Search Results - technology+classifications+%3e+therapeutics

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Human Artificial Chromosome Generation Technology
Technology allowing efficient formation, delivery, isolation, and enrichment of single-copy Human Artificial Chromosome (HAC) for use in research, plant production, gene and cell therapy and more. Problem: Existing gene-editing techniques have limitations due to their reliance on viruses for delivery, restricting their packaging capacities. A more potent...
Published: 9/18/2025   |   Inventor(s): Ben Black, Craig Gambogi, John Glass, David Brown, Gabriel Birchak
Keywords(s): Bioengineering, Gene Editing, Gene Therapy, Genetic Disorders, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Chemogenetic Treatment for Neurodegenerative and Neuropsychiatric Disorders
yle> ​ DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like...
Published: 9/12/2025   |   Inventor(s): Gary Aston-Jones, Hannah Bowrey
Keywords(s):  
Category(s): Technology Classifications > CNS Disorder, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
Unlocking the Power of Device-Free Cold Plasma for Tumor Sensitization
Current cancer treatments like chemotherapy and radiation often struggle to target cancer cells without harming healthy tissue. Many tumors—especially aggressive or drug-resistant types—remain difficult to treat due to limited drug penetration, poor selectivity, and systemic toxicity. There is a pressing need for a method that can sensitize...
Published: 9/16/2025   |   Inventor(s): Michael Keidar, Dayun Yan
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Buffers and Media, Technology Classifications > Therapeutics, Technology Classifications > Therapeutics > Small Molecules
In situ gel vehicle for ophthalmic drug delivery
​ Polymer compositions were screened with amplitude oscillation and show synergistic effects with simulated tear fluid Invention Summary: Effective ophthalmic drug delivery remains a significant challenge due to the eye’s natural defense mechanisms, including blinking, tear turnover, and nasolacrimal drainage, which rapidly clear topically...
Published: 8/28/2025   |   Inventor(s): Patrick Sinko, Benjamin Yee, Dayuan Gao
Keywords(s):  
Category(s): Technology Classifications > Therapeutics
LNP + Squeeze: Enhancing Chimeric Antigen Receptor T-Cell Generation via Mechanoporation and Lipid Nanoparticles
Synergistic combination of mechanoporation and lipid nanoparticle (LNP) based transfection for an efficient, non-viral method of gene transfer to generate CAR-T cell therapies. Problem: Chimeric antigen receptor (CAR)-T cell therapy has transformed cancer treatment by engineering patients' T cells to precisely target and eradicate cancer cells....
Published: 8/28/2025   |   Inventor(s): Jina Ko, Jianhua Lim
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Immunology, Immunoncology, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis
Fluorescence Polarization Probe for identifying inhibitors of Enterovirus D68 2C
​ Design of the 2C fluorescence polarization probe Jun14157 and assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where...
Published: 8/20/2025   |   Inventor(s): Jun Wang, Kan Li
Keywords(s):  
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
“Y”-shaped symmetric Enterovirus D68 2C inhibitors are antiviral drug candidates
​ Graphical abstract describing design of “Y”-shaped symmetric 2C inhibitors. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis...
Published: 8/20/2025   |   Inventor(s): Jun Wang, Hiwot Demssie
Keywords(s):  
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
New SARS-CoV-2 papain-like protease inhibitor compounds are potent antiviral drug candidates
​ Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link). Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts...
Published: 8/8/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav
Keywords(s):  
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Treatment of viral induced cancers
Docket# S4039 Technology: Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus(KSHV) are human γ-herpesviruses associated with a broad spectrum of B-cell lymphomas typically in immune-compromised populations. There are no drugs which can specifically target EBV/KSHV-associated B-cell tumors. Using a High-throughput Screen...
Published: 8/7/2025   |   Inventor(s): Erle Robertson
Keywords(s): Oncology
Category(s): Technology Classifications > Therapeutics
A method for approximate searching very large files using Pigeonhole Principle
Big Data is the new term for the exponential growth of data in the Internet and traditional methods for searching large datasets with fuzzy criteria often rely on brute-force techniques, which can be inefficient and time-consuming. These approaches typically involve sequentially scanning through data, leading to performance bottlenecks, especially...
Published: 9/12/2025   |   Inventor(s): Maryam Yammahi, Simon (Semyon) Berkovich, Chen Shen
Keywords(s):  
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Computers Electronics & Software > Cloud Computing, Technology Classifications > Computers Electronics & Software > Databases
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