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Abstract Hydrogen sulfide (H2S) has demonstrated several essential critical care benefits when delivered properly in low doses. The current state-of-the-art delivery systems rely on gaseous delivery of H2S to patients. WSU researchers have developed chemical agents that controllably decompose to release H2S and demonstrated their efficacy in biological...

Published: 6/4/2025 | Inventor(s): Ming Xian, Hua Wang, Yu Zhao

Keywords(s): Chemistry

Category(s): Technologies > Health & Well-being > Chemistry, Technologies > Health & Well-being > Pharmaceutical

DNA Nanocaged Enzymes

Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...

Published: 2/13/2025 | Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao

Keywords(s): Bioanalysis, Catalysis, Enzymes

Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors

Biological H2S / COS Donation by Thiocarbamates

1. Technology Overview The invention focuses on biological hydrogen sulfide (H₂S) and carbonyl sulfide (COS) donation using thiocarbamates. These compounds release COS, which is then converted to H₂S by hydrolysis or metabolism by carbonic anhydrase. The technology is currently in the development stage, with promising cross-industry applications in...

Published: 1/7/2026 | Inventor(s): Michael Pluth, Andrea Steiger, Yu Zhao

Keywords(s):

Category(s): Chemistry, Physical Science, Therapeutics

Compounds for Thiol-Triggered COS and/or H2S Release and Methods of Making and Using the Same

1. Technology Overview The invention focuses on thiol-triggered sulfenyl thiocarbonates and sulfenyl thiocarbamates that release carbonyl sulfide (COS) and hydrogen sulfide (H₂S) in the presence of biologically relevant thiols. These compounds offer a concomitant fluorescence response, providing optical indication of COS and H₂S release. The technology...

Published: 1/2/2026 | Inventor(s): Michael Pluth, Yu Zhao, Matt Cerda

Keywords(s): Science

Category(s): Chemistry, Engineering, Medical Devices, Physical Science, Therapeutics

2015-182 FLEXIBLE BALLOON-INFLATABLE ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY TO ASSESS ENDOLUMINAL LIPID-RICH LESIONS

Case No. 2015-182SUMMARYUCLA researchers have developed a novel flexible balloon-inflatable electrochemical impedance spectroscopy to facilitate the diagnosis of metabolically active atherosclerotic lesions.BACKGROUNDIdentifying metabolically active atherosclerotic lesions remains an unmet clinical challenge during coronary intervention. Detection of...

Published: 7/17/2025 | Inventor(s): Fei Yu, Yu-Chong Tai, Yu Zhao, Tzung Hsiai

Keywords(s): Cardiovascular, Medical Devices and Materials, Monitoring And Recording Systems

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Therapeutics > Cardiovascular

Chance-Constrained Optimization for Treatment of Prostate and Other Cancers in Intensity-Modulated Proton Therapy

The quality of IMPT treatment plans may be drastically diminished by uncertainties such as proton range and patient setup errors. If these uncertainties are not figured into treatment planning, the dose distribution that the patient receives may not be the same as the planned dose distribution. New treatment plans, which include optimized software/programming,...

Published: 7/4/2025 | Inventor(s): Jianming Liang, Yu An, Wei Liu

Keywords(s):

Category(s): Computing & Information Technology, Life Science (All LS Techs), Medical Imaging

Double Heterostructure Solar Cells and Photodetectors Based on MgCdTe Absorbers

Multi-layered CdTe solar cell devices have properties that are promising but face low conversion efficiencies and high manufacturing costs. In contrast to typical monocrystalline Si and GaAs materials, CdTe cells are made up of polycrystalline materials and thus, have poor open circuit voltages which are responsible for the low efficiencies. Therefore,...

Published: 2/13/2025 | Inventor(s): Yong-Hang Zhang, Yuan Zhao, Mathieu Boccard, Zachary Holman

Keywords(s): Materials and Electronics

Category(s): Advanced Materials/Nanotechnology, Alternative Energy, Applied Technologies, Chemical/Biological Sensors, Energy & Power, Environmental, Physical Science, Physics, Semiconductor Devices, Semiconductors, Materials & Processes