Search Results - yanzhao+lu

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A Wearable Multi-Functional Ophthalmic Device for Monitoring Oculomotor Components
The invention is a wearable ophthalmic device designed to monitor various aspects of eye function crucial for clear vision. It combines several diagnostic capabilities into a single, user-friendly device. These capabilities include capturing detailed images of the retina (fundus), tracking eye movements accurately, and measuring how well the eyes adjust...
Published: 7/22/2024   |   Inventor(s): Hong Hua, Yanzhao Lu
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics > Ophthalmology, Technology Classifications > Imaging & Optics > Lens & System Design, Technology Classifications > Imaging & Optics > Displays
Viral-Targeted Nanostructured Drug (VTND) Platform
The outbreak of COVID-19 and subsequent mutant variants has caused millions of deaths and severe acute respiratory illness worldwide. Therapeutics such as monoclonal antibodies, small molecule drugs inhibiting viral replication and immune modulators suppressing hyperinflammation have shown promise, but each comes with limitations including viral variant...
Published: 10/24/2024   |   Inventor(s): Hao Yan, Yang Xu, Deeksha Satyabola, Yize (Henry) Li, Abhay Prasad
Keywords(s):  
Category(s): COVID-19, SARS-CoV-2, Coronavirus, Advanced Materials/Nanotechnology, Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Label-Free Detection Platform for CircRNAs
Circular RNAs (circRNAs) hold great potential as novel biological and clinical biomarkers for diagnosis and prognosis of cancer and other diseases. Conventional detection techniques such as northern blotting, microarray, qRT-PCR and RNA-seq suffer from many issues including low sensitivity and background noise, which limit the use of circRNA in clinical...
Published: 1/19/2024   |   Inventor(s): Hao Yan, Yang Xu, Shaopeng Wang, Zijian Wan, Liangxiao Chen
Keywords(s):  
Category(s): Life Science (All LS Techs), Medical Diagnostics/Sensors, Imaging, Advanced Materials/Nanotechnology, Biomaterials, Bioanalytical Assays, Chemistries & Devices, Cancer
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
Structure Assisted Directed Evolution of Multivalent Ligands
Nanotechnology needs organization and precise control, which is why DNA self-assembly into nanostructures has been a remarkable breakthrough. The challenges in creating nanostructures and also the opportunities lie in how to achieve self-sustained replication. This allows for the system to amplify itself in unlimited cycles, which is not enabled in...
Published: 9/20/2024   |   Inventor(s): Hao Yan
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools
DNA Gridiron
Self-assembling nucleic acid molecules have been utilized extensively for constructing unique nanoscale structures, and designing increasingly complex structures is a top nanotechnology challenge. Current methods to create NDA nanostructures are restricted to discrete domains of parallel lines as a result of the double crossover based unit motif, which...
Published: 4/14/2023   |   Inventor(s): Dongran Han, Hao Yan
Keywords(s): DNA nanotechnology
Category(s): Advanced Materials/Nanotechnology, Life Science (All LS Techs), Biomaterials, Chemical/Biological Sensors, Genomic Assays/Reagents/Tools
Tumor-Targeted Killing with Aptamer-Nucleic Acid Nanostructures
Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...
Published: 4/14/2023   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s): Bio-Technology, Drug Screening, Therapeutics
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools
Creation of Multivalent Aptamers to Target Effector T Cells to Attack Tumor Cells
Despite decades of research effort, cancer remains one of today’s most pressing health concerns. Present day treatment methods tend to include debilitating side effects mainly due to low specificity of the treatments. Recently, some attempts have been made to augment tumor immunity by using bi-specific, hybrid antibodies that direct immune cells...
Published: 4/14/2023   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s):  
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools, Pharmaceuticals
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/23/2023   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/23/2023   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
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