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Methods and Sequences for mRNA and Other HIV Vaccine Development
Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine. Problem: Despite decades of research, there is currently no vaccine to prevent HIV infection. A major goal of HIV vaccine programs is to generate bNAbs, which...
Published: 3/31/2025   |   Inventor(s): George Shaw, Edward (Ted) Kreider, Beatrice Hahn, Ashwin Skelly, Hui Li, Drew Weissman
Keywords(s): Bioengineering, HIV/AIDS, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Vaccines
CNN Architecture for Disease Identification from Retinal Images
The rise of artificial intelligence is changing the shape of many different fields, and ophthalmic medicine is no exception. Convolutional neural networks (CNNs) have achieved remarkable results in the assisted diagnosis of ophthalmic diseases. However, they face challenges such as limited labeling and small dataset sizes. In recent years, self-supervised...
Published: 3/19/2025   |   Inventor(s): Yalin Wang, Xin Li, Wenhui Zhu, Oana Dumitrascu
Keywords(s): Medical Devices and Imaging, Medical Software
Category(s): Artificial Intelligence/Machine Learning, Computing & Information Technology, Imaging, Life Science (All LS Techs), Medical Imaging
First in class use of the estrogen receptor-b agonist in treating Angelman syndrome and relevant autism spectrum disorders
Overview Angelman syndrome is a genetic disorder caused by UBE3A gene dysfunction, leading to cognitive impairment, motor coordination issues, and developmental delays. Research suggests that oligodendroglial dysfunction, which affects myelination in the brain, contributes to these conditions. Based on the research, this invention discloses a novel...
Published: 3/17/2025   |   Inventor(s): Yu-Wen Huang, Xin Yang
Keywords(s):  
Category(s): Genetic Diseases, Therapeutics, Therapy Targets
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 3/4/2025   |   Inventor(s): Yong Zeng, He Yan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics
Novel Transparent Hole Contact for Bifacial Cd(Se)Te Thin-Film Solar Cells
Background Polycrystalline Cd(Se)Te thin-film solar cells are made of a combination of cadmium (Cd), selenium (Se), and tellurium (Te) elements and exhibit efficient light absorption properties and a tunable bandgap depending on the ratio between the elements. Cd(Se)Te thin-film solar cells currently make up 5% of the global photovoltaic market, and...
Published: 2/28/2025   |   Inventor(s): Yong-Hang Zhang, Xin Qi, Zheng Ju
Keywords(s):  
Category(s): Physical Science, Energy & Power, Advanced Materials/Nanotechnology
HFSIO as Gate Insulator for N-Polar Gan HEMTs (Case No. 2024-268)
Summary: Researchers in the UCLA Department of Electrical and Computer Engineering have developed a new, high-performance transistor for high-frequency and high-power systems. Background: Gallium nitride (GaN) high electron mobility transistors (HEMTs) are critical for high-frequency and high-power electrical applications due to their superior material...
Published: 2/14/2025   |   Inventor(s): Elaheh Ahmadi, Oguz Odabasi, Xin Zhai
Keywords(s): atomic layer deposition, dielectric gates, field-effect transistors (FETs), gallium nitride, GaN, G-polar GAN, hafnium silicon oxide, HfSiO, high dielectric constant materials, high electron mobility transistors, high electron mobility transistors (HEMTs), high frequency electronics, high power electronics, N-polar GAN, organic field effect transistors, quality control manufacturing, scalable manufacturing, solid-state thermal transistor, strength-thermal stability, thermal stability, thermal transistor, Thin-Film Transistor, Transistor, transistors
Category(s): Chemical, Chemical > Chemical Processing & Manufacturing, Electrical, Electrical > Electronics & Semiconductors, Materials, Materials > Semiconducting Materials, Materials > Metals
Enzymatic Reactions for Modifying and Labeling Extracellular Vesicles
Applies Enzymatic Glycan Engineering to Functionalize and Tag Extracellular Vesicles This method for modifying extracellular vesicles combines enzymatic glycan engineering with chemoselective functionalization to unlock applications such as targeted drug delivery. Extracellular vesicles are lipid bilayer-enclosed nanoparticles secreted by cells, acting...
Published: 3/27/2025   |   Inventor(s): Zhongwu Guo, Mohit Jaiswal, Yong Zeng, Xin Zhou, Jiatong Guo
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Human Health Care > Diagnostics
Two Compartment Model for Detecting the Toxicity of Liver Metabolites
Overview Liver toxicity is a significant reason many new drugs fail in clinical trials. Primary human hepatocytes (PHHs) are the current gold standard for in vitro liver models; however, they have a number of limitations. We have invented an easy-to-use two-compartment device that provides in vitro 3D high-throughput prediction for safety assessments...
Published: 3/5/2025   |   Inventor(s): Kim Boekelheide, Jeffrey Morgan, Blanche Ip, Susan Hall, Hui Li
Keywords(s):  
Category(s): Diagnostics
Antibody to Mitochondrial Uniporter (MCU
This technology includes a generated polyclonal antibody in rabbit that detects the mitochondrial uniporter (MCU) protein. This antibody was created by immunizing rabbits with a synthesized sequence of the MCU protein and can be used to identify and quantify MCU protein in various tissues. The polyclonal nature of the antibody ensures it recognizes...
Published: 8/12/2024   |   Inventor(s): Toren Finkel, Xin Pan
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Antibodies
Methods and Systems for Automatically Determining Magnetic Field Inversion Time of a Tissue Species
This technology includes a computer-implemented method for determining magnetic field inversion time of a tissue species using a T1-mapping image, information about the region of interest, and a tissue classification algorithm. This method includes T1-mapping image comprising a plurality of T1 values within an expected range of T1 values for the tissue...
Published: 8/12/2024   |   Inventor(s): Bruce Spottiswoode, Xlaoguang Lu, Xiaoming Bi, Christopher Glielmi, Andreas Greiser, Hui Xue, Peter Kellman
Keywords(s):  
Category(s): Application > Diagnostics, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology
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