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A novel molecular target for the treatment of heart failure with preserved ejection fraction

Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy Overview Cardiac hypertrophy, a key risk factor for heart failure and sudden cardiac death, arises from hemodynamic and neurohormonal stress, often culminating in adverse remodeling. While much of the focus has been on activators of hypertrophic signaling, this technology identifies...

Published: 8/13/2025 | Inventor(s): Mukesh Jain, Xudong Liao, Tapatee Das, Yosuke Nagai

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Category(s): Therapeutics