New Protein Labeling Reagents for Improved Protein Structural Analysis by Mass Spectrometry

PRODUCT OPPORTUNITIES

• New protein labeling reagents for improved protein structural analysis by mass spectrometry

PRODUCT OPPORTUNITIES

COMPETITIVE ADVANTAGES

• Capable of reacting with a wider range of surface-exposed amino acid residues in proteins, leading to greater structural coverage as compared with commonly used protein labeling reagents for mass spectrometric analysis.
• Higher sensitivity of comparative protein structural characterization
• Tunable reactivity by incorporating desired functional groups

TECHNOLOGY DESCRIPTION

This invention provides new chemical reagents that can react with a wide range of amino acid residues on proteins, allowing improved comparative protein structural analysis by mass spectrometry.

ABOUT THE INVENTOR

Dr. Vachet is a Professor in the Department of Chemistry at UMass Amherst. His reserach group focuses on developing measurement tools to help optimize drug delivery and to assess the effectiveness of the delivered therapeutics.

AVAILABILITY:

Available for Licensing and/or Sponsored Research

DOCKET:

UMA 18-055

PATENT STATUS:

Patent Pending

NON-CONFIDENTIAL INVENTION DISCLOSURE

LEAD INVENTOR:

Richard Vachet, Ph.D.

CONTACT:

This invention provides new chemical reagents that can react with a wide range of amino acid residues on proteins, allowing improved comparative protein structural analysis by mass spectrometry.