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Reconfigurable RF/Digital Hybrid 3D Interconnect

A novel interconnect technology that enables system designers to take better advantage of increased IC power while satisfying energy consumption and space limitations. Background: As the semiconductor industry develops technologies on the nano-scale, interconnect latency is increasing. This places serious limitations on designs, as the input/output...

Published: 4/1/2025 | Inventor(s): Robert Geer, Wei Wang, Tong Jing

Keywords(s): Technologies

Category(s): Campus > SUNY Polytechnic Institute, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Imaging, Technology Classifications > Medical Imaging, Technology Classifications > Optics and Photonics, Technology Classifications > Research Tools and Reagents

Monofunctional MDM2 Degraders for Disease Treatment

This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors. Background: The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...

Published: 3/24/2025 | Inventor(s): Wei Wang, Jennifer Carew, Steffan Nawrocki, Mengyang Chang, Fangchao Bi

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules

Dual-Functional Tetrazine Reagents for Bis-Thiol Bioconjugation and Functionalization

This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific bis-thiol targeting. Background: Bioconjugates are molecules with altered chemical structures via substrates or reagents that allows for biomolecule...

Published: 2/18/2025 | Inventor(s): Wei Wang

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios, Technology Classifications > Research Tools > Reagents

Dual Performing Vinyl-tetrazine for Rapid, Selective Bioconjugation and Functionalization of Cysteine Proteins

This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific single-thiol targeting. This novel method possesses an electron withdrawing tetrazine substituted vinyl moiety that exists as a Michael receptor for...

Published: 2/17/2025 | Inventor(s): Wei Wang

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios, Technology Classifications > Research Tools > Reagents

Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C-H Bonds via H/D Exchange with D2O

This technology presents an organophotocatalytic method for selective deuteration of metabolically labile α-positions in amides, amines, and secondary alcohols. This approach achieves high regioselectivity and deuterium incorporation by masking secondary amines as carbamates and employing a photoredox-HAT (hydrogen atom transfer) process. This...

Published: 1/21/2025 | Inventor(s): Wei Wang

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

Quantum device using insulating topological material

Quantum device using insulating topological material Princeton Docket # 24-4093-1 Current quantum electronic devices often rely on conducting materials, which can limit their efficiency and scalability due to energy loss and interference from bulk conducting states. Princeton researchers have made a significant breakthrough in this field by developing...

Published: 2/3/2025 | Inventor(s): M. Zahid Hasan, Md. Shafayat Hossain, Qi Zhang, Zhiwei Wang, Bing Lv, Yugui Yao

Keywords(s):

Category(s): Quantum Computing and Electrical Engineering

Identification Procedure of Room-Temperature Quantum Spin Hall Topological Edge State

Identification Procedure of Room-Temperature Quantum Spin Hall Topological Edge State Princeton Docket # 24-4088 This groundbreaking technology represents the first realization of room temperature topological states, a significant advancement in the field of quantum materials. Topological insulators, known for their insulating bulk and conducting...

Published: 1/16/2025 | Inventor(s): M. Zahid Hasan, Md. Shafayat Hossain, Nana Shumiya, Maksim Litskevich, Zhiwei Wang, Yugui Yao

Keywords(s):

Category(s): Quantum Computing and Electrical Engineering

Applications of Deuterated Aldehydes and Isonitriles

This innovation is a novel method of synthesizing calcium channel blockers, with applications to extend the half-life of heart disease medications. This can be used as building blocks to create new pharmaceuticals or potentially used to expand the lifespan of current medications. It has applications to site specific calcium-channel blocking that can...

Published: 6/7/2024 | Inventor(s): Christopher Hulme, Wei Wang, Kevin Schofield, Yueteng Zhang

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular

New Deuterated Amino Acid Derivatives

Compositions and methods of making involve the use of alternative acids as reactants instead of carboxylic acids, which produce deuterated amino acids, while carboxylic acids can only synthesize alkyl amino acids. Introducing deuterium to amino acids and derivatives improves biologically active compounds and therapeutics. Modification improves properties...

Published: 6/6/2024 | Inventor(s): Wei Wang, Yue Dong

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Materials > Biomaterials, Technology Classifications > Life Sciences

Bioorthogonal Activation of PROTAC Prodrugs

Utilizing proteolysis targeting chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has become a potential therapeutic strategy for cancer. This innovation is an on-demand prodrug strategy called click-release proteolysis targeting chimeras, or “crPROTACs.” The crPROTACs strategy utilizes bioorthogonal chemistry and...

Published: 1/16/2024 | Inventor(s): Wei Wang, Mengyang Chang, Giri Gnawali

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules

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