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Search Results - huixin+he
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Two Compartment Model for Detecting the Toxicity of Liver Metabolites
Overview Liver toxicity is a significant reason many new drugs fail in clinical trials. Primary human hepatocytes (PHHs) are the current gold standard for in vitro liver models; however, they have a number of limitations. We have invented an easy-to-use two-compartment device that provides in vitro 3D high-throughput prediction for safety assessments...
Published: 5/20/2024
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Inventor(s):
Kim Boekelheide
,
Jeffrey Morgan
,
Blanche Ip
,
Susan Hall
,
Hui Li
Keywords(s):
Category(s):
Diagnostics
Antibody to Mitochondrial Uniporter (MCU
This technology includes a generated polyclonal antibody in rabbit that detects the mitochondrial uniporter (MCU) protein. This antibody was created by immunizing rabbits with a synthesized sequence of the MCU protein and can be used to identify and quantify MCU protein in various tissues. The polyclonal nature of the antibody ensures it recognizes...
Published: 8/12/2024
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Inventor(s):
Toren Finkel
,
Xin Pan
Keywords(s):
Category(s):
Application > Research Materials
,
Collaboration Sought > Licensing
,
Collaboration Sought > Materials Available
,
ResearchProducts > Antibodies
Methods and Systems for Automatically Determining Magnetic Field Inversion Time of a Tissue Species
This technology includes a computer-implemented method for determining magnetic field inversion time of a tissue species using a T1-mapping image, information about the region of interest, and a tissue classification algorithm. This method includes T1-mapping image comprising a plurality of T1 values within an expected range of T1 values for the tissue...
Published: 8/12/2024
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Inventor(s):
Bruce Spottiswoode
,
Xlaoguang Lu
,
Xiaoming Bi
,
Christopher Glielmi
,
Andreas Greiser
,
Hui Xue
,
Peter Kellman
Keywords(s):
Category(s):
Application > Diagnostics
,
Application > Software / Apps
,
Collaboration Sought > Licensing
,
ResearchProducts > Computational models/software
,
TherapeuticArea > Cardiology
Functions and Targets of Therapeutic MicroRNAs to Treat and Diagnose Cancer
This technology includes a method to identify potentially therapeutic microRNAs in cancer, particularly squamous cell carcinoma of the head and neck (HNSCC). This approach first utilizes a large and publicly available expression dataset, which is then validated by a smaller independent dataset to determine deregulated microRNAs expression. These results...
Published: 8/12/2024
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Inventor(s):
Carter Van Waes
,
Anthony Saleh
,
Hui Cheng
,
Zhong Chen
Keywords(s):
Category(s):
Application > Research Materials
,
Application > Therapeutics
,
TherapeuticArea > Oncology
General-purpose Deep Learning Image Denoising Based on Magnetic Resonance Imaging Physics
This technology includes a novel method to train deep learning convolution neural network model to improve the signal-noise-ratio for the magnetic resonance (MR) imaging. The novelty lies on the fact that actual MR imaging physics information is used in the deep learning training. The resulting model achieves significant signal-to-noise ratio (SNR)...
Published: 4/8/2024
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Inventor(s):
Hui Xue
,
Peter Kellman
Keywords(s):
Category(s):
Application > Software / Apps
,
Collaboration Sought > Licensing
,
ResearchProducts > Computational models/software
Phase Sensitive Motion Correction and T1 Mapping for Cardiovascular Magnetic Resonance Imaging
This technology includes a method of correcting the motion during T1 mapping using cardiovascular magnetic resonance imaging (MRI). Ischemic heart disease is the leading cause of death in the United States. The lack of blood supply among myocardial tissue, especially for scar regions, changes the T1 relaxation value of heart muscles. The non-invasive...
Published: 8/12/2024
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Inventor(s):
Peter Kellman
,
Hui Xue
Keywords(s):
Category(s):
Application > Medical Devices
,
Application > Software / Apps
,
Collaboration Sought > Licensing
,
ResearchProducts > Computational models/software
,
TherapeuticArea > Cardiology
Controlling the spatial distribution: A Synthesis of 3D Deterministic Disordered Nanostructure Design, Selection, and Optimization based on their Star Discrepancy
3D nanostructure designs for broadband efficiency improvements are still needed for many applications such as photocatalysis, photovoltaics, optoelectronic devices, and other optical devices. Inventors: Hui Zhao, Shengjie Zhai, Yihong Zhao Collective expertise includes: Micro and nano fluidics, Lab-on-chip technology, nanotechnology and micro/nano...
Published: 4/22/2024
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Inventor(s):
Hui Zhao
,
shengjie zhai
,
Yihong Zhao
Keywords(s):
Category(s):
Computer Science & Software
,
All
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING Researchers at Stanford have developed a wearable patch that allows for continuous mental health monitoring via electroencephalogram (EEG) recording. EEG technology was developed during the advent of neuroscience nearly a century and a half ago. EEG technology...
Published: 8/17/2023
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Inventor(s):
Ada Poon
,
Cheng Chen
,
Joonseok Yang
,
Hui Wang
Keywords(s):
EEG
,
Neurology
,
Wearable
Category(s):
Technology Classifications > Engineering
CD206 Small Molecule Modulators, Their Use and Methods for Preparation
Abstract: Pancreatic ductal adenocarcinoma (PDA) accounts for more than 90% of pancreatic cancer cases, and it is one of the most aggressive malignancies with a 5-year survival rate of 6%. The high mortality rate caused by PDA is primarily from the lack of early diagnosis – it is often asymptomatic in early stages – and a poor response to conventional...
Published: 4/8/2024
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Inventor(s):
Udo Rudloff
,
Juan Marugan
,
Xin Hu
,
Raul Calvo
,
Noel Southall
,
Bolormaa Baljinnyam
Keywords(s):
CD206
,
M1 Macrophage
,
M2 Macrophage
,
Pancreatic Cancer
,
Pancreatic Ductal Adenocarcinoma
,
PDA
,
Rudloff
,
TAM
,
Tumor-Associated Macrophages
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Oncology
,
Collaboration Sought > Collaboration
Fully Human Antibody Targeting Tumor Necrosis Factor Receptor Type 2 (TNFR2) for Cancer Immunotherapy
Abstract: Tumor necrosis factor receptor type 2 (TNFR2)-expressing regulatory T cells (Tregs), present in the tumor microenvironment, play an important role in tumor immune evasion. TNFR2 plays a crucial role in stimulating the activation and proliferation of Tregs, a major checkpoint of antitumor immune responses. In addition to its expression on Tregs,...
Published: 5/22/2024
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Inventor(s):
Joost Oppenheim
,
Dimiter Dimitrov
,
De Yang
,
Xin Chen
,
Zhongyu Zhu
Keywords(s):
ADCC
,
ANTIBODY
,
Antibody-dependent Cellular Cytotoxicity
,
CANCER
,
Immunotherapy
,
Oppenheim
,
TNFR2
,
Tregs
,
Tumor Necrosis Factor Receptor Type 2
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Therapeutics
,
TherapeuticArea > Oncology
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