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REV-ERBα Modulators for the Treatment of Autoimmune Disorders

Activates the REV-ERBα Nuclear Receptor to Suppress TH17 Cell Development and TH17-Mediated Autoimmune and Chronic Inflammation These small molecules activate the REV-ERBα nuclear receptor to repress TH17 cell activity and treat autoimmune and chronic inflammatory disorders. TH17 cells are a subset of CD4+ T cells that play key roles in...

Published: 3/13/2025 | Inventor(s): Laura Solt, Theodore Kamenecka, Yuanjun He, Brett Bookser, Mike Lizarzaburu

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics

Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay

Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...

Published: 3/4/2025 | Inventor(s): Yong Zeng, He Yan

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics

Silicon-CdTe-Halide Perovskite Triple-Junction Solar Cell

Background Solar energy is one of the most abundant and affordable energies in the world. However, converting solar energy into electricity significantly relies on the power conversion efficiency of the solar cell’s technology. Due to the current limitations of the various materials and physics in the solar cell’s technology, it is a great...

Published: 2/28/2025 | Inventor(s): Feng Yan, Yanfa Yan

Keywords(s):

Category(s): Energy & Power, Advanced Materials/Nanotechnology, Physical Science

Silicon-CdTe-Halide Perovskite Triple-Junction Solar Cell

Published: 2/28/2025 | Inventor(s): Feng Yan, Yanfa Yan

Keywords(s):

Category(s): Energy & Power, Advanced Materials/Nanotechnology, Physical Science

Smart Nanoparticle-Based Cellular Transfection Tool for Therapeutic Development

Utilizes Light-Responsive Nanoparticles to Load Exosomes with Cargo Molecules Precisely and Efficiently, Maximizing Their Ability as Therapeutics This smart nanoparticle-based cellular transfection tool utilizes light-responsive nanoparticles to load therapeutic cargo molecules on demand into extracellular vesicles (EVs), or so-called exosomes, for...

Published: 2/26/2025 | Inventor(s): Mei He

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics

Super-sodiophilic seeds for dendrite‑free sodium metal batteries

Background As the demand for renewable energy sources and electric vehicles grows, there is a pressing need for efficient, sustainable, and cost-effective battery technologies. Sodium-metal batteries (SMBs) show great promise for energy storage applications due to the natural abundance and low cost of sodium compared to lithium. However, SMBs...

Published: 2/11/2025 | Inventor(s): Arumugam Manthiram, Jiarui He, Amruth Bhargav

Keywords(s):

Category(s): Physical sciences > Energy > Battery or electrochemical

A Self-Regenerative Heat Pump (Case No. 2025-042)

Summary: UCLA researchers from the Department of Materials Science and Engineering have developed an innovative device designed to optimize heat transport with improved efficiency and flexibility. Background: Heat transfer technologies play a crucial role in a wide range of applications, from thermoelectric coolers to vapor-compression systems, enabling...

Published: 2/14/2025 | Inventor(s): Qibing Pei, Hanxiang Wu, Yuan Zhu, Wenzhong Yan, Sumanjeet Kaur

Keywords(s): Flexible Electronics, heat control, heat controlling devices, Heat Transfer, joule heating, light-to-heat conversion, Virtual Reality Braille Haptic Technology Joule Heating

Category(s): Materials, Materials > Functional Materials, Electrical, Electrical > Flexible Electronics, Medical Devices, Mechanical, Mechanical > Heat Transfer

Enhanced fluorescence via DNA aptamer optimization

This invention improves the fluorescence of DNA-based aptamers by substituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...

Published: 12/6/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform

Fluorescence lifetime imaging for retinal function assessment

This invention uses a laser-based imaging system to study the eye’s retina. By measuring light responses, it provides insights into retinal health and potential diseases like age-related macular degeneration. Background Two-photon excited fluorescence (TPEF) is a powerful technique used to study the eye. TPEF allows researchers to excite intrinsic...

Published: 10/24/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Trung Nguyen, Yuan-I Chen, H. Grady Rylander, Yu-An Kuo, Soonwoo Hong, Anh-Thu Nguyen, Yujie He

Keywords(s):

Category(s): Life sciences > Imaging, Life sciences > Imaging > Microscopy

Enhanced VR Battery Life through Perception-Guided Color Encoding

Innovative VR display power reduction using color perception technology, which enhances battery life without sacrificing visual quality Institute Reference: 1-24019 Background The rapid advancement of Virtual Reality (VR) and Augmented Reality (AR) technologies has resulted in a growing demand for higher resolution, faster refresh rates, and improved...

Published: 10/22/2024 | Inventor(s): Yuhao Zhu, Abhishek Tyagi, Jiayi He, Budmonde Duinkharjav, Kenneth Chen, Qi Sun, Nisarg Ujjainkar

Keywords(s):

Category(s): Optics, Computer Software, Devices

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