Search Results - laimonas+kelbauskas

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Mapping Targets of Antibody Binding
The use of monoclonal antibodies (mAbs) in research, diagnostics and therapeutics is ubiquitous, particularly because of their ability to simultaneously achieve high affinity and specificity. mAbs binding typically involves interactions between it and 5-8 amino acids in a specific spatial arrangement. These interactions at defined positions is what...
Published: 8/13/2024   |   Inventor(s): Neal Woodbury, Laimonas Kelbauskas, Akanksha Singh, Pritha Bisarad
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Computing & Information Technology, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Pharmaceuticals
Glucose, pH, and Oxygen Triple Sensor
Glucose, oxygen, and extracellular pH are important components of human metabolic processes -- many diseases are associated with glucose transport and metabolic disorders including diabetes and cancer. Monitoring glucose and cell metabolism can provide invaluable information for understanding these diseases. There are many assays and sensors for glucose,...
Published: 2/23/2023   |   Inventor(s): Yanqing Tian, Liqiang Zhang, Fengyu Su, Deirdre Meldrum, Sean Buizer, Clifford Anderson, Laimonas Kelbauskas, Kristen Lee
Keywords(s): Agriculture and Animal Science, Bio-Technology, Materials and Electronics, Medical Devices and Imaging
Category(s): Advanced Materials/Nanotechnology, Chemical/Biological Sensors, Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Medical Diagnostics/Sensors
Biocompatible gel formulation
Single-cell and cell cluster optical tomography, or Cell-CT, has found increasing application in life sciences basic research. Two limitations to its use in this area are that it can image only fixed cells, and the lack of thixotropic gels that can support live cells and also satisfy refractive index constraints. Researchers at the Biodesign Institute...
Published: 2/23/2023   |   Inventor(s): Roger Johnson, Fengyu Su, Laimonas Kelbauskas, Vivek Nandakumar, Yanqing Tian, Deirdre Meldrum
Keywords(s): Bio-Technology, Drug Screening, Materials, Medical Devices and Imaging, Therapeutics
Category(s): Biomaterials, Life Science (All LS Techs), Medical Imaging
Endoscope for Analyte Consumption Rate Determination with Single Cell Resolution for In Vivo Applications
Determination of consumption/secretion rates of single-cell resolution has great potential for delivering detailed insights into early onset and development of various disease states as well as drug and stimulus response. Due the lack of sensitivity of current technologies, this information is difficult to obtain. Single cell measurements in vivo are...
Published: 2/23/2023   |   Inventor(s): Deirdre Meldrum, Laimonas Kelbauskas, Jeff Houkal, Roger Johnson, Yanqing Tian, Cody Youngbull
Keywords(s): Bio-Technology, Drug Screening, Medical Devices and Imaging, Therapeutics
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Imaging
Single-cell QUantitative In Situ RT-PCR (SQUIRT-PCR)
Quantitative real-time PCR (qRT-PCR) is a well-established method for amplifying DNA using fluorescent probes. Traditionally this is a step-wise process where an aliquot of the DNA to be amplified is deposited in a chamber and amplified/measured in the chamber. Current systems require significant time for sample preparation including tissue disaggregation,...
Published: 2/23/2023   |   Inventor(s): Deirdre Meldrum, Shih-Hui (Joseph) Chao, Thai Tran, Laimonas Kelbauskas, Jeff Houkal, Andrew Hatch, Weimin Gao, David Richardson
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Chips and Fabrication Methods for Rotation of Live Single Cells or Cell Clusters in Live Cell Computed Tomography
High-dimensional single cell visualization technologies are redefining the way we view and understand biological systems, particularly when identifying and analyzing cancer cells. Some cell defects on the surface or in the interior of a cell just can't be properly evaluated in two dimensional microscopy. However, to completely visualize and quantitatively...
Published: 2/23/2023   |   Inventor(s): Hong Wang, Deirdre Meldrum, Rishabh Shetty, Laimonas Kelbauskas, Shih-Hui (Joseph) Chao
Keywords(s): Bio-Technology, Mechanical and Manufacturing, Medical Devices and Imaging
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs)
Chips and Fabrication Methods for Capture and Rotation of Live Single Cells or Cell Clusters
High-dimensional single cell visualization technologies, such as live-cell computed tomography (CT), are redefining the way we view and understand biological systems, particularly when identifying and analyzing cancer cells. Some cell defects on the surface or in the interior of a cell just can't be properly evaluated in two dimensional microscopy....
Published: 2/23/2023   |   Inventor(s): Deirdre Meldrum, Roger Johnson, Iniyan Soundappa Elango, Andrew Shabilla, Hong Wang, Matthew Stanley, Jakrey Myers, Laimonas Kelbauskas, Dean Smith, Pimwadee Limsirichai
Keywords(s): Bio-Technology, Drug Screening, Environmental, Materials and Electronics, Medical Devices and Imaging
Category(s): Life Science (All LS Techs), Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Imaging