Search Results - techpub+algolia+%3e+therapeutics

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Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease. Key Benefits Improved cellular uptake and protein suppression using antisense oligos. Longer ASO half-life compared to other ASO delivery methods. Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 8/22/2024   |   Inventor(s): Khalid Salaita, Radhika Sharma
Keywords(s): Biomaterials, Cardiovascular, Chemistry, Oncology
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery, TechPub Algolia > Micro and Nanotechnology
Optimizing the Engineering of CAR-T Cells
Application A method for selecting distinct T cell populations in order to generate more effective CAR-T cells. Key Benefits The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells. This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 7/30/2024   |   Inventor(s): Byron Au-Yeung
Keywords(s): Cell/Gene Therapy, Oncology
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
Advancing Lymphatic Endothelial Cell Generation from iPSCs
Application The developed protocol offers a reproducible and scalable method for generating lymphatic endothelial cells (LECs) from induced pluripotent stem cells (iPSCs), addressing critical challenges in the field of lymphatic-related therapies. Key Benefits Reproducible and scalable protocol for generating LECs from iPSCs. Utilizes specific...
Published: 8/22/2024   |   Inventor(s): Katherine Hekman, Katherine Owsiany
Keywords(s): Cell/Gene Therapy
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery
Technology for Assessment in Enhancing Memory Measurement in ECT Therapy
Application The Electroconvulsive Cognitive Assessment (ECA) is a 10-minute cognitive exam designed for use during and after Electroconvulsive Therapy (ECT). It focuses on assessing memory deficits associated with ECT, offering a quick and targeted evaluation tool for healthcare professionals. Key Benefits Rapid cognitive assessment in under 10...
Published: 7/30/2024   |   Inventor(s): Adriana Hermida
Keywords(s): Neuroscience/Pain
Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Therapeutics
Indolium 1 for Advanced Melanoma Treatment
Application A small molecule compound for the treatment of melanoma. Key Benefits Novel small molecule compound for the treatment of resistant melanoma. Well tolerated in vivo. Market Summary Malignant melanoma is a type of skin cancer that begins in melanocyte cells. Melanoma is the 19th most commonly occurring cancer. Exposure to UV radiation...
Published: 7/30/2024   |   Inventor(s): Jack Arbiser
Keywords(s): Dermatology, Oncology, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Human Brain Proteins with Evidence Consistent with Causality of Alzheimer’s and Depression
Application Research and therapeutic targets for Alzheimer’s disease, depression, and other neurological conditions mediated by protein expression in the brain. Key Benefits These findings can be utilized as a research tool to better understand the genetic basis of Alzheimer’s disease. Can also be utilized to develop therapeutics for...
Published: 8/22/2024   |   Inventor(s): Aliza Wingo, Thomas Wingo, Yue Liu, Allan Levey, Nicholas Seyfried, Duc Duong
Keywords(s): Neuroscience/Pain, Target
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
Combination Antibiotic Therapy to Exploit Multiple Heteroresistance
Application Treatment with combinations of FDA-approved antibodies targeting small drug-resistant cell populations for infectious disease. Key Benefits Specific combinations of existing drugs that target small subpopulations of bacterial cells resistant to many standard of care treatment regimens. Potential to overcome the drug resistance crisis...
Published: 8/22/2024   |   Inventor(s): David Weiss, David Hufnagel, Victor Band
Keywords(s): Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Therapeutics
Vaccines and Antibody Therapeutics for HPV-related Cancers
Application Treatment and prevention of HPV-induced malignancies. Key Benefits Identification of a protein expressed in a large number of HPV-induced cancers. Antibodies have been generated that bind to the protein and potentially elicit an immune response to the cancer cells. The antibodies can be used to develop new treatments and vaccines...
Published: 7/30/2024   |   Inventor(s): Rafi Ahmed, Andreas Wieland
Keywords(s): Biologic, Microbiology/Infectious Diseases, Oncology
Category(s): TechPub Algolia > Therapeutics
EF-Tu Targeting Antibody for Infection Treatment
Application Therapeutic monoclonal antibodies directed to Elongation Factor-Tu (EF-Tu) for the treatment of infections. Key Benefits An antibody that targets the protein EF-Tu, which is present on many types of bacteria involved in life-threatening infections. A research-grade antibody has been developed with animal data showing the ability to...
Published: 7/30/2024   |   Inventor(s): Joanna Goldberg, Dina Moustafa
Keywords(s): Microbiology/Infectious Diseases, Target, Vaccine
Category(s): TechPub Algolia > Vaccines, TechPub Algolia > Therapeutics
Antisense Restoration of ELAVL3 for Neurological Diseases
Application Antisense therapeutics targeting ELAVL3 expression for neurodegenerative disorders. Key Benefits Antisense approach for restoring protein levels and function of ELAVL3 and TDP-43. Preclinical data show the ability of several ELAVL3-targeting ASOs to restore protein expression via in vitro experiments. Potential to be a new medicine...
Published: 8/22/2024   |   Inventor(s): Zachary X McEachin
Keywords(s): Neuroscience/Pain
Category(s): TechPub Algolia > Therapeutics
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