The quality of IMPT treatment plans may be drastically diminished by uncertainties such as proton range and patient setup errors. If these uncertainties are not figured into treatment planning, the dose distribution that the patient receives may not be the same as the planned dose distribution. New treatment plans, which include optimized software/programming, are needed to limit the influence of uncertainties and improve the robustness of treatment plans.
Researchers at Arizona State University in collaboration with researchers at the Mayo Clinic have developed a novel treatment planning method for use in radiation therapy for cancer patients. They applied a probabilistic framework in the IMPT planning subject to range and patent set up uncertainties. The framework hedges against the influence of uncertainties and improves robustness of treatment plans. Results from this method were compared with the conventional PTV-based method and demonstrated enhanced effectiveness. The total deviation between the real and prescribed dose is minimized under the nominal scenario to provide a convenient framework for treatment planners.
This tool generates superior IMPT plans compared to conventional methods with explicit control of plan robustness.
Potential Applications
Benefits and Applications
For more information about the inventor(s) and their research, please see Dr. Liang's directory webpage