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Search Results - technology+classifications+%3e+therapeutics
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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Bin Tan
,
Prakash Jadhav
,
Kan Li
Keywords(s):
Antiviral
,
Small molecules
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Bin Tan
,
Prakash Jadhav
,
Ahmadullah Ansari
,
Francesc Ruiz Figueras
,
Edward Arnold
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Prakash Jadhav
,
Bin Tan
,
Haozhou Tan
Keywords(s):
Antiviral
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Specific inhibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia
Preliminary data shows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 7/31/2025
|
Inventor(s):
Yingxian Pan
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications
,
Technology Classifications > Therapeutics
Boosting Stem Cell Editing with CRISPR Nanoparticles
Invention Summary: Gene editing in hematopoietic stem cells (HSCs) holds immense promise for curing genetic blood disorders such as sickle cell anemia and β-thalassemia. However, a major hurdle lies in the safe, efficient, and targeted delivery of CRISPR/Cas9 systems into these delicate stem cells. There is a critical need for innovative...
Published: 7/23/2025
|
Inventor(s):
Jinglin Fu
,
Jian Huang
Keywords(s):
Category(s):
Technology Classifications > Cell Therapy
,
Technology Classifications > Cancer
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Nanotechnology
,
Technology Classifications > Therapeutics
Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis
Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL). Problem: ALS a neurodegenerative disease with poor prognosis. ALS is categorized into the familial and sporadic types, with the former accounting...
Published: 7/15/2025
|
Inventor(s):
Huafeng Wei
Keywords(s):
Genetic Disorders
,
Inflammation
,
Neurodegenerative Diseases
,
Neurology
,
Pulmonary
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Restoration of motor function through delayed intraspinal delivery of mRNA-encoded IL-10 after spinal cord injury
Brief Description: Disclosed herein is a composition including a nucleoside-modified mRNA encapsulated in a lipid nanoparticle wherein the nucleoside-modified mRNA encodes IL10, IL-6, MIP1a, GDNF (glial cell line-derived neurotrophic factor), or a combination thereof. A method of treated spinal cord injury is also described. Image: Caption: Reference...
Published: 7/9/2025
|
Inventor(s):
Norbert Pardi
,
Drew Weissman
Keywords(s):
Bioengineering
,
Drug Delivery
,
Gene Therapy
,
Immunology
,
Neurology
,
Regenerative Medicine
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
DNA Secondary Structure (G-quadruplex) Stabilizers Improve Muscle Repair in Acute Injuries, Exercise, and Aging
Essential stem cell maintenance genes, including Pax7, a transcription factor fundamental to preserving the high regenerative capacity of muscles, is induced via targeting DNA secondary structures. Problem: Tissue restoration is essential to maintain skeletal muscles after injury. Skeletal muscle regeneration is exclusively achieved by the bona fide...
Published: 6/13/2025
|
Inventor(s):
Foteini Mourkioti
,
Ji-Hyung Lee
Keywords(s):
Aging
,
Drug Target
,
Orthopedics
,
Regenerative Medicine
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Novel Antibiotic Inhibiting Elongation Factor Complex in Gram-Positive Bacteria
Invention Summary: Antibiotic resistance remains a global health challenge with millions of related deaths each year. Gram-positive bacterial infections, like those caused by Staphylococcus aureus, are likely to acquire and develop resistance to clinically available antibiotics. Therefore, it is crucial to identify and develop novel antibiotics...
Published: 6/5/2025
|
Inventor(s):
Wlodek Mandecki
,
Emanuel Goldman
,
Maxim Chudaev
,
Mark Henderson
,
Juan Marugan
,
Wenjuan Ye
,
Kenneth Wilson
,
Dane Parker
Keywords(s):
Antibacterial
,
Small molecules
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Synthesis of Non-steroidal Anti-Inflammatory Compounds to Promote Wound Healing
Graph shows the average skin punch biopsy weight of mice treated topically with nitrogen mustard (NM) to induce skin inflammation. Mice additionally treated with polyamine-imidazole conjugates showed a marked decrease in skin inflammation. Invention Summary: Non-steroidal Anti-Inflammatory drugs (NSAIDs) are widely available for over-the-counter...
Published: 7/9/2025
|
Inventor(s):
Jeffrey Laskin
,
Ned Heindel
,
Christophe Guillon
Keywords(s):
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Healthcare & Life Sciences
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