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Search Results - zhongwu+guo
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High-Yield Synthesis of Glycosphingolipids
Enables Simple and Efficient Synthesis of Various Glycosphingolipids and their Derivatives for Diagnostic and Biological Applications This strategy enables the diversity-oriented synthesis of various glycosphingolipids (GSLs). GSLs are a family of glycolipids with a sphingoid or a ceramide as the hydrophobic moiety linked to the downstream end of a...
Published: 9/3/2024
|
Inventor(s):
Zhongwu Guo
,
Qingjiang Li
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Diagnostics
,
Technology Classifications > Human Health Care > Therapeutics
Analytical System to Identify Glycolipids and Glycosphingolipids in Tissues
Mass Spectrometry Database and Software Improves Characterization of Complex and Unknown Glycolipids This liquid chromatography, tandem mass spectrometry (LC-MS/MS) system utilizes an extensive mass spectrometry database and a two-step searching procedure to identify glycolipids and glycosphingolipids. Glycolipids play an important role in various...
Published: 6/27/2021
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Inventor(s):
Zhongwu Guo
,
Jinying Zhao
,
Kari Basso
,
Laura Bailey
,
Tianqi Gao
,
Fanran Huang
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Diagnostics
,
Technology Classifications > Research Tools > Biological Materials
(XN) 2005-059 PTEN Null Cell Lines
PTEN Null Cell LinesBACKGROUNDPTEN (phsosphatase and tensin homolog deleted on chromosome 10) is a tumor suppressor gene identified to be frequently mutated/deleted in various human cancers. Besides carcinogenesis, Pten may play important roles in regulating stem cell activity, insulin action and development. PTEN is a member of the protein tyrosine...
Published: 7/19/2023
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Inventor(s):
Hong Wu
,
Daniel Freeman
Keywords(s):
Animal Models
,
Cell Lines
,
Life Science Research Tools
,
Oncology
Category(s):
Life Science Research Tools > Animal Models
,
Life Science Research Tools > Cell Lines
,
Life Science Research Tools
,
Therapeutics > Oncology
2004-073 Murine PTEN Null Prostate Cancer Model
Murine PTEN Null Prostate Cancer ModelBACKGROUNDIn the western world, prostate cancer remains the most common malignancy and the second-leading cause of cancer-related deaths in men. The PTEN gene (phosphotase and tensin homologue deleted on chromosome 10) has been well characterized as a tumor suppressor gene, and its malfunction/deletion has been...
Published: 7/19/2023
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Inventor(s):
Hong Wu
,
Xin Liu
,
Steve Wang
Keywords(s):
Category(s):
Life Science Research Tools
Shape-based analysis of right ventricular dysfunction associated with acute pulmonary embolism
Acute pulmonary embolism (APE) is the third most common cause of death in the US with at least 600,000 cases occurring annually. APE results from migration of emboli to the lungs and obstruction of pulmonary blood vessels. If detected in early stages of development, the high rate of mortality caused by APE may be reduced significantly. A better...
Published: 2/23/2023
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Inventor(s):
Jianming Liang
,
Nima Tajbakhsh
,
Wenzhe Xue
,
Hong Wu
,
Eileen Mcmahon
,
Marek Belohlavek
Keywords(s):
Category(s):
Life Science (All LS Techs)
,
Medical Imaging
Automatic diagnosis of pulmonary embolism by machine learning-based detection of pulmonary trunk
Pulmonary embolism is a common cardiovascular emergency with approximately 600,000 incidents and 200,000 deaths occurring annually in the United States. CT pulmonary angiography (CTPA) has become the reference standard for pulmonary embolism diagnosis, but this technique has several issues with interpretation of the intricate branching structure of...
Published: 2/23/2023
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Inventor(s):
Jianming Liang
,
Hong Wu
,
Kun Deng
Keywords(s):
Bio-Technology
,
Networks, IT, Software and Communication
Category(s):
Life Science (All LS Techs)
,
Medical Imaging
New Immunotherapies for Cancer
Background Wayne State University researchers have developed a novel strategy to fight cancer and eradicate tumors through stimulation of the immune system. Curing cancer via the activation of patients’ immune system is considered an ideal strategy due to the potentially high potency and specificity of the human immune system to eradicate tumors....
Published: 6/16/2023
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Inventor(s):
Zhongwu Guo
,
Qianli Wang
,
Shouchu Tang
Keywords(s):
Cancer Therapies
,
Drug Delivery
,
Pharmaceuticals
,
Therapeutics
,
Vaccines
Category(s):
Therapeutics
,
Life Science
,
Diseases
,
Oncology