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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Competency Med Assessment Pro
​ Invention Summary: Competency Medical Assessment Pro (MAP) is a real‐time online assessment system developed as an innovative solution designed to streamline the feedback process to medical students, focusing on the 13 Entrustable Professional Activities (EPAs) essential for medical school graduation, as outlined by the AAMC (American Association...
Published: 5/9/2025   |   Inventor(s): Archana Pradhan, Steven Wen, Guangde He, Jie Zhao
Keywords(s):  
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms
REV-ERBα Modulators for the Treatment of Autoimmune Disorders
Activates the REV-ERBα Nuclear Receptor to Suppress TH17 Cell Development and TH17-Mediated Autoimmune and Chronic Inflammation These small molecules activate the REV-ERBα nuclear receptor to repress TH17 cell activity and treat autoimmune and chronic inflammatory disorders. TH17 cells are a subset of CD4+ T cells that play key roles in...
Published: 3/13/2025   |   Inventor(s): Laura Solt, Theodore Kamenecka, Yuanjun He, Brett Bookser, Mike Lizarzaburu
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 3/4/2025   |   Inventor(s): Yong Zeng, He Yan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics
Silicon-CdTe-Halide Perovskite Triple-Junction Solar Cell
Background Solar energy is one of the most abundant and affordable energies in the world. However, converting solar energy into electricity significantly relies on the power conversion efficiency of the solar cell’s technology. Due to the current limitations of the various materials and physics in the solar cell’s technology, it is a great...
Published: 2/28/2025   |   Inventor(s): Feng Yan, Yanfa Yan
Keywords(s):  
Category(s): Energy & Power, Advanced Materials/Nanotechnology, Physical Science
Silicon-CdTe-Halide Perovskite Triple-Junction Solar Cell
Background Solar energy is one of the most abundant and affordable energies in the world. However, converting solar energy into electricity significantly relies on the power conversion efficiency of the solar cell’s technology. Due to the current limitations of the various materials and physics in the solar cell’s technology, it is a great...
Published: 2/28/2025   |   Inventor(s): Feng Yan, Yanfa Yan
Keywords(s):  
Category(s): Energy & Power, Advanced Materials/Nanotechnology, Physical Science
Smart Nanoparticle-Based Cellular Transfection Tool for Therapeutic Development
Utilizes Light-Responsive Nanoparticles to Load Exosomes with Cargo Molecules Precisely and Efficiently, Maximizing Their Ability as Therapeutics This smart nanoparticle-based cellular transfection tool utilizes light-responsive nanoparticles to load therapeutic cargo molecules on demand into extracellular vesicles (EVs), or so-called exosomes, for...
Published: 2/26/2025   |   Inventor(s): Mei He
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Super-sodiophilic seeds for dendrite‑free sodium metal batteries
Background As the demand for renewable energy sources and electric vehicles grows, there is a pressing need for efficient, sustainable, and cost-effective battery tech­nologies. Sodium-metal batteries (SMBs) show great promise for energy storage applications due to the natural abundance and low cost of sodium compared to lithium. However, SMBs...
Published: 2/11/2025   |   Inventor(s): Arumugam Manthiram, Jiarui He, Amruth Bhargav
Keywords(s):  
Category(s): Physical sciences > Energy > Battery or electrochemical
A Self-Regenerative Heat Pump (Case No. 2025-042)
Summary: UCLA researchers from the Department of Materials Science and Engineering have developed an innovative device designed to optimize heat transport with improved efficiency and flexibility. Background: Heat transfer technologies play a crucial role in a wide range of applications, from thermoelectric coolers to vapor-compression systems, enabling...
Published: 2/14/2025   |   Inventor(s): Qibing Pei, Hanxiang Wu, Yuan Zhu, Wenzhong Yan, Sumanjeet Kaur
Keywords(s): Flexible Electronics, heat control, heat controlling devices, Heat Transfer, joule heating, light-to-heat conversion, Virtual Reality Braille Haptic Technology Joule Heating
Category(s): Materials, Materials > Functional Materials, Electrical, Electrical > Flexible Electronics, Medical Devices, Mechanical, Mechanical > Heat Transfer
Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by sub­stituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
Published: 12/6/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
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