Search Results - protein+engineering

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METHODS AND COMPOSITION FOR TARGETED RECEPTOR-MEDIATED PROGRAMMABLE MACROMOLECULE DELIVERY
­METHODS AND COMPOSITION FOR TARGETED RECEPTOR-MEDIATED PROGRAMMABLE MACROMOLECULE DELIVERY Researchers at Stanford have developed a novel method for programmable macromolecule delivery via engineered cells, using trogocytosis. Genome editing technologies have revolutionized the field of personalized medicine. Despite its initial promise, many...
Published: 4/22/2024   |   Inventor(s): Lei Qi, Xinyi Chen, Wendy Fantl
Keywords(s): Fusion Protein, Protein Engineering, Trogocytosis
Category(s): Technology Classifications > Biology
Luminescent Biosensor for Detection of Specific Nucleotide Sequences, Small Molecules, and Proteins at Point-of-Care
A serotonin release assay that requires no special training or expensive equipment, and produces results within hours. Background: Platelet serotonin release assay (SRA) is a widely-used clinical assay for diagnosing heparin-induced thrombocytopenia (HIT), a life-threatening complication of heparin treatment. The current SRA procedure entails sending...
Published: 4/3/2024   |   Inventor(s): Stewart Loh, Harsimranjit Sekhon
Keywords(s): biomarker diagnostics, biosensor, detection, DNA nanoswitches, protein engineering, sensor, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Healthcare, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics and Vaccines
LIGHT CONTROLLED PROXIMITY LABELING WITH LOV-TURBO
LIGHT CONTROLLED PROXIMITY LABELING WITH LOV-TURBO Researchers at Stanford University have developed a new approach for proximity labeling via optogenetic control. Allosteric regulation is common in naturally occurring enzymes in living tissues. However, despite its ability to improve spatial and temporal control, allostery has yet to be used extensively...
Published: 7/6/2023   |   Inventor(s): Joleen Cheah, Alice Ting, Songyi Lee
Keywords(s): Allostery, Enzyme, Optogenetics, Protein Engineering, Proximity Labeling
Category(s): Technology Classifications > Biology
ClpP is a Major Regulator in NO Stressed E Coli
Discovery of ClpP Protein, a Major Regulator in Nitric Oxide Stressed Escherichia coli, for Anti-infective Development Strategies Princeton Docket # 15-3064 Antibiotic resistance has become a public health crisis, while the rate of new antibiotic development declines. A promising solution is antivirulence therapy, which targets host-pathogen interactions,...
Published: 2/14/2024   |   Inventor(s): Mark Brynildsen, Jonathan Robinson
Keywords(s): antibiotics, anti-infectives, biomarker/diagnostic, life science research tools, metabolic engineering, protein engineering
Category(s): Biotechnology/Pharmaceuticals, Chemistry
Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets
Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets Princeton Docket # 14-2972 Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 9/12/2022   |   Inventor(s): Tom Muir, Rob Oslund, Jung-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry