Abstract
Hydrogen sulfide (H2S) has demonstrated several essential critical care benefits when delivered properly in low doses. The current state-of-the-art delivery systems rely on gaseous delivery of H2S to patients. WSU researchers have developed chemical agents that controllably decompose to release H2S and demonstrated their efficacy in biological tissues.
Applications and Advantages
§ Timed-release
§ Biocompatible
IP Status
US patent application issued: US9096504B2 - Controlled chemical release of hydrogen sulfide - Google Patents
Publications
Zhao, Y.; Wang, H.; Xian, M.; Cysteine activated hydrogen sulfide (H2S) donors. J. Am. Chem. Soc., 2011, 133, 15.
Zhao, Y.; Bhushan, S.; Yang, C.; Otsuka, H.; Stein, J.D.; Pacheco, A.; Peng, B.; Devarie, N.O.; Aguilar, HC; Lefer, D.J.; Xian, M.; Controllable hydrogen sulfide donors and the activity against myocardial ischemia-reperfusion injury. ACS Chem. Biol. 2013, in press.
See trade magazine article at: http://cen.acs.org/articles/91/web/2013/04/Hydrogen-Sulfide-Donors-Protect-Heart.html