Search Results - barbara+smith

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Device to Hold and Image Cell Culture Flasks and Biodome Technologies
Labware receptacles, such as cell culture flasks or biodomes, are ubiquitous tools in cellular biology research which allow for growing as well as imaging cells. However, many labware receptacles face challenges when trying to image them, such as an inability to lay flat against the stage of a microscope, or to reproducibly place the receptacle in the...
Published: 7/29/2024   |   Inventor(s): Barbara Smith, Ethan Marschall, Jarrett Eshima
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Imaging, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Medical Devices
Diagnostic and Prognostic Biomarkers for ALS
Amyotrophic Lateral Sclerosis (ALS) is a terminal neurodegenerative disease defined by the progressive loss of motor neuron function. Despite intense research efforts, clinical outcomes in ALS patients have remained limited. Because there are no diagnostic or prognostic biomarkers for ALS, patients are classified based on the site of symptom onset,...
Published: 4/18/2024   |   Inventor(s): Jarrett Eshima, Barbara Smith, Chris Plaisier
Keywords(s):  
Category(s): Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Neurodegenerative Disease Technologies
Photoacoustic Microscopy Platform
Optical characterization of cells and tissues is necessary to understanding physiological mechanisms. However, current optical imaging techniques have limited imaging depth, often because of strong optical scattering. Photoacoustic imaging (PAI) is a powerful technique which combines the high contrast of optical imaging with the high spatial resolution...
Published: 1/19/2024   |   Inventor(s): Barbara Smith, Ethan Marschall, Joel Lusk, Christopher Miranda
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Medical Devices
Photoacoustic Cuvette Platform
Cuvettes, used to measure the absorbance of light in spectroscopy, are designed to hold a small volume of liquid sample and are optically transparent to allow light to pass through the sample. They are highly useful in spectrophotometry, fluorescence spectroscopy, UV spectroscopy and photoacoustic spectroscopy. While the optical characteristics of the...
Published: 1/19/2024   |   Inventor(s): Barbara Smith, Ethan Marschall, Christopher Miranda
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Medical Devices, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Applied Technologies
Automated Micropipette Electrode Guidance System
Micropipettes are a common laboratory instrument utilized in many fields ranging from cell manipulation to conductance microscopy and electrophysiology. Current optical micropipettes, including electrodes, are unable to simultaneously emit and collect light, which is needed in some in vivo procedures, particularly those requiring incremental steps of...
Published: 1/19/2024   |   Inventor(s): Ethan Marschall, Barbara Smith
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Medical Devices
Suite of Surgical Tools for Electrophysiology Experiments
Perfusion is utilized in the field of electrophysiology to maintain a tissue sample during whole cell patching or other electrophysiology experiments, particularly when recording the electrical activity of neurons or other cells. Electrophysiology provides a high-resolution recording of the activity of these cells, often to compare healthy and disease...
Published: 1/18/2024   |   Inventor(s): Barbara Smith, Ethan Marschall
Keywords(s):  
Category(s): Medical Devices, Manufacturing/Construction/Mechanical, Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices
Device for Monitoring Biological Volatiles Across Time
-collapse: collapse; } ­Volatile organic compounds (VOC) from different cell sources (cultured, animal or human) provide a wealth of untapped information regarding metabolic processes. They hold great potential for use as biomarkers for early non-invasive monitoring of cancer, infection and organ damage or failure. There are currently no technologies...
Published: 2/23/2023   |   Inventor(s): Barbara Smith, Jarrett Eshima, Joel Lusk, Benjamin Ambrose
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Chemical/Biological Sensors, Medical Devices
Non-contact, All Optical, Photoacoustic Microscopy
Invention Description Photoacoustic microscopy (PAM), the imaging technique that generates acoustic waves caused by thermal expansion due to optical absorption, has been successfully utilized to provide absorption-based contrast at unparalleled depths. Recent advancements in PAM have enabled contrast-free image reconstructions of subcellular components...
Published: 2/23/2023   |   Inventor(s): Christopher Miranda, Barbara Smith
Keywords(s):  
Category(s): Life Science (All LS Techs), Medical Devices, Medical Imaging
Novel Ion Indicator Systems
The activity of neurons has long been studied to characterize and understand neurological activity. Neurological activity is directly related to changes in membrane potential due to ion flux across the neuronal membrane. Imaging of this ion flux can provide insight into neural activity and enable research into function and disorders. Current approaches...
Published: 12/13/2024   |   Inventor(s): Christopher Miranda, Barbara Smith
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Life Science (All LS Techs), Medical Devices, Medical Imaging, Neurodegenerative Disease Technologies
Novel Ion Indicator Systems
The activity of neurons has long been studied to characterize and understand neurological activity. Neurological activity is directly related to changes in membrane potential due to ion flux across the neuronal membrane. Imaging of this ion flux can provide insight into neural activity and enable research into function and disorders. Current approaches...
Published: 2/23/2023   |   Inventor(s): Barbara Smith, Christopher Miranda, Madeleine Howell, Joel Lusk
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Medical Imaging, Life Science (All LS Techs), Medical Devices, Neurodegenerative Disease Technologies
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