Search Results - xingyi+zhou

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Repurposing CDK Inhibitors for the Treatment of Zika Virus Infection
This invention includes the discovery and use of a group of CDK inhibitors that were found during a drug repurposing screen designed to find compounds that inhibit Zika virus caused cell death. The identified CDK inhibitors have all previously been used in clinical trials for other diseases, potentially reducing the long time course needed for new drug...
Published: 10/28/2024   |   Inventor(s): Ruili Huang, Miao Xu, Wenwei Huang, Hengli Tang, Emily Lee, Cheng YiChen, Yi Zhou, Hongjun Song, Guo-Li Ming, Zhexing Wen, Wei Zheng
Keywords(s): CDK, Infection, Inhibitors, Repurposing, treatment, VEXXXX, virus, VLXXXX, WIXXXX, WKXXXX, Zika
Category(s): TherapeuticArea > Neurology, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials
Atmospheric water irrigation enabled by super moisture absorbent gels
Overview The global population is projected to reach 9.6 billion people by 2025, requiring food production to increase by 70% to meet the demand of the huge population. Water is most limiting natural resource for agricultural production due to the freshwater shortage and enormous need for irrigation. Dry cropland accounts for 84% of the cultivated...
Published: 1/11/2024   |   Inventor(s): Guihua Yu, Fei Zhao, Xingyi Zhou
Keywords(s):  
Category(s): Physical sciences > Materials, Physical sciences > Green tech, Physical sciences > Environment, Life sciences > Agriculture
BIOSENSOR DETECTION ASSAY FOR ANTI-SARS-COV-2 ANTIBODIES
BIOSENSOR DETECTION ASSAY FOR ANTI-SARS-COV-2 ANTIBODIES Researchers at UCSF and the Chan Zuckerberg Biohub have developed a serological detection assay for anti-SARS-CoV-2 antibodies. COVID-19, caused by the SARS-CoV-2 virus, has spread throughout the world. Early detection of disease using viral detection assays is critical for containing the spread...
Published: 3/17/2023   |   Inventor(s): James Wells, Susanna Elledge, Xin Zhou
Keywords(s): Antibody, Biosensor System, Diagnosis, Epitope Shield, IgG
Category(s): Technology Classifications > Biology
ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION
ENGINEERED ACE2 RECEPTOR TRAPS TO BLOCK SARS-COV-2 INFECTION Researchers at UCSF and the Chan Zuckerberg Biohub have developed a set of ACE2 variants which potently block SAR-CoV-2 infection in cells. SARS-CoV-2 is the stain of coronavirus that causes COVID-19. This virus is characterized by spike proteins on its surface, which mediate infection...
Published: 3/17/2023   |   Inventor(s): James Wells, Tanja Kortemme, Jeff Glasgow, Anum Glasgow, Irene Lui, Xin Zhou
Keywords(s): Affinity Reagent, Biomolecules, Therapeutic, Yeast Particle Display
Category(s): Technology Classifications > Biology
DETECTION ASSAY FOR SARS-COV-2 VIRUS
DETECTION ASSAY FOR SARS-COV-2 VIRUS Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to detect SARS-CoV-2 virus. Clinical laboratory tests and point-of-care tests are needed for screening and diagnosis of individuals infected with SARS-CoV-2 virus. SARS-CoV-2 infection begins with viral Spike protein binding to the human...
Published: 3/17/2023   |   Inventor(s): James Wells, Susanna Elledge, Xin Zhou, Tanja Kortemme, Jeff Glasgow, Anum Glasgow, Irene Lui
Keywords(s): Affinity Reagent, Antibody, Biosensor System, Diagnosis, Fc Domain
Category(s): Technology Classifications > Biology
Targeted Neoantigen Vaccination in H3G34R/V Glioma (UCLA Case No. 2021-008)
UCLA researchers in the Departments of Neurosurgery and Microbiology, Immunology, and Molecular Genetics have developed an immunotherapy treatment methodology for H3G34R/V high-grade glioma, providing an ability to be adapted toward a wide range of similar tumors.BACKGROUND:Over 3000 gliomas and other forms of brain cancer are diagnosed in children...
Published: 5/4/2024   |   Inventor(s): Anthony Wang, Geoffrey Owens, Yi Xing, Robert Prins, Linda Liau, David Nathanson
Keywords(s): Immunotherapy, Oncology, Oncology Immunotherapy
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy
Identification of a Platform for T Cell Receptor Recognition of Splice Variation Neoantigens in Glioblastoma (UCLA Case No. 2019-693)
UCLA researchers in the Departments of Neurosurgery and Pharmacology have developed a novel platform for the identification of alternative splice variants unique to cancer cells, for use as neo-epitope vaccines or as T cell Receptor-based cell therapy of brain cancer. BACKGROUND:T cells are a type of lymphocyte that play a central role in immune response...
Published: 5/20/2024   |   Inventor(s): Robert Prins, Yi Xing
Keywords(s): Diagnostic Markers & Platforms, Oncology, Therapeutics & Vaccines
Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy
IRIS: Isoform Peptides from RNA Sequencing for Immunotherapy Targets Screening
UCLA Case No. 2018-916SUMMARYResearchers led by Dr. Xing from the Department of Microbiology, Immunology, and Molecular Genetics at UCLA have developed a big data approach to identify targets for personalized cancer immunotherapy. BACKGROUNDImmunotherapies aim to use the patient’s own immune system to fight cancerous cells, but to be...
Published: 7/19/2023   |   Inventor(s): Yi Xing, Yang Pan, Taegyun Yang, Yuanyuan Wang
Keywords(s):  
Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics > Oncology > Oncology (Small Molecules), Software & Algorithms > Data Analytics
DARTS: Deep Learning Augmented RNA-seq Analysis of Transcript Splicing
SummaryResearchers led by Yi Xing have developed a novel deep learning algorithm to detect alternative splicing patterns in RNA-seq dataBackgroundDevelopment of genetic sequencing tools like RNA-seq has ushered in an age of big data in genomics and transcriptomics. Collective efforts like ENCODE and the Roadmap Epigenomics Project (REP) have accelerated...
Published: 7/19/2023   |   Inventor(s): Yi Xing, Zijun Zhang
Keywords(s): Life Science Research Tools, Nucleic Acid Platform Systems, Research Methods, Software, Targets And Assays, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Software & Algorithms > Programs