Search Results - lymphocyte

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Mice, Organs, and Mouse Alleles Carrying Germline and Conditional Deletions of the Zbtb7b Gene
Abstract: The Zbtb7b gene encodes the zinc finger transcription factor ThPOK (also known as cKrox) that promotes CD4 lineage differentiation in immature T cells. CD4+ T cells, also known as “helper” T cells, are critical for long-term immunity against pathogens as well as for promoting CD8+ “effector” T cell and effective B cell responses. ThPOK is...
Published: 5/8/2024   |   Inventor(s):  
Keywords(s): Autoimmunity, Bosselut, CANCER, CD4, cKrox, Helper T Cell, Infection, LYMPHOCYTE, Memory T Cell, Oncology, ThPOK, transgenic mice, Zbtb7b, Zinc Finger Transcription Factor
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Research Materials, TherapeuticArea > Immunology
Alloreactive T Cell Depletion Method For Preventing Graft-Versus-Host Disease
The invention relates to the use of adenosine to deplete alloreactive T cells from donor grafts to prevent graft-versus-host disease (GVHD). The method includes culturing donor cells that include T cells with recipient antigen presenting cells (APCs) to form a mixture of cells. The recipient’s APCs activate donor T cells. The activated T cells are...
Published: 10/28/2024   |   Inventor(s): Gregory Whitehill, John Barrett, Dhanalakshmi (Donna) Chinnasamy
Keywords(s): Alloreactive, Cell, DEPLETION, Disease, DONOR, GRAFTS, GRAFT-VERSUS-HOST, GVHD, Listed LPM Maddox as of 4/15/2015, LYMPHOCYTE, lymphocytes, Method, Novel, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Prevent, SELECTIVE, Stem, T, YAXXXX
Category(s): Collaboration Sought > Licensing