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Microfluidic Digital Nanobiosensor for Point-of-Care Detection of NT-proBNP
Heart failure is a serious global burden affecting more than 64 million people worldwide. It has high morbidity and mortality and poor quality of life, making it a major public health priority. N-terminal proBNP (NT-pro-BNP) is a well-established clinical biomarker for monitoring and managing heart failure. Regular and frequent monitoring of patients...
Published: 9/3/2024   |   Inventor(s): Shaopeng Wang, Chao Chen
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Devices
Label-free Single-molecule Immunoassay Technique
Detection and quantification of low-abundance biomarkers is essential to early disease detection, monitoring and treatment. While many techniques, have been developed for measuring single molecules, all require signal amplification, via enzyme amplification, or fluorescence or gold nanoparticle probes, which come with their own unique drawbacks, including...
Published: 9/3/2024   |   Inventor(s): Shaopeng Wang, Xiaoyan Zhou
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Imaging, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Devices
Breath-Based Diagnostics for Lower Respiratory Infections
Acute pulmonary infections, or pneumonia, are a leading cause of infectious death worldwide with more than 2.3 million deaths each year. Existing strategies for diagnosing pneumonia are based on clinical, radiological and microbial criteria, which is time-consuming, low accuracy, and subject to interobserver variability. Furthermore, obtaining a lower...
Published: 9/3/2024   |   Inventor(s): Heather Bean, Emily Higgins Keppler
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Diagnostic Assays/Devices
Microfluidic Digital Nanobiosensors for Point-of-Care Detection of Analytes
Detection, identification and quantification of molecular biomarkers, such as proteins, peptides, exosomes, hormones, neurotransmitters, metabolites and nucleic acids, are critical to disease diagnosis, progression monitoring, and management. While there are numerous approaches for analyzing biomarkers, the most validated and well-established is ELISA....
Published: 8/27/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Cancer, Imaging, Life Science (All LS Techs), Medical Devices, Medical Diagnostics/Sensors
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government’s pursuit of the “Thousand Dollar Genome” and the “X Prize” goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will...
Published: 8/22/2024   |   Inventor(s): Stuart Lindsay, Colin Nuckolls, Jinyao Tang, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Proteomic Assays/Reagents/Tools
DNA Sequencing by Molecular Recognition and Nanoscale Manipulation of Single Molecules
The US Government's pursuit of the "Thousand Dollar Genome" and the "X Prize" goal of even lower cost DNA sequencing are striking examples of the importance being assigned to advances in methods for the DNA sequencing of the human genome. The first technology that finally allows for truly routine genome sequencing will open a new...
Published: 8/22/2024   |   Inventor(s): Stuart Lindsay, Jin He, Peiming Zhang, Kevin Reinhart
Keywords(s):  
Category(s): Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools
Mapping Targets of Antibody Binding
The use of monoclonal antibodies (mAbs) in research, diagnostics and therapeutics is ubiquitous, particularly because of their ability to simultaneously achieve high affinity and specificity. mAbs binding typically involves interactions between it and 5-8 amino acids in a specific spatial arrangement. These interactions at defined positions is what...
Published: 8/13/2024   |   Inventor(s): Neal Woodbury, Laimonas Kelbauskas, Akanksha Singh, Pritha Bisarad
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Computing & Information Technology, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Pharmaceuticals
Device to Hold and Image Cell Culture Flasks and Biodome Technologies
Labware receptacles, such as cell culture flasks or biodomes, are ubiquitous tools in cellular biology research which allow for growing as well as imaging cells. However, many labware receptacles face challenges when trying to image them, such as an inability to lay flat against the stage of a microscope, or to reproducibly place the receptacle in the...
Published: 7/29/2024   |   Inventor(s): Barbara Smith, Ethan Marschall, Jarrett Eshima
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Imaging, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Medical Devices
Incorporation of Functional Additive for Byproduct Control in Thermosetting Systems
Background Bismaleimides (BMIs) and acrylates are key monomers in polymer science, valued for their thermal stability, mechanical properties, and reactivity. They are widely used in high-performance applications including aerospace and 3D printing. However, their current applications are mostly limited to polymeric matrices for thermosets and thermoplastics....
Published: 7/8/2024   |   Inventor(s): Jose Sintas, Timothy Long
Keywords(s):  
Category(s): Physical Science, Bioanalytical Assays, Chemistries & Devices, Advanced Materials/Nanotechnology
Anti-Galectin-1 Monoclonal Antibody
Galectin-1 (Gal-1) is a ubiquitously expressed galactoside-binding 14-kDa lectin that is differentially expressed by a variety of pathological as well as normal cell types. Extracellular Gal-1 has been shown to exert strong Immunomodulatory activity and has been implicated in numerous cancer and autoimmune diseases. Further, recent research has shown...
Published: 7/2/2024   |   Inventor(s): Douglas Lake, Kirsten Pfeffer, Thai Ho
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Cancer, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
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