Search Results - amyloidosis

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Cross-linkable matrix-free nanocomposites with tunable optoelectronic functionalities and the methods for their macro-, micro- or nano-structures construction
RPI ID: 2014-054-402 Innovation Summary: Introduces solid-state, matrix-free polymer nanocomposites built entirely from polymer-brush–grafted nanoparticles without a separate bulk polymer matrix. A multimodal (bi- or polydisperse) brush design places dense short chains near the nanoparticle surface for strong steric shielding while...
Published: 3/10/2026   |   Inventor(s): Charles Goodwin, Robert, Jr. Karlicek, Ying Li, Linda Schadler Feist, CHAITANYA ULLAL
Keywords(s): Amyloid Fibrils, Amyloidosis, Biomedical Engineering, Diagnostics, Measurement, Medical Device\Diagnostic Systems, Proteins, SEM1/SEM2, serum amyloid A, SEVI, Staining
Category(s): Biotechnology and the Life Sciences
Novel Human Insulin Cα-Peptide as an Antagonist for Islet and Brain Amyloidosis
Abstract: Over 32 million Americans are living with Diabetes and newly diagnosed cases of type 1 and type 2 diabetes is increasing. A defining feature of type 2 diabetes mellitus (T2DM) is the accumulation of islet amyloid polypeptide (IAPP) fibrils in pancreatic islets. Such accumulations form amyloid plaques, referred to as islet amyloidosis. Mounting...
Published: 4/22/2025   |   Inventor(s): Qing Rong Liu, Min Zhu, Pingbo Zhang, Josephine Egan, Luigi Ferrucci
Keywords(s): Alzheimer’s Disease, Amyloidosis, C-peptide, DIABETES, Egan, insulin, Islet Amyloid Polypeptide, Liu, National Institute on Aging, NIA
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Endocrinology
Novel Human Islet Amyloid Polypeptides as Alzheimer’s Disease Biomarkers and Inhibitors of Amyloid Formation
Abstract: Over 34 million Americans are living with diabetes. An estimated 6.5 million Americans are living with Alzheimer’s disease (AD) and type 2 diabetes mellites (T2DM). Amyloidosis due to aggregation of amyloid-β is key pathogenic event in AD, whereas aggregation of mature islet amyloid polypeptide (IAPP37) in human islet leads to β-cell dysfunction....
Published: 4/22/2025   |   Inventor(s): Qing Rong Liu, Min Zhu, Josephine Egan
Keywords(s): Ad, Age-Associated Disease, Alzheimer’s Disease, Amyloidosis, Amyloids, Biomarkers, DIABETES, IAPP, Islet Amyloid Polypeptide Isoforms, Liu, National Institute on Aging, NIA, PEPTIDYL
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics