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Search Results - technology+classifications+%3e+therapeutics
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Glycosylated RNA in Exosome Extracellular Vesicles
Overview of experimental approach used to demonstrate exosome-mediated intercellular transfer of glycoRNAs Invention Summary: Exosomes play a significant role in diverse cellular functions and responses. These structures are believed to furnish cells with a signaling mechanism facilitated by the cargo enclosed within the exosome. This cargo...
Published: 5/28/2025
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Inventor(s):
Megerditch Kiledjian
,
Sunny Sharma
,
Xinfu Jiao
Keywords(s):
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Gene Therapy
Bitter Taste Receptor Combination Therapies for Treatment of Head and Neck Squamous Cell Carcinoma and Other Cancers
A method of combining T2R agonists and GLUT1 inhibitors to treat head and neck cancers. Problem: Head and neck squamous cell carcinoma (HNSCC) is a significant health concern with a high incidence and mortality rate. Approximately half of patients succumb to disease within 5 years. Current treatments for HNSCC include surgery, radiation therapy, chemotherapy,...
Published: 5/21/2025
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Inventor(s):
Ryan Carey
,
Robert Lee
,
Zoey Miller
Keywords(s):
Drug Delivery
,
Drug Target
,
Oncology
,
Surgery
Category(s):
Technology Classifications > Therapeutics
An iron oxide nanozyme formulation for augmenting the efficacy of oral care products.
A combinatory formulation for oral care products that enhances antimicrobial specificity, anti-plaque potency and prevents tooth decay. Problem: Tooth decay (dental caries), caused by the destruction of the outer layer (enamel) of teeth by bacteria in biofilms, affects nearly half of the global population and remains the most prevalent chronic disease...
Published: 4/25/2025
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Inventor(s):
Yue Huang
,
Hyun (Michel) Koo
,
David Cormode
Keywords(s):
Bioengineering
,
Dentistry
,
Infectious Disease
,
Microbiome
,
Nanotechnology
,
Platform Technology
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Materials
,
Technology Classifications > Therapeutics
Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells
A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected. Problem: Compounds which link native T-cells with the surface antigens found on cancer cells have emerged as an effective treatment for blood malignancies and are currently being developed for solid tumors....
Published: 4/16/2025
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Inventor(s):
Michael Mitchell
,
Ningqiang Gong
Keywords(s):
Bioengineering
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Oncology
,
Platform Technology
,
Protein/Peptide (Non-Antibody)
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Targeted, Enhanced Modification Of Lipid NanoparticlesTto Improve Tumor Therapeutic Efficacy
A method to inhibit small extracellular vesicles (sEVs) released by tumor cells to enhance lipid nanoparticle (LNP) accumulation in tumors. Problem: Lipid nanoparticles (LNPs) have shown promise as drug delivery systems for various diseases with several clinically approved products. However, their ability to deliver genes specifically to tumor cells...
Published: 4/11/2025
|
Inventor(s):
Michael Mitchell
,
Ningqiang Gong
,
Wenqun Zhong
,
Wei Guo
Keywords(s):
Bioengineering
,
Drug Delivery
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Small molecules that target RNA structures within the CoV genome
Chemical structure of the three lead molecules derived from the focused library screen against OC43-infected Vero E6 cell screening (Zafferani et al 2021) Invention Summary: The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes...
Published: 4/9/2025
|
Inventor(s):
Amanda Hargrove
,
Blanton Tolbert
,
Gary Brewer
,
Neeraj Patwardhan
,
Mei-Ling Li
Keywords(s):
Antiviral
,
Respiratory Disease
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
Anti-sense Oligonucleotide Targets Insulin Receptor Isoform A
IR-A ASO targets the exon 10-12 junction in of IR-A mRNA. Invention Summary: Breast cancer is one of the most common cancers among women, and while effective treatment options exist, there remains a critical need to enhance their efficacy and reduce their off-target effects to minimize toxicity. Expression of Insulin receptor-A (IR-A),...
Published: 4/8/2025
|
Inventor(s):
Teresa Wood
,
Christopher Galifi
Keywords(s):
Category(s):
Technology Classifications > Cancer
,
Technology Classifications > Therapeutics
Tricyclic Inhibitors of Ribosome‐Inhibiting Proteins
An image that shows p-stalk binding blockage would lead to the prevention of damage caused by Shiga or Ricin toxins Invention Summary: Shiga Toxin-producing E. coli (STEC) are very common bacteria that can cause infections that lead to approximately 100,000 illnesses, 3,000 hospitalizations, and about 90 deaths annually in the United States....
Published: 3/31/2025
|
Inventor(s):
Jacques Roberge
,
Xiao-Ping Li
,
Anastasiia Tsymbal
,
Nilgun Tumer
Keywords(s):
Category(s):
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
Intranasally-Delivered Therapy For The Treatment Of Depression And Dementia
Intranasal nasal dantrolene nanoparticles alone, or in combination with lithium, can provide protection against depression and dementia with minimal or no side effects. Problem: Major depression disorder (MDD) affects 350 million patients in the world and about 16% of the population in USA. In addition, up to 50% of Alzheimer’s disease (AD)...
Published: 3/12/2025
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Inventor(s):
Huafeng Wei
Keywords(s):
Aging
,
Immunology
,
Immunoncology
,
Infectious Disease
,
Inflammation
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics
Intranasal Dantrolene Nanoparticle Use For Treatment Of Alzheimer's Disease
Intranasal delivering of dantrolene nanoparticles could potentially be used to inhibit memory loss and reduce amyloid plaques in patients with Alzheimer's disease. Problem: Alzheimer’s disease (AD) is a devastating neurodegenerative disease. The deficit in the development of new drugs targeting the amyloid pathology over the past several...
Published: 3/12/2025
|
Inventor(s):
Huafeng Wei
,
Qing Cheng Meng
,
Ge Liang
,
Maryellen Eckenhoff
Keywords(s):
Aging
,
COVID-19
,
Nanotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Animal Health
,
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Food Science and Nutrition
,
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Therapeutics
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