Search Results - sankaran+thayumanavan

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Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery
PRODUCT OPPORTUNITIES Noncationic nucleic acid-polymer complexes for nucleic acid delivery Nucleic acid-polymer complexation kits for nucleic acid encapsulation and intracellular delivery Novel polymers for nucleic acid delivery with substantially reduced cytotoxicity PRODUCT OPPORTUNITIES COMPETITIVE ADVANTAGES An efficient nucleic...
Published: 11/29/2024   |   Inventor(s): Sankaran Thayumanavan
Keywords(s):  
Category(s): Biotechnology, Healthcare, Nanotechnology, Life Sciences, Therapeutics & prevention
Polymeric Nanogles for the Encapsulation, Delivery and pH-Triggered Release of Proteins
PRODUCT OPPORTUNITIESNanogel encapsulated protein therapeutics for the treatment of lysosomal storage diseasesNanogel encapsulated diagnostic, imaging or sensing agentsPRODUCT OPPORTUNITIESCOMPETITIVE ADVANTAGESStably encapsulated proteins that are not prone to proteolytic degradation when being delivered to the target siteControlled release of the...
Published: 8/10/2023   |   Inventor(s): Sankaran Thayumanavan, Mijanur Molla, Scott Garman
Keywords(s):  
Category(s): Biotechnology, Diagnostic technology, Healthcare, Life Sciences, Nanotechnology, Research tools
New Protein Labeling Reagents for Improved Protein Structural Analysis by Mass Spectrometry
PRODUCT OPPORTUNITIESNew protein labeling reagents for improved protein structural analysis by mass spectrometryPRODUCT OPPORTUNITIESCOMPETITIVE ADVANTAGESCapable of reacting with a wider range of surface-exposed amino acid residues in proteins, leading to greater structural coverage as compared with commonly used protein labeling reagents for mass...
Published: 12/23/2019   |   Inventor(s): Richard Vachet, Sankaran Thayumanavan, Bo Zhao, Jiaming Zhuang
Keywords(s):  
Category(s): Chemicals, Life Sciences, Research tools
Chance-Constrained Optimization for Treatment of Prostate and Other Cancers in Intensity-Modulated Proton Therapy
The quality of IMPT treatment plans may be drastically diminished by uncertainties such as proton range and patient setup errors. If these uncertainties are not figured into treatment planning, the dose distribution that the patient receives may not be the same as the planned dose distribution. New treatment plans, which include optimized software/programming,...
Published: 7/4/2025   |   Inventor(s): Jianming Liang, Yu An, Wei Liu
Keywords(s):  
Category(s): Computing & Information Technology, Life Science (All LS Techs), Medical Imaging
Enhanced Charge Transport Through Nanoconfinement
A team of accomplished researchers at the University of Massachusetts Amherst has discovered a novel pathway for enhancing anhydrous proton transport in polymeric materials. This pathway entails generating supramolecular nanoscale confinement in polymers containing anhydrous proton transport functionalities. By carefully designing the polymer structures,...
Published: 4/11/2025   |   Inventor(s): Sankaran Thayumanavan, Mark Thomas Tuominen, Ryan Hayward
Keywords(s):  
Category(s): Material science, Nanotechnology, Physical Science, Devices, Clean Energy
Enhanced MALDI-MS Analysis of Peptides Using Amphiphilic Homopolymers
Selective and enhanced detection of peptides from complex mixtures. A special class of polymers is used to selectively extract and concentrate peptides of interest from complex mixtures, while simultaneously enhancing their detection using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.DESCRIPTIONADVANTAGES These polymers can...
Published: 9/26/2025   |   Inventor(s): Sankaran Thayumanavan, Richard Vachet, Elamprakash Nesan Savariar, Marianny Combariza
Keywords(s):  
Category(s): Material science, Research tools, Devices & sensors
Robust Smart Organic Nanoparticles Capable of Encapsulation and Stimuli-Responsive Release of Guest Molecules
TECHNOLOGY DESCRIPTIONThis technology provides a new class of structurally robust smart organic nanoparticles that are formed from covalently linked organic molecules. These organic nanoparticles can be produced in one step from two readily synthesized organic starting materials in the presence of a surfactant. Unlike inorganic nanomaterials such as...
Published: 9/26/2025   |   Inventor(s): Sankaran Thayumanavan, Conghui Yuan
Keywords(s):  
Category(s): Nanotechnology, Devices & sensors, Material science
BIOMARKER-RESPONSIVE DRUG DELIVERY SYSTEMS FOR CONTROLLED RELEASE OF OPIOIDS AND OPIOID ANTAGONISTS
One of the major limitations of opioids, a class of analgesics used for pain management, is their narrow therapeutic range lacking a substantial difference between lethal and therapeutic doses. Opioid-induced toxicity leads to hypoventilation (respiratory depression), resulting in an increased concentration of CO2 and a decreased concentration of O2...
Published: 9/26/2025   |   Inventor(s): Sankaran Thayumanavan
Keywords(s):  
Category(s): Biotechnology, Therapeutics & prevention, Healthcare, Life Sciences