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Suppression of Therapeutic Escape in Breast Cancer by BTK Inhibition
This technology offers the potential of new and novel cancer treatments based on various inhibitors of protein tyrosine kinases Background: Genes that regulate extracellular growth, differentiation, and developmental signals are commonly mutated in cancers. Protein tyrosine kinases (PTKs) mediate the reversible process of tyrosine phosphorylation,...
Published: 9/5/2024   |   Inventor(s): Douglas Conklin, Xianhui Wang
Keywords(s): breast cancer, cancer, Technologies, therapeutic targets
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Therapeutics and Vaccines
Immunaeon
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Published: 6/7/2024   |   Inventor(s):  
Keywords(s): Startups
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines
mAbs Inhibit Human RAGE by Blocking Its Binding to Heparan Sulfate
Monoclonal antibodies that block heparan sulfate binding to human RAGE, preventing its activation in disease states to serve as a therapeutic treatment. Background: Receptor for Advanced Glycation End products (RAGE), a widely expressed inflammatory receptor for disease states such as atherosclerosis, cancer, Alzheimer disease, drug-induced liver...
Published: 7/9/2024   |   Inventor(s): Ding Xu, Chih Yean Ong, Miaomiao Li
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines
Codagenix, Inc.
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Published: 3/12/2024   |   Inventor(s): Stony Brook University
Keywords(s): Startups
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biological Materials, Technology Classifications > Drug Delivery, Technology Classifications > Viral Vectors, Campus > Stony Brook University
Nucleic Acids that Encode Sodium Channels
Provides a method for screening compounds for use as anti-arrhythmic agents and other medications using mutant mammalian voltage-gated sodium channel subunit. Background: Mammalian voltage-gated sodium channels are pore-forming membrane proteins responsible for the initiation and propagation of actions in nerve, skeletal muscle, and heart cells. The...
Published: 1/29/2024   |   Inventor(s): Sho-Ya Wang
Keywords(s):  
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Technology Classifications > Drug Delivery
Production of Cyclic Macrocycle Library for Rapid High Throughput Evaluations in Aqueous Medium
Produces cyclic peptide libraries quickly, cheaply, and without the need of purification. Background: Cyclic peptides are a class of molecules with important biological activities that could provide substantial medical benefit. Cyclic peptides are often used to develop therapeutic agents and biochemical tools. Unfortunately, the most common method...
Published: 6/21/2024   |   Inventor(s): Qiang Zhang, Huan Chen
Keywords(s): Technologies
Category(s): Campus > University at Albany, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
Compositions and Methods of Treating a Subject with Taurine and Derivatives Thereof
A method of treating or preventing neurological symptoms of lead poisoning using a therapeutically effective amount of taurine Background: Activities such as burning fossil fuels and manufacturing have caused lead contamination throughout the world. Lead is a developmental neurotoxicant that causes brain damage, with children and adolescents being...
Published: 9/18/2024   |   Inventor(s): Lorenz Neuwirth, Bright Emenike
Keywords(s):  
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines, Campus > SUNY Old Westbury
Compositions and Methods for Increased Circulation Half-Life
Single domain antibody composition that enable half-life extension and increased blood:tissue ratios. Background: While strategies such as PEGylation (PEG, polyethylene glycol), albumin binding, and Fc-fusion have been employed to extend the half-life of biological and pharmaceutical agents, there remains a need for additional strategies that not...
Published: 2/2/2024   |   Inventor(s): Brandon Bordeau, Joseph Balthasar, Toan Nguyen
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines
Antiproliferative Betti Bases and Prodrugs Thereof
Betti base drugs and prodrugs optimized to enhance their antiproliferative activity through inhibition of MDM2, MDMX, p53, E3 ligase and FTH1. Background: Betti bases are a family of small organic molecules composed of phenolic or hydroxyarl benzylic amine derivatives. These molecules have established antiproliferative effects on various cancer cell...
Published: 8/13/2024   |   Inventor(s): Sherry Chemler, Xinjiang Wang, Samuel Galster, Rati Lama
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
Algorithm for Identifying Images of Fluorescently-Labeled Cells
Improves the ability to distinguish multiple fluorophores with overlapping emission spectra in biological images of labeled cells by a factor of two or more. Background: Cells (including normal and tumor cells), tissues, microbial communities, and other biological systems generally consist of multiple interacting components, especially proteins...
Published: 4/26/2024   |   Inventor(s): Alex Valm, Yunlong Feng
Keywords(s): bacterial cells, bacterial infection, bioengineering, biofilm control, bioinformatics, biomarker diagnostics, biomarkers, cancer, cell biology, computational biology, dental, diagnostics, digital image processing, fluorescence, fluorescence spectroscopy, gene expression analysis, image analysis, image processing, machine learning, medical imaging, microbial pathogenesis, personalized medicine, RNA, saliva, scanning microscopy, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Viral Vectors
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