Search Results - douglas+mcfadden

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Adeno-Associated Virus-Based Serpin Delivery for Use as Anti-Inflammatory Gene Therapy
Recombinant Adeno-Associated Virus (rAAV) Vector Expressing Serine Proteinase Inhibitor 1 for Inhibiting Multiple Targets in the Inflammatory Cascade This recombinant AAV vector encoding a serine proteinase inhibitor (Serp-1) downregulates inflammation by targeting and inhibiting human serine proteinase enzymes. Inflammatory disorders, including lupus,...
Published: 3/28/2025   |   Inventor(s): Alfred Lewin, Alexandra Lucas, Westley Reeves, Douglas McFadden, Cristhian Ildefonso, Sriram Ambadapadi
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics
Serpin-based Polypeptide Compositions for Wound Healing
Wound healing, although complex, is a remarkably organized process involving hemostasis, inflammation, new tissue generation and remodeling. However, when wounds cover a large surface area, become infected, or occur in patients with impaired healing capacity, such as diabetics or the elderly, wound healing can be prolonged and result in chronic ulceration...
Published: 2/13/2025   |   Inventor(s): Alexandra Lucas, Liqiang Zhang, Jordan Yaron, Douglas McFadden
Keywords(s):  
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals