Search Results - alexandra+ros

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Nozzle and Dispenser for Time-Resolved Electron Microscopy Structural Studies
Background In the realm of electron microscopy, there is a burgeoning interest in investigating dynamic processes like protein folding and molecular interactions in real time. However, traditional methods mostly yield static images, which makes it difficult to investigate fast-moving dynamic occurrences. One of the main challenges is that protein samples...
Published: 6/4/2024   |   Inventor(s): Peter Wiktor, Abhik Manna, Petra Fromme, Alexandra Ros
Keywords(s):  
Category(s): Physical Science, Bioanalytical Assays, Chemistries & Devices, Advanced Materials/Nanotechnology
Droplet Injector for Time-Resolved Crystallography with XFELs
Background Protein X-ray crystallography has become one of the most successful structural biology techniques since the first three-dimensional structure of myoglobin, a protein, was revealed. Many important scientific discoveries have been made using X-ray crystallography, including understanding insulin’s mechanism of action, mass production...
Published: 1/19/2024   |   Inventor(s): Alexandra Ros, Diandra Doppler, Mukul Sonker, Ana Egatz-Gomez, Richard Kirian, Sahba Zaare, Abhik Manna, Konstantinos Karpos, Roberto Alvarez
Keywords(s):  
Category(s): Physical Science, Bioanalytical Assays, Chemistries & Devices, Imaging
Laser Capture Microdissection (LCM) Microfluidic Platform for Single-Cell Proteomic Analysis
Single-cell proteomics is an emerging field for proteomic analyses of individual cells. Single-cell genomic analyses have greatly expanded our understanding of cell heterogeneity and disease progression; however, protein identification and quantitative cell-to-cell variation provide a deeper level of understanding of the biological regulators in the...
Published: 6/28/2023   |   Inventor(s): Alexandra Ros, Jorvani Cruz Villarreal, Ana Egatz-Gomez, Todd Sandrin, Paul Coleman
Keywords(s):  
Category(s): Proteomic Assays/Reagents/Tools, Neurodegenerative Disease Technologies, Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices
Modular 3D Printed Devices for Sample Delivery
­Background Microfluidic devices are commonly used in serial crystallography applications. In most serial crystallography experiments, the sample molecules are formed into droplets through electrical stimulation, then injected into a focused beam of electrons or X-rays so their structure can be analyzed. The various components of the experiment...
Published: 2/23/2023   |   Inventor(s): Alexandra Ros, John Spence, Diandra Doppler, Garrett Nelson, Richard Kirian, Reza Nazari, Ana Egatz-Gomez, Mukul Sonker, Mohammad Rabbani
Keywords(s):  
Category(s): Physical Science, Bioanalytical Assays, Chemistries & Devices
Dielectrophoretic Length-Selective Separation of Single-Walled Carbon Nanotubes
­Background Single-walled carbon nanotubes (SWNTs) possess unique physical, optical, and electrical properties with great potential for future nanoscale device applications. Common synthesis procedures yield SWNTs with large length polydispersity and varying chirality. Electrical and optical applications of SWNTs often require specific lengths,...
Published: 8/10/2023   |   Inventor(s): Alexandra Ros, Mohammad Rabbani, Christoph Schmidt
Keywords(s):  
Category(s): Physical Science, Advanced Materials/Nanotechnology, Semiconductors, Materials & Processes
Scalable Method for Continuous Synthesis of Upconverting Nanoparticles
Background Upconverting nanoparticles (UCNPs) are materials that absorb infrared light and emit in the ultraviolet-visible-near infrared (UV-NIR) range. Thus, there is a large Stokes shift between excitation and emission, with no overlap. UCNPs—which typically include a NaYF4 or NaGdF4 matrix doped with other lanthanides—can be used for...
Published: 2/23/2023   |   Inventor(s): Ana Egatz-Gomez, Alexandra Ros
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Imaging, Medical Imaging, Physical Science
3D-Printed Microfluidic Device Featuring Electronically Triggered Droplet Generation and Injection for Serial Crystallography
Background Serial femtosecond crystallography (SFX) with recent advances in X-ray free electron lasers (XFELs) is a revolutionary technique for determining the structure of macromolecules at ambient temperature. It has enabled the study of large membrane protein complexes at atomic resolution and their reaction dynamics, previously considered impossible...
Published: 2/23/2023   |   Inventor(s): Alexandra Ros, Daihyun Kim, Diandra Doppler, Jorvani Cruz Villarreal, Richard Kirian, Reza Nazari, Sahir Gandhi
Keywords(s):  
Category(s): Chemical/Biological Sensors, Bioanalytical Assays, Chemistries & Devices, Physical Science, Manufacturing/Construction/Mechanical
Co-Flow Injection for Serial Crystallography Using a 3D-Printed Hybrid Nozzle/T-Junction Device
Background Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) has enabled crystal structure determination of reaction intermediates at ambient temperatures. Unlike traditional crystallography, where a single crystal is irradiated as it rotates, SFX usually involves the injection of a continuous stream of randomly oriented...
Published: 2/23/2023   |   Inventor(s): Alexandra Ros, Daihyun Kim, Austin Echelmeier, Jorvani Cruz Villarreal, Diandra Doppler, Richard Kirian, Reza Nazari
Keywords(s):  
Category(s): Physical Science, Bioanalytical Assays, Chemistries & Devices, Manufacturing/Construction/Mechanical, Chemical/Biological Sensors
Microfluidic Crystallization Array based on Gradient Mixing
Standard diffusion-based crystallization methods are slow and difficult to quantitate, making them extremely ineffective. Initial materials for crystallization are prohibitively expensive, limiting applications such as serial femtosecond crystallography. Researchers around the world have been working on different micro-/nanobatch techniques to simplify...
Published: 2/23/2023   |   Inventor(s): Alexandra Ros, Bahige Abdallah
Keywords(s): Bio-Technology, Crystallography, Drug Screening, Therapeutics
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Medical Diagnostics/Sensors, Pharmaceuticals, Physical Science, Proteomic Assays/Reagents/Tools