Search Results - gay+crooks

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Regulated Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)
UCLA researchers from the Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026   |   Inventor(s): Gay Crooks, Donald Kohn
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases
Enhancing T Cell Production in Vitro From Stem and Progenitor Cells (UCLA Case No. 2022-257)
UCLA researchers from the Department of Pathology and Laboratory Medicine have developed an innovative differentiation method to increase T cell production for T cell immunotherapy. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026   |   Inventor(s): Gay Crooks, Christopher Seet
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Method for Combined Conditioning and Chemoselection in a Single Cycle (UCLA Case No. 2011-478)
SUMMARY: Researchers at UCLA have developed a highly-efficient technique to engraft and select hematopoietic stem cells directly inside a patient. The invention will improve the fidelity of stem cell transplantations and reduce toxic side effects on patients. BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a mainstay of treatment for...
Published: 12/2/2025   |   Inventor(s): Gay Crooks, Robert Schiestl, Katrin Hacke, Akos Szakmary
Keywords(s): blood cancers, Cancer stem cells, Hematopoietic stem cell transplantation, hematopoietic stem cells, lymphatic cancer, stem cell transplantations, Transplant
Category(s): Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Transplant
2013-741 Bioengineered Thymic Aggregates for Implantation
Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...
Published: 12/2/2025   |   Inventor(s): Gay Crooks, Amelie Montel-Hagen, Brile Chung
Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy
2017-657: Gene Editing Stem Cells for Generating Non-Alloreactive T Cells for Immunotherapy
SUMMARY UCLA researchers in the Department of Pathology and Medicine have developed human stem cells that can be used to generate non-alloreactive, antigen specific T cells for adoptive cell therapy. BACKGROUND Adoptive cell therapy (ACT) with engineered T cells has shown unprecedented potential in the treatment of cancer, infectious diseases,...
Published: 12/2/2025   |   Inventor(s): Gay Crooks, Christopher Seet, Amelie Montel-Hagen
Keywords(s): Gene Editing Systems, Gene Therapy, iPS/stem cells, Life Science Research Tools, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
A Method for Identifying T Cells with Specific Antigen Reactivity (UCLA Case No. 2019-546)
INTRODUCTION: UCLA researchers in the Department of Medicine have developed a novel method for the isolation of T cells reactive to specific antigens for use in cellular immunotherapy. BACKGROUND:T cell responses to proteins on antigen presenting cells is exceptionally antigen-specific. The identification of antigen-specific T cells, or the sequences...
Published: 7/31/2025   |   Inventor(s): Christopher Seet, Gay Crooks
Keywords(s): Autoimmune, Immunotherapy, Infectious Diseases, Life Science Research Tools, Therapeutics & Vaccines
Category(s): Therapeutics > Autoimmune, Therapeutics > Infectious Diseases