Search Results - jiaming+zhuang

10 Results Sort By:
p300 KO HEK293T Cell Line for Multiple Research Applications
This technology includes p300 KO HEK293T cells using crispr/cas9 mediated gene editing technology to be used for various research applications. We showed that p300 deficient cells have impaired glycolysis and are hypersensitive to glucose depletion-induced cell death. p300 is one of major transcriptional co-activators that regulates gene transcription...
Published: 8/12/2024   |   Inventor(s): Ming Ji, Xiaoling Li
Keywords(s):  
Category(s): Application > Research Materials, ResearchProducts > Human Cell Lines, TherapeuticArea > Neurology
Novel Human Insulin Cα-Peptide as an Antagonist for Islet and Brain Amyloidosis
Abstract: Over 32 million Americans are living with Diabetes and newly diagnosed cases of type 1 and type 2 diabetes is increasing. A defining feature of type 2 diabetes mellitus (T2DM) is the accumulation of islet amyloid polypeptide (IAPP) fibrils in pancreatic islets. Such accumulations form amyloid plaques, referred to as islet amyloidosis. Mounting...
Published: 4/8/2024   |   Inventor(s): Qing Rong Liu, Min Zhu, Pingbo Zhang, Josephine Egan, Luigi Ferrucci
Keywords(s): Alzheimer’s Disease, Amyloidosis, C-peptide, DIABETES, Egan, insulin, Islet Amyloid Polypeptide, Liu, National Institute on Aging, NIA
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Endocrinology
Novel Human Islet Amyloid Polypeptides as Alzheimer’s Disease Biomarkers and Inhibitors of Amyloid Formation
Abstract: Over 34 million Americans are living with diabetes. An estimated 6.5 million Americans are living with Alzheimer’s disease (AD) and type 2 diabetes mellites (T2DM). Amyloidosis due to aggregation of amyloid-β is key pathogenic event in AD, whereas aggregation of mature islet amyloid polypeptide (IAPP37) in human islet leads to β-cell dysfunction....
Published: 5/23/2024   |   Inventor(s): Qing Rong Liu, Min Zhu, Josephine Egan
Keywords(s): Ad, Age-Associated Disease, Alzheimer’s Disease, Amyloidosis, Amyloids, Biomarkers, DIABETES, IAPP, Islet Amyloid Polypeptide Isoforms, Liu, National Institute on Aging, NIA, PEPTIDYL
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Processing Technique for Ceramic- based Energy Conversion and Storage Devices
Due to rising carbon emissions, extreme weather events and other environmental threats, the demand for alternative energy sources is greater than ever. Therefore, businesses and communities are asking for three things: more affordable electricity, more resilient power, and cleaner energy. Fuel cells, electrolysis cells, membrane reactors, and solid-state...
Published: 1/11/2024   |   Inventor(s): Hai Xiao, Jianhua Tong, Fei Peng, Kyle Brinkman, Jincheng Lei, Yuzhe Hong, Hua Huang, Shenglong Mu, Rajendra Bordia
Keywords(s):  
Category(s): Manufacturing
Novel Chemical Reagents for Antibody-Drug Conjugation, Protein Delivery, and Traceless Release
PRODUCT OPPORTUNITIESNovel chemical reagents for antibody-drug conjugation, protein delivery, and traceless releaseAntibody-drug conjugates with reversible linkerNovel chemical reagent-functionalized polymeric delivery vehicles for protein delivery and traceless releasePRODUCT OPPORTUNITIESCOMPETITIVE ADVANTAGESReversible bonding reaction with small...
Published: 8/10/2023   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Keywords(s):  
Category(s): Biotechnology, Life Sciences, Research tools
New Protein Labeling Reagents for Improved Protein Structural Analysis by Mass Spectrometry
PRODUCT OPPORTUNITIESNew protein labeling reagents for improved protein structural analysis by mass spectrometryPRODUCT OPPORTUNITIESCOMPETITIVE ADVANTAGESCapable of reacting with a wider range of surface-exposed amino acid residues in proteins, leading to greater structural coverage as compared with commonly used protein labeling reagents for mass...
Published: 12/23/2019   |   Inventor(s): Richard Vachet, Sankaran Thayumanavan, Bo Zhao, Jiaming Zhuang
Keywords(s):  
Category(s): Chemicals, Life Sciences, Research tools
Novel Polymeric Nanogels for Controlled Intracellular Protein Delivery and Traceless Release
PRODUCT OPPORTUNITIES Nanogel encapsulated protein prodrugs or therapeutics Nanogel encapsulated diagnostic agents Protein encapsulation reagents and kits for intracellular delivery and traceless release PRODUCT OPPORTUNITIES COMPETITIVE ADVANTAGES Broadly applicable protein encapsulation and delivery technology (capable of encapsulating...
Published: 10/3/2023   |   Inventor(s): Sankaran Thayumanavan, Jiaming Zhuang
Keywords(s):  
Category(s): Life Sciences, Biotechnology, Healthcare, Research tools, Therapeutics & prevention, Nanotechnology, Diagnostic technology
Automated Pain Detection in Pediatric Care
uot;Times New Roman",serif; font-size:12pt">Unmet Need: Continuous pain assessment in infants Continuing advances in intensive care have made it possible for premature infants to survive outside the uterus in Neonatal Intensive Care Unit (NICU) even at very early stages of development. Infants in the NICU may receive an estimated 10-14 painful...
Published: 6/27/2022   |   Inventor(s): Subhanshu Gupta, Huan Hu, Martin Schiavenato
Keywords(s):  
Category(s): Technologies > Health & Well-being > Health-IT, Technologies > Health & Well-being > Medical Devices, Technologies > Energy & Environment > Computer Hardware/Software, Technologies > Energy & Environment > Electrical/Electronics
Bi-Functional RGD Peptide and a Co-Signaling Mechanism to Promote Therapeutic Angiogenesis
Bi-Functional RGD Peptide to Promote Therapeutic Angiogenesis, Treat Ischemic Diseases Technology: While previous studies have focused on the identification of biological ligands to improve the functions of endothelial cells, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide functionalized...
Published: 3/23/2023   |   Inventor(s): Chung-Jen (James) Chou, Ying Mei, Jia Jia
Keywords(s):  
Category(s): BioPharma
Sweat Biomarkers as an Indication of Physiological Conditions
Inventors at the University of Arizona have devised a means by which cortisol isomer ratios in human sweat can be measured and used to evaluate the physiological or psychological state of the patient. Certain cortisol isomer ratios are associated with particular conditions or disorders (high blood pressure, sleep disruption, and others). Other ratios...
Published: 11/16/2023   |   Inventor(s): Esther Sternberg, Min Jia
Keywords(s):  
Category(s): Technology Classifications > Research Tools, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Medical Devices > Diagnostic