Search Results - technology+classifications+%3e+therapeutics+and+vaccines

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Targeting Hypoxia-inducible factor 2alpha in cancer
This technology offers a novel approach for new cancer treatments based on inhibiting HIF2α-related processes. Background: Hypoxia-inducible factor 2α (HIF2α) transcription factor is involved in the adaptation of cancer cells (including clear cell renal cell carcinoma (ccRCC)) to low oxygen conditions (hypoxia). It plays a role...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Dimitra Bourboulia, Mark Woodford, John Chisholm
Keywords(s): cancer, cancer therapy, cell proliferation, regulation of transcriptional dynamics, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Reduction of Lipid Accumulation Reverses Aging
Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis. Background: Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): Stylianos Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
Small molecule inhibition of SHIP1 induces broad activation of natural killer cells
This technology involves methods to activate natural killer (NK) cells by inhibiting the SHIP1 enzyme, offering new therapeutic approaches to treat cancers and infectious diseases. Background: Natural killer (NK) cells play a vital role in the body's innate immune defense, targeting and eliminating tumor cells and infected cells. However, their...
Published: 6/15/2026   |   Updated: 6/15/2026   |   Inventor(s): William Kerr, Matthew Gumbleton
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Methods and Compositions for Prevention and Mitigation of Radiation-Induced Cardiac Injury Using GLP-1 Receptor Agonists
This technology utilizes glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, to prevent and treat radiation-induced cardiac injury, offering a novel medical approach to protect the heart from damages caused by ionizing radiation. Background: Radiation-induced heart disease (RIHD) is a serious complication arising from exposure...
Published: 6/12/2026   |   Updated: 6/12/2026   |   Inventor(s): Snehalata Pawar, Suresh Veeraperumal
Keywords(s): cardiovascular, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Enhancement of adaptive immune responses by post-inoculation administration of fenretinide (N-(4-hydroxyphenyl)retinamide)
This technology uses fenretinide, a synthetic vitamin A derivative, to boost the body’s adaptive immune response after vaccination or infection, making vaccines more effective, especially for poorly immunogenic agents or immunocompromised individuals, without increasing infection severity. Background: The field of vaccine development and immunotherapy...
Published: 6/1/2026   |   Updated: 5/29/2026   |   Inventor(s): Adam Waickman, Stephen Thomas, David Foster, Herbert Slade
Keywords(s): Technologies, vaccine stability, vaccines
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Bruton's Tyrosine Kinase as Anti-Cancer Drug Target
This technology identifies Bruton's Tyrosine Kinase (BTK) as a novel target in breast cancer therapy and provides methods for treatment and diagnosis by inhibiting a specific BTK variant. Background: Protein tyrosine kinases (PTKs) are essential enzymes involved in cellular communication and regulation, often playing a significant role in cancer...
Published: 5/5/2026   |   Updated: 5/4/2026   |   Inventor(s): Douglas Conklin, Antonis Kourtidis, Cheryl Eifert
Keywords(s): breast cancer, cancer, TAF, Technologies, therapeutic targets
Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany
A layer-by-layer mass spectrometry intensity method for de novo direct sequencing of RNA therapeutics and impurities
3D NGMS-Seq is a mass spectrometry-based technology that accurately sequences all RNA types and impurities in mixed samples, enabling comprehensive analysis of RNA therapeutics for drug development, quality control, and regulatory compliance. Background: The field of RNA-based therapeutics has experienced rapid growth due to the success of mRNA vaccines...
Published: 5/7/2026   |   Updated: 5/4/2026   |   Inventor(s): Shenglong Zhang
Keywords(s): Mass spectrometry imaging, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Bioinformatics, Technology Classifications > Therapeutics and Vaccines
Developing a new mechanism-based method to treat behavioral variant frontotemporal dementia
This technology offers a novel, mechanism-based therapeutic method using oxytocin and specific compounds to treat social-affective deficits in behavioral variant frontotemporal dementia (bvFTD). Background: Behavioral variant frontotemporal dementia (bvFTD) is a prevalent form of dementia characterized by severe social and emotional impairments,...
Published: 3/30/2026   |   Updated: 3/30/2026   |   Inventor(s): Wei-Dong Yao
Keywords(s): dementia, electrophysiology, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
β-Catenin agonists recapitulate the protective effects of genetic stabilization
This technology uses drugs that stabilize β-catenin to boost protective immune cells in the lungs, reducing damage from pulmonary hemorrhage and inflammatory lung diseases by activating a novel immunomodulatory pathway. Background: Pulmonary hemorrhage and other inflammatory lung diseases represent significant clinical challenges due to their...
Published: 4/22/2026   |   Updated: 3/24/2026   |   Inventor(s): Mobin Karimi
Keywords(s): gene coding, gene therapies, gene therapy, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
Harnessing IL15C and NKG2D for Potent and Persistent CAR T Cell Therapy in TNBC
This technology is an advanced CAR T-cell therapy for triple-negative breast cancer that uses engineered T-cells to recognize and kill cancer cells regardless of HLA status and includes a built-in IL-15 signal to boost T-cell survival and effectiveness. Background: Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype of breast...
Published: 3/30/2026   |   Updated: 3/24/2026   |   Inventor(s): Mobin Karimi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
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