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Fusion protein technology for site‑specific integration of RNA into DNA genomes
The technology integrates target RNA into DNA genomes by adding short DNA tails to RNA. Direct RNA integration into CRISPR arrays eliminates the use of harsh transfection methods that fragment DNA sequences.
Background
The development of CRISPR-Cas systems, which are widely used for precise genetic modifications, has advanced the field of genome...
Published: 7/25/2024
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Inventor(s): Alan Lambowitz, Georg Mohr
Keywords(s):
Category(s): Life sciences, Life sciences > Therapeutics > Gene editing
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An integrated sensing chip for attomolar label-free detection of amplified nucleic acids
Summary:
Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification technique and has been widely used for detection of pathogens in many organisms. Current LAMP-based sensors usually require the LAMP products to be labeled in order for them to be detected.
Description:
This new LAMP chip offers a new portable platform to detect...
Published: 7/2/2024
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Inventor(s):
Keywords(s):
Category(s): Agriculture, Engineering & Physical Sciences, Sensors & Controls, Research Tools & Design Tools, Medical Devices, Veterinary Medicine, Life Sciences, Healthcare
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Artificial Reproduction Technique
PRODUCT OPPORTUNITIES
• Novel method to treat sperm for artificial reproduction
• Artificial reproductive kit
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
• Improve functionality and/or fertility of sperm
• Reduces the number of sperm needed for insemination
•...
Published: 11/29/2024
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Inventor(s): Pablo Visconti, Felipe Navarrete
Keywords(s):
Category(s): Biotechnology, Life Sciences, Veterinary science
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Stretchable hybrid response pressure sensor
Background
Electronic skins, e-skins for short, is innovative soft electronics technology that gives robots and devices tactile sensing capabilities like human touch and feel. Robots equipped with human touch sensitivity could be deployed in many different applications ranging from manufacturing and food handling/preparation to medical care and surgery,...
Published: 6/28/2024
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Inventor(s): Nanshu Lu, Kyoung-Ho Ha
Keywords(s):
Category(s): Life sciences > Medical technology, Life sciences, Life sciences > Biomaterials, Computer software > Digital health, Computer software > Robotics
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Magnetohydrodynamic clearing and antibody staining
PRODUCT OPPORTUNITIES
Devices and methods for moving charged molecules into and out of tissue samples
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
Significantly reduces the time required to clear tissue samples
Significantly reduces the time required for histological procedures in large tissue samples
Removes biomarkers...
Published: 11/29/2024
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Inventor(s): Joseph Bergan, Joseph Dwyer
Keywords(s):
Category(s): Biotechnology, Devices, Life Sciences, Research tools
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Let-7 promotes superior anti-tumor activity of CD8 T cells and memory formation
PRODUCT OPPORTUNITIES
Improve T-cell therapies
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
Improve cancer immunotherapies that are based on adoptive T cell transfer/ improves T-cell therapies
TECHNOLOGY DESCRIPTION
This invention demonstrates that let-7 miRNA regulates T cell responses...
Published: 4/4/2025
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Inventor(s): Leonid Pobezinsky, Elena Pobezinskaya
Keywords(s):
Category(s): Biotechnology, Life Sciences, Therapeutics & prevention, Research tools
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Flow Sensor Based on Coulometric Interrogation of a Graphene Microelectrode
PRODUCT OPPORTUNITIES
•Self-powered, high-performance biofluid-flow interrogation devices (e.g., minimally-invasive implantable blood flow monitor, miniaturized flow sensor, transparent flow sensor)
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
•Significantly improved sensitivity (two-orders-of-magnitude improvement)...
Published: 12/3/2024
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Inventor(s): Jinglei Ping, Xiaoyu Zhang
Keywords(s):
Category(s): Devices & sensors, Engineering, Healthcare, Life Sciences, Research tools, Electronics
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Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting
PRODUCT OPPORTUNITIES
Safe and efficacious delivery of payload to a tumor
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
Provides possibility to deliver potentially toxic therapy/molecule to bacteria-associated tumors with significantly reduced off-target accumulation while increasing tumor localization, efficacy,...
Published: 3/1/2024
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Inventor(s): Neil Forbes, Nele Van Dessel, John Klier, Shane Taylor, Vishnu Raman
Keywords(s):
Category(s): Biotechnology, Healthcare, Life Sciences, Therapeutics & prevention
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Wireless e-tattoo for ambulatory monitoring of cardiovascular health
Background
Cardiovascular diseases (CVD) are the leading cause of death in the United States and the world, with hundreds of billions of dollars spent on treating CVD. Heart diseases kill 700,000 people in the United States and nearly four million in the world every year. Early-stage discovery of CVD is critical to treatment preventing fatalities and...
Published: 2/12/2024
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Inventor(s): Nanshu Lu, Sarnab Bhattacharya, Philip Tan, Pulin Wang, Francesca Santucci
Keywords(s):
Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Diagnostic, Life sciences
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Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
PRODUCT OPPORTUNITIES
Noncationic nucleic acid-polymer complexes for nucleic acid delivery
Nucleic acid-polymer complexation kits for nucleic acid encapsulation and intracellular delivery
Novel polymers for nucleic acid delivery with substantially reduced cytotoxicity
PRODUCT OPPORTUNITIES
COMPETITIVE ADVANTAGES
An efficient nucleic...
Published: 11/29/2024
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Inventor(s): Sankaran Thayumanavan
Keywords(s):
Category(s): Biotechnology, Healthcare, Nanotechnology, Life Sciences, Therapeutics & prevention
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