Search Results - john+chaput

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Synbodies - High Throughput Development of Synthetic Antibodies
The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the immunized...
Published: 2/23/2023   |   Inventor(s): Stephen Johnston, Neal Woodbury, John Chaput, Chris Diehnelt, Hao Yan
Keywords(s):  
Category(s): Life Science (All LS Techs), Diagnostic Assays/Devices, Bioanalytical Assays, Chemistries & Devices, Proteomic Assays/Reagents/Tools
HT Fusion Tag Detection
Because of their unique recombinant properties, fusion proteins are of intense interest in many biotechnology applications. Current methods to specifically detect expression of fusion proteins exist; but, they are either unsuitable for high throughput (HTP) processes, in the case of western blots, or are non-qualitative, in the case of ELISAs. Assessment...
Published: 2/23/2023   |   Inventor(s): Justin Saul, Ji Qiu, Joshua LaBaer, Mitch Magee, John Chaput, Sujay Sau
Keywords(s): Fluorescence, Protein Assays
Category(s): Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Replication System, Novel Polymerases, and Uses for Threose Nucleic Acid
Synthetic genomics, though a relatively nascent field, is generating a lot of excitement in the scientific community, especially with the advent of unnatural nucleic acid polymers. Threose nucleic acid (TNA) is one such unnatural nucleic acid polymer that is particularly promising because of its high resistance to nuclease degradation, making it much...
Published: 2/23/2023   |   Inventor(s): John Chaput
Keywords(s): Diagnostics, Drug
Category(s): Cancer Therapeutics, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Non-Cancer Therapeutics
Highly Sensitive Optical Sensor for Polymerase Screening
The field of synthetic genetics is generating a lot of excitement in the synthetic biology community, especially with the advent of xeno-nucleic acid polymers (XNAs) that can be replicated by standard molecular biology techniques. DNA and RNA have had limited utility in diagnostics and therapeutics because of their rapid degradation by nucleases. XNA...
Published: 2/23/2023   |   Inventor(s): John Chaput, Andrew Larsen, Matthew Dunn
Keywords(s): Polymerase Engineering
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools