   Inventor(s): Yamin Li
Keywords(s): cancer, cancer therapy, lipids, nanoparticle, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics and Vaccines
Lipid nanoparticles for lung-targeted mRNA delivery
This technology is a new lipid nanoparticle system that can safely, specifically, and efficiently deliver mRNA to a patient’s lungs. Background: Therapeutics that deliver mRNA to a patient’s lungs offer significant potential for treating a broad spectrum of lung diseases. However, specifically and efficiently delivering mRNA to lung tissue...
Published: 6/22/2026   |   Updated: 6/21/2026   |   Inventor(s): Yamin Li, David Popoola, Zhi Cao, Yuqin Men
Keywords(s): biomaterials, chemistry, drug delivery, gene therapy, nanoparticle drug delivery, RNA, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Targeting Hypoxia-inducible factor 2alpha in cancer
This technology offers a novel approach for new cancer treatments based on inhibiting HIF2α-related processes. Background: Hypoxia-inducible factor 2α (HIF2α) transcription factor is involved in the adaptation of cancer cells (including clear cell renal cell carcinoma (ccRCC)) to low oxygen conditions (hypoxia). It plays a role...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Dimitra Bourboulia, Mark Woodford, John Chisholm
Keywords(s): cancer, cancer therapy, cell proliferation, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Reduction of Lipid Accumulation Reverses Aging
Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis. Background: Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 6/19/2026   |   Updated: 6/15/2026   |   Inventor(s): Stylianos Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
Small molecule inhibition of SHIP1 induces broad activation of natural killer cells
This technology involves methods to activate natural killer (NK) cells by inhibiting the SHIP1 enzyme, offering new therapeutic approaches to treat cancers and infectious diseases. Background: Natural killer (NK) cells play a vital role in the body's innate immune defense, targeting and eliminating tumor cells and infected cells. However, their...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): William Kerr, Matthew Gumbleton
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
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