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Search Results - binghe+wang
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Highly Selective and Sensitive Carbon Monoxide Probe
Description This technology is a suite of fluorescent reagents for imaging and quantifying carbon monoxide (CO) in biological samples such as cells, tissue, and blood. Compared to existing methods of CO sensing and quantification for research, these CO detection probes feature CO sensing exclusivity, ultralow background fluorescence, ultrahigh sensitivity,...
Published: 4/8/2025
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Inventor(s):
Binghe Wang
,
Xiaoxiao Yang
Keywords(s):
Category(s):
Diagnostic
,
Research Tool
,
Assay
Highly Effective Small Molecules for Cancer Treatment
Description This technology is a series of innovative small molecules demonstrating significant in-vitro anticancer activity. Isolated from a previously unstudied medicinal plant species, these compounds expand the potential of natural products in drug discovery. Previous studies on related plant species have identified compounds with a broad spectrum...
Published: 4/10/2025
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Inventor(s):
Paulos Yohannes
,
Binghe Wang
Keywords(s):
Category(s):
Therapeutics
Hydrogen Sulfide-Releasing Therapeutics Reduce NSAID Toxicity and Provide Protection During Stroke
Description This technology is a suite of hydrogen sulfide (H2S) prodrugs that has broad applicability for decreasing toxicity during the treatment of inflammation using NSAIDs. In vivo studies have demonstrated reduction of gastrointestinal ulcers, kidney toxicity, and liver toxicity during NSAID use. In separate in vivo studies, these technologies...
Published: 4/8/2025
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Inventor(s):
Binghe Wang
,
Yueqin Zheng
Keywords(s):
Category(s):
Therapeutics
,
Research Tool
Highly Effective Therapeutics to Overcome Antibiotic Resistance
Description This technology is a series of small molecules that enhance antibiotic effectiveness in treating bacterial infections. These compounds not only sensitizes resistant bacteria to enable more effective treatment, but also act as an antibiotic adjuvant to allow lower antibiotic doses to be used. The lead compound has been shown to sensitize...
Published: 3/24/2025
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Inventor(s):
Binghe Wang
,
David Boykin
,
Manjusha Choudhury
,
Arvind Kumar
,
Bingchen Yu
,
Mengyuan Zhu
Keywords(s):
Category(s):
Therapeutics
Highly Effective, Tunable, Intracellular CO Therapeutics
Description This technology is a series of organic carbon monoxide (CO) prodrugs that release the gasotransmitter CO in a controllable fashion in response to various stimuli (pH changes, ROS, enzymes, etc.). CO is a gasotransmitter with critical physiological functions in mammals. Its biological importance is on par with that of nitric oxide (NO),...
Published: 3/24/2025
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Inventor(s):
Binghe Wang
,
Ce Yang
Keywords(s):
Category(s):
Therapeutics
PSMA-Targeted CAR-T Therapy for Castration-Resistant Prostate Cancer
This invention includes ten novel PSMA-targeted CAR-T therapies to treat castration-resistant prostate cancer. The CAR-T constructs were generated using scFvs from five different mouse hybridomas. We have further enhanced the lead PSMA-targeted CAR-T therapy by co-expressing IRF4 to regulate effector T cell activity and tissue infiltration. The co-expression...
Published: 10/1/2024
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Inventor(s):
Bin He
Keywords(s):
Category(s):
Technology Classifications > Therapeutic > Biologics
,
Technology Classifications > Therapeutic > Cell and Gene Therapies
,
Clinical Area > Cancer
,
Research Area > Cancer