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Methods for Enhancing Production of Beneficial Short- and Medium- Chain Fatty Acids by the Gut Microbiome
Short-chain fatty acids (SCFAs) which include acetate (C2), propionate (C3) and butyrate (C4) are important, health-benefiting metabolites, produced when microbes in the human colon ferment polysaccharides and dietary fiber. Medium-chain fatty acids (MCFAs), such as caproate (C6) and caprylate (C8), have also been shown to provide health benefits and...
Published: 2/13/2025
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Inventor(s): Anca Delgado, Rosa Krajmalnik-Brown, Dorsa Daeizadeh
Keywords(s):
Category(s): Life Science (All LS Techs), Microbiome, Neurodegenerative Disease Technologies, Cancer, Cancer Therapeutics
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Simultaneous Quantification of Anions using Ion Chromatography
Issues concerning environmental and human health are often dynamic and multifaceted; requiring more rapid and comprehensive methods for data acquisition to help with formulating a strategic or diagnostic approach. Ion chromatography is a common technique to quantify anions in aqueous matrices. However, quantifying multiple anions for a diverse range...
Published: 2/13/2025
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Inventor(s): Srivatsan Mohana Rangan, Devin Bowes, Rosa Krajmalnik-Brown
Keywords(s): Agriculture and Animal Science, Analytical Methods, Autism (ASD), Bioremediation, Chemical Analysis, Environmental, Service Provider - Environmental
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs)
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Methods to Detect Toxic Chromium (VI) and other Anions
Hexavalent Chromium is used in industrial processes and is a known toxic, mutagenic and carcinogenic pollutant. Widespread contamination and high solubility necessitate a simple method for Cr (VI) determination at parts per billion concentrations. The maximum allowable limit for Cr (VI) in groundwater and drinking water, as set by the World Health Organization,...
Published: 2/13/2025
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Inventor(s): Srivatsan Mohana Rangan, Anca Delgado, Rosa Krajmalnik-Brown
Keywords(s): Analytical Devices, Analytical Methods, Environmental, Ion chromatography, Water quality
Category(s): Environmental, Environmental Remediation/Wastewater Treatment, Life Science (All LS Techs)
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Reducing Obesity in Overweight Humans by Altering their Acetate and Energy Uptake through the Management of their Intestinal Microbial Communities
Obesity is epidemic in the United States, and it is increasingly a problem in much of the developed world. The health care costs associated with obesity and obesity-related diseases are a significant and increasing fraction of total healthcare spending.
Currently, the most effective means to reverse obesity is surgical intervention: gastric bypass...
Published: 3/20/2025
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Inventor(s): Bruce Rittmann, Rosa Krajmalnik-Brown, Husen Zhang, John Dibaise, Michael Crowell
Keywords(s): Bio-Technology, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics
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