Search Results - hcv

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Diagnostic Marker for Improving Treatment Outcomes of Hepatitis C
Abstract: The National Cancer Institute (NCI) Division of Cancer Epidemiology and Genetics (DCEG)  Immunoepidemiology Branch is seeking statements of capability or interest from parties interested in collaborative research to further co-develop a gene-based diagnostic for Hepatitis C virus (HepC, HCV). NCI Researchers have discovered Interferon-lambda...
Published: 4/8/2024   |   Inventor(s): Liudmila Prokunina-Olsson, Thomas O'Brien, Brian Muchmore, Raymond Donnelly, Patricia Porter-Gill
Keywords(s): HCV, hepatitis C virus, HepC, IFN L4, IL28B, INTERFERON, Interferon-lambda 4
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Diagnostics
Griffithsin-Based Anti-viral Therapeutics with Improved Stability and Solubility
Abstract: Griffithsin is a potent anti-viral protein with activity against HIV, HCV, Sars, HSV 1 & 2 and other viruses.  It is active against HIV and HCV at picomolar concentrations.  Griffithsin is moving into clinical trials as an anti-HIV microbicide. Based on the structure of griffithsin and the necessities of pharmaceutical product development...
Published: 7/16/2024   |   Inventor(s): Barry O'Keefe, Kenneth Palmer, Tinoush Moulaei, Lisa Rohan, Joshua Fuqua, Lindsay Kramzer
Keywords(s): Anti-Viral, cnidarin, Griffithsin, HCV, HIV, HSV, SARS
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease
Novel Enzyme-Based Immunoassay for Simultaneous Detection of Hepatitis C Virus Antigen and Antibody in Human Serum or Plasma
CDC scientists have developed a novel enzyme immunoassay for the simultaneous detection of hepatitis C virus (HCV) core antigen and circulating HCV antibodies. Serological testing procedures for HCV circulating antibodies are well established. There is, however, a window of time between HCV infection and seroconversion that generates an opportunity...
Published: 10/28/2024   |   Inventor(s): Yury Khudyakov
Keywords(s): ANTIBODY, Antibody-based, Antibody-dependent, ANTIGEN, Antigen Antibody, ANTIGEN CAPTURE ASSAY, Antigen/Ab, Antigen/antibody, ANTIGEN-ANTIBODY, Antigen-binding, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, Detection, detection system, Diagnosis, diagnostic, diagnostic in vitro, Diagnostic Kit, EIA, HCV, Hepatitis, HEPATITIS C, HEPATITIS C DIAGNOSTIC, HEPATITIS C HCV, Human, ivd, LATERAL, Novel, OID-NCHHSTP-DVH, PLASMA, SERA, SIMULTANEOUS, viral, VIRAL DIAGNOSTIC, virus, VLXXXX, WBXXXX, WFXXXX, WIXXXX, XAXXXX, XCXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Consumer Products, Application > Diagnostics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, ResearchProducts > Antibodies
A Novel System for Producing Infectious Hepatitis C Virus (HCV) Virions and Development of a Novel Reporter System for Studying HCV Entry
HCV has infected an estimated 3% of the world population in whom viral infection persists for more than two third of the cases, often resulting in life-threatening complications. The standard of care (pegylated interferon alpha-2 plus ribavirin) is efficient in only 50% of treated patients, costly and has numerous side effects. In addition, viral resistance...
Published: 10/28/2024   |   Inventor(s): Edward Berger, Miriam Triyatni, Bertrand Saunier
Keywords(s): AC4XXX, ACXXXX, AXXXXX, BBXXXX, Biotechnology, C, DB4BXX, DB4XXX, DBXXXX, Development, DXXXXX, Entry., Flavivirus-based, HCV, HCV:, Hepatitis, Hepatitis A, Hepatitis D, Hepatitis E, INFECTIOUS, Novel, Patent Category - Biotechnology, production, REPORTER, STUDYING, System, Virion, VIRIONS, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Neutralization of Hepatitis C Virus (HCV)
Available for licensing and commercial development are compositions and methods for preventing and/or treating infection caused by hepatitis C virus (HCV). The invention is based on mapping studies conducted by the inventors of two epitopes within HCV E2: epitope I and epitope II. It has been discovered that epitope I is involved in virus neutralization...
Published: 10/28/2024   |   Inventor(s): Pei Zhang
Keywords(s): antibodies, ANTIBODY, BINDING, C, Chromosome 7, monosomy, CONTROL, DB4BXX, DB4XXX, DBXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, Deletion 7, DXXXXX, E2, HCV, HCV Vaccine, Hepatitis A, Hepatitis D, Hepatitis E, Hepititis, Heptitis, Infection, Interference-mediated, INTERFERING, Methods, Modulate, Neutralization, Patent Category - Chemistry, Protein, SITE, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Therapeutics