Search Results - technology+classifications+%3e+therapeutics

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Iron Oxide Nanoparticles for Biofilm Control and Prevention of Tooth Decay
Iron oxide nanoparticle compositions disrupt biofilms, such as dental biofilms, and support oral disease prevention by combining catalytic nanoparticles with hydrogen peroxide. Problem : Oral diseases affect ~ 3.5 billion people globally, with untreated dental caries (tooth decay) remaining the most common condition in 2019 (World Health Organization...
Published: 7/29/2026   |   Updated: 7/29/2026   |   Inventor(s): Hyun (Michel) Koo, Lizeng Gao, David Cormode, Pratap Naha
Keywords(s): Dentistry, Nanotechnology
Category(s): Technology Classifications > Materials, Technology Classifications > Therapeutics
Engineered Protein with Enhance Antibody Targeting and Cytotoxic Response Properties
Problem: Antibody-based therapies have demonstrated promising results. Following binding of the mAb to its tumor target, interactions of the Fc-portion with Fc-receptors (Fc-R) expressed by effector cells (e.g. natural killer (NK) cells, macrophages and T-cells) may result in complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity...
Published: 7/16/2026   |   Updated: 7/16/2026   |   Inventor(s): Mark Greene, Hongtao Zhang, Xiaomin Song, Zhaocai Zhou, Ramachandran Murali, Masahide Tone, Zhiqiang Zhu, Lian Lam, Zheng Cai
Keywords(s): Bioengineering
Category(s): Technology Classifications > Therapeutics
Diagnostics And Therapeutics For Upper Airway And Sinus Infections
Problem: Severe cases of chronic rhinosinusitis often require surgery to open the sinuses and allow more effective draining and subsequent irrigation to prevent recurrent infection. In some of these surgical cases; however, the initial surgery is ineffective and the patient may need to undergo subsequent more aggressive surgeries to more fully open...
Published: 7/16/2026   |   Updated: 7/16/2026   |   Inventor(s): Noam Cohen, Robert Lee, Danielle Reed, Susan Weiss, Joel Maslow, Christine Roberts, Sara Cherry, Michael Kohanski, Nithin Adappa, James Palmer, Li Hui Tan
Keywords(s):  
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Therapeutics
Novel Compounds for Treatment for Friedreich Ataxia
New compounds identified through high throughput screening which improve mitochondrial function of Friedreich ataxia cells. Technology Overview: Friedreich ataxia (FA) is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, skeletal deformities, and hypertrophic cardiomyopathy....
Published: 7/15/2026   |   Updated: 7/15/2026   |   Inventor(s): Robert Wilson
Keywords(s): Neurodegenerative Diseases, Orphan Disease
Category(s): Technology Classifications > Therapeutics
Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis
Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL). Problem: ALS a neurodegenerative disease with poor prognosis. ALS is categorized into the familial and sporadic types, with the former accounting...
Published: 7/15/2026   |   Updated: 7/15/2026   |   Inventor(s): Huafeng Wei
Keywords(s): Genetic Disorders, Inflammation, Neurodegenerative Diseases, Neurology, Pulmonary, Small Molecule
Category(s): Technology Classifications > Therapeutics
Targeting CA19-9 with High-Specificity CAR-T Cells for Pancreatic Cancer
Chimeric antigen receptor (CAR) T cell therapy targeting CA19-9, an antigen over-expressed in several cancers, including 80-90% of pancreatic cancers. Problem: Pancreatic cancer is one of the deadliest common cancers and is now the sixth leading cause of cancer deaths worldwide, underscoring the need for better treatment options. One promising option...
Published: 7/8/2026   |   Updated: 7/8/2026   |   Inventor(s): Ben Stanger, Feiyan Mo
Keywords(s): Cell Therapy, Immunoncology, Immunotherapy, Oncology
Category(s): Technology Classifications > Therapeutics
Highly Selective, Bioengineered Cytokine Reduces Inflammation For Prevention Of Heart Failure After Heart Attack
Targeted delivery of an anti-inflammatory cytokine to prevent heart failure after myocardial infarction. Problem: Heart failure (HF) is one of the leading causes of death worldwide and is expected to affect more than eight million people in the US by 2030. Myocardial infarctions (MIs) are the leading cause of HF due to excessive inflammation caused...
Published: 7/1/2026   |   Updated: 7/1/2026   |   Inventor(s): Noor Momin, Emily Jacobs
Keywords(s): Bioengineering, Cardiovascular, Drug Delivery, Drug Target, Immunology, Immunotherapy, Inflammation, Protein/Peptide (Non-Antibody), Pulmonary
Category(s): Technology Classifications > Therapeutics
Safe and Highly Selective HDAC8 Inhibitors for Kidney Disease and Precision Therapies
HDAC8-targeting small molecules for kidney disease treatment with improved safety, selectivity, and therapeutic potential. Problem: Acute kidney injury (AKI) and focal segmental glomerulosclerosis (FSGS) affect millions of patients worldwide and can contribute to chronic kidney disease and end-stage renal failure, which only has a 5-year survival rate...
Published: 7/1/2026   |   Updated: 6/30/2026   |   Inventor(s): Donna Huryn, Neil Hukriede, Caroline Consoli
Keywords(s): Drug Target, Nephrology and Urology, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Improved CD-4 Mimetic Compounds HIV Treatment
Indoline core CD-4 mimetics are a HIV treatment that trick the virus into entering a vulnerable “open” conformation, allowing antibody-dependent cellular toxicity. Problem: HIV impacts 38 million individuals worldwide, many of whom are receiving treatment. A barrier to successful treatment is viral rebound after cessation of antiviral therapy....
Published: 6/25/2026   |   Updated: 6/25/2026   |   Inventor(s): Amos Smith, Christopher Fritschi, Joseph Sodroski
Keywords(s): HIV/AIDS, Infectious Disease, Small Molecule
Category(s): Technology Classifications > Therapeutics
Small-Molecule Therapeutic for Stabilizing HIV-1 Envelope Proteins to Increase Immune Response
Small-molecule inhibitor that prolongs exposure of HIV-1 to broadly neutralizing antibodies to suppress viral entry and infection Problem: The human immunodeficiency virus (HIV-1) infects human cells through binding of its envelope proteins to surface-expressed CD4 and CCR5 receptors. Broadly neutralizing antibodies can recognize the native, functional...
Published: 6/25/2026   |   Updated: 6/25/2026   |   Inventor(s): Amos Smith, Althea Lang, Joseph Sodroski
Keywords(s): Drug Target, HIV/AIDS, Immunology, Infectious Disease
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis
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